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Abnormal blood zinc concentration

MedGen UID:
892383
•Concept ID:
C4024711
•
Finding
Synonym: Abnormality of zinc homeostasis
 
HPO: HP:0008277

Definition

An abnormality of zinc ion homeostasis. [from HPO]

Professional guidelines

PubMed

Effect of hereditary haemochromatosis genotypes and iron overload on other trace elements.
Beckett JM, Ball MJ
Eur J Nutr 2013 Feb;52(1):255-61. Epub 2012 Feb 9 doi: 10.1007/s00394-012-0319-3. PMID: 22318759
Selective improvement of thymus and some T cell dysfunctions in NZB mice by in utero thymulin treatment.
Quéré P, Dardenne M, Bach MA
J Immunol 1985 Aug;135(2):1180-5. PMID: 2409141

Recent clinical studies

Etiology

Zinc in schizophrenia: A meta-analysis.
Joe P, Petrilli M, Malaspina D, Weissman J
Gen Hosp Psychiatry 2018 Jul-Aug;53:19-24. Epub 2018 Apr 27 doi: 10.1016/j.genhosppsych.2018.04.004. PMID: 29727763
Down syndrome--genetic and nutritional aspects of accompanying disorders.
Mazurek D, Wyka J
Rocz Panstw Zakl Hig 2015;66(3):189-94. PMID: 26400113
Blood metals concentration in type 1 and type 2 diabetics.
Forte G, Bocca B, Peruzzu A, Tolu F, Asara Y, Farace C, Oggiano R, Madeddu R
Biol Trace Elem Res 2013 Dec;156(1-3):79-90. Epub 2013 Nov 14 doi: 10.1007/s12011-013-9858-6. PMID: 24222606
Reference values for serum zinc concentration and prevalence of zinc deficiency in adult Iranian subjects.
Ghasemi A, Zahediasl S, Hosseini-Esfahani F, Azizi F
Biol Trace Elem Res 2012 Dec;149(3):307-14. Epub 2012 May 17 doi: 10.1007/s12011-012-9445-2. PMID: 22592845
Influence of copper on early development: prenatal and postnatal considerations.
Uriu-Adams JY, Scherr RE, Lanoue L, Keen CL
Biofactors 2010 Mar-Apr;36(2):136-52. doi: 10.1002/biof.85. PMID: 20232410

Diagnosis

Serum concentrations of heavy metals in women with endometrial polyps.
Yılmaz BK, Evliyaoğlu Ö, Yorgancı A, Özyer Ş, Üstün YE
J Obstet Gynaecol 2020 May;40(4):541-545. Epub 2019 Sep 3 doi: 10.1080/01443615.2019.1634022. PMID: 31478412
Zinc in schizophrenia: A meta-analysis.
Joe P, Petrilli M, Malaspina D, Weissman J
Gen Hosp Psychiatry 2018 Jul-Aug;53:19-24. Epub 2018 Apr 27 doi: 10.1016/j.genhosppsych.2018.04.004. PMID: 29727763
Down syndrome--genetic and nutritional aspects of accompanying disorders.
Mazurek D, Wyka J
Rocz Panstw Zakl Hig 2015;66(3):189-94. PMID: 26400113
The vitamin A-zinc connection: a review.
Smith JC Jr
Ann N Y Acad Sci 1980;355:62-75. doi: 10.1111/j.1749-6632.1980.tb21328.x. PMID: 6786155
Magnesium and zinc in seminal fluid of healthy males and patients with non-acute prostatitis with and without gonorrhoea.
Colleen S, Mårdh PA, Schytz A
Scand J Urol Nephrol 1975;9(3):192-7. doi: 10.3109/00365597509134210. PMID: 1209175

Therapy

Zinc in schizophrenia: A meta-analysis.
Joe P, Petrilli M, Malaspina D, Weissman J
Gen Hosp Psychiatry 2018 Jul-Aug;53:19-24. Epub 2018 Apr 27 doi: 10.1016/j.genhosppsych.2018.04.004. PMID: 29727763
The micronutrient supplements, zinc sulphate and folic acid, did not ameliorate sperm functional parameters in oligoasthenoteratozoospermic men.
Raigani M, Yaghmaei B, Amirjannti N, Lakpour N, Akhondi MM, Zeraati H, Hajihosseinal M, Sadeghi MR
Andrologia 2014;46(9):956-62. Epub 2013 Oct 23 doi: 10.1111/and.12180. PMID: 24147895
Blood metals concentration in type 1 and type 2 diabetics.
Forte G, Bocca B, Peruzzu A, Tolu F, Asara Y, Farace C, Oggiano R, Madeddu R
Biol Trace Elem Res 2013 Dec;156(1-3):79-90. Epub 2013 Nov 14 doi: 10.1007/s12011-013-9858-6. PMID: 24222606
Reference values for serum zinc concentration and prevalence of zinc deficiency in adult Iranian subjects.
Ghasemi A, Zahediasl S, Hosseini-Esfahani F, Azizi F
Biol Trace Elem Res 2012 Dec;149(3):307-14. Epub 2012 May 17 doi: 10.1007/s12011-012-9445-2. PMID: 22592845
Lymphocyte and granulocyte function in zinc-treated and zinc-deficient hemodialysis patients.
Briggs WA, Pedersen MM, Mahajan SK, Sillix DH, Prasad AS, McDonald FD
Kidney Int 1982 Jun;21(6):827-32. doi: 10.1038/ki.1982.106. PMID: 7132052

Prognosis

Socio-demographic factors and health status of adults with disability in Enugu Metropolis, Nigeria.
Ani PN, Eze SN, Abugu PI
Malawi Med J 2021 Mar;33(1):37-47. doi: 10.4314/mmj.v33i1.6. PMID: 34422232Free PMC Article
Circulating Zinc and Copper Levels are Associated with Sperm Quality in Obese Men after Metabolic Surgery: A Pilot Study.
Calderón B, Gómez-Martín JM, Cuadrado-Ayuso M, Cobeta P, Vega-Piñero B, Mateo R, Galindo J, Botella-Carretero JI
Nutrients 2020 Oct 30;12(11) doi: 10.3390/nu12113354. PMID: 33143218Free PMC Article
Dietary intake and zinc status in amyotrophic lateral sclerosis patients.
Lopes da Silva HF, Brito ANA, Freitas EPS, Dourado MET Jr, Sena-Evangelista KCM, Leite Lais L
Nutr Hosp 2017 Oct 27;34(5):1361-1367. doi: 10.20960/nh.1004. PMID: 29280652
Development of a plasma zinc concentration cutoff to identify individuals with severe zinc deficiency based on results from adults undergoing experimental severe dietary zinc restriction and individuals with acrodermatitis enteropathica.
Wessells KR, King JC, Brown KH
J Nutr 2014 Aug;144(8):1204-10. Epub 2014 May 21 doi: 10.3945/jn.114.191585. PMID: 24850624
Serum zinc and copper concentrations in maternal and umbilical cord blood. Relation to course and outcome of pregnancy.
Bro S, Berendtsen H, Nørgaard J, Høst A, Jørgensen PJ
Scand J Clin Lab Invest 1988 Dec;48(8):805-11. doi: 10.3109/00365518809088764. PMID: 3238326

Clinical prediction guides

Serum concentrations of heavy metals in women with endometrial polyps.
Yılmaz BK, Evliyaoğlu Ö, Yorgancı A, Özyer Ş, Üstün YE
J Obstet Gynaecol 2020 May;40(4):541-545. Epub 2019 Sep 3 doi: 10.1080/01443615.2019.1634022. PMID: 31478412
Dietary habits; concentration of copper, zinc, and Cu-to-Zn ratio in serum and ability status of patients with relapsing-remitting multiple sclerosis.
Socha K, Karpińska E, Kochanowicz J, Soroczyńska J, Jakoniuk M, Wilkiel M, Mariak ZD, Borawska MH
Nutrition 2017 Jul-Aug;39-40:76-81. Epub 2017 Mar 23 doi: 10.1016/j.nut.2017.03.009. PMID: 28606574
Zinc: an important cofactor in haemostasis and thrombosis.
Vu TT, Fredenburgh JC, Weitz JI
Thromb Haemost 2013 Mar;109(3):421-30. Epub 2013 Jan 10 doi: 10.1160/TH12-07-0465. PMID: 23306381
Influence of copper on early development: prenatal and postnatal considerations.
Uriu-Adams JY, Scherr RE, Lanoue L, Keen CL
Biofactors 2010 Mar-Apr;36(2):136-52. doi: 10.1002/biof.85. PMID: 20232410
Analysis and evaluation of zinc and copper in human plasma and serum.
Smith JC, Holbrook JT, Danford DE
J Am Coll Nutr 1985;4(6):627-38. doi: 10.1080/07315724.1985.10720105. PMID: 4078201

Recent systematic reviews

Association between female circulating heavy metal concentration and abortion: a systematic review and meta-analysis.
Ren M, Wang L, Wen L, Chen J, Quan S, Shi X
Front Endocrinol (Lausanne) 2023;14:1216507. Epub 2023 Aug 29 doi: 10.3389/fendo.2023.1216507. PMID: 37711903Free PMC Article
Micronutrient status in children and adolescents with Down syndrome: systematic review and meta-analysis.
Barišić A, Ravančić ME, Majstorivić D, Vraneković J
J Intellect Disabil Res 2023 Aug;67(8):701-719. Epub 2023 May 22 doi: 10.1111/jir.13042. PMID: 37218392
Selenium and Other Trace Elements in the Etiology of Parkinson's Disease: A Systematic Review and Meta-Analysis of Case-Control Studies.
Adani G, Filippini T, Michalke B, Vinceti M
Neuroepidemiology 2020;54(1):1-23. Epub 2019 Aug 27 doi: 10.1159/000502357. PMID: 31454800

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