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Abnormal blood zinc concentration

MedGen UID:
892383
•Concept ID:
C4024711
•
Finding
Synonym: Abnormality of zinc homeostasis
 
HPO: HP:0008277

Definition

An abnormality of zinc ion homeostasis. [from HPO]

Professional guidelines

PubMed

Effect of hereditary haemochromatosis genotypes and iron overload on other trace elements.
Beckett JM, Ball MJ
Eur J Nutr 2013 Feb;52(1):255-61. Epub 2012 Feb 9 doi: 10.1007/s00394-012-0319-3. PMID: 22318759
Selective improvement of thymus and some T cell dysfunctions in NZB mice by in utero thymulin treatment.
Quéré P, Dardenne M, Bach MA
J Immunol 1985 Aug;135(2):1180-5. PMID: 2409141

Recent clinical studies

Etiology

Down syndrome--genetic and nutritional aspects of accompanying disorders.
Mazurek D, Wyka J
Rocz Panstw Zakl Hig 2015;66(3):189-94. PMID: 26400113
The serum zinc, copper, iron, and chromium concentrations in epileptic children.
Wojciak RW, Mojs E, Stanislawska-Kubiak M, Samborski W
Epilepsy Res 2013 Mar;104(1-2):40-4. Epub 2012 Oct 25 doi: 10.1016/j.eplepsyres.2012.09.009. PMID: 23103060
Are serum zinc and copper levels related to semen quality?
Yuyan L, Junqing W, Wei Y, Weijin Z, Ersheng G
Fertil Steril 2008 Apr;89(4):1008-11. Epub 2007 Aug 6 doi: 10.1016/j.fertnstert.2007.04.028. PMID: 17678909
Essential fatty acids in Alzheimer's disease.
Corrigan FM, Van Rhijn A, Horrobin DF
Ann N Y Acad Sci 1991;640:250-2. doi: 10.1111/j.1749-6632.1991.tb00228.x. PMID: 1776746
Diabetes: The quest for basal normoglycaemia.
Holman RR, Turner RC
Lancet 1977 Feb 26;1(8009):469-74. doi: 10.1016/s0140-6736(77)91954-7. PMID: 65573

Diagnosis

A "signal-off" anodic photoelectrochemical sensor based on ZnIn(2)S(4)/TiO(2) heterojunction for dopamine detection.
Shen M, Hu X
Talanta 2025 Jan 1;281:126800. Epub 2024 Sep 1 doi: 10.1016/j.talanta.2024.126800. PMID: 39241644
CeO(2)·ZnO@biomass-derived carbon nanocomposite-based electrochemical sensor for efficient detection of ascorbic acid.
Ahmed J, Faisal M, Algethami JS, Alsaiari M, Jalalah M, Harraz FA
Anal Biochem 2024 Sep;692:115574. Epub 2024 May 22 doi: 10.1016/j.ab.2024.115574. PMID: 38782251
Down syndrome--genetic and nutritional aspects of accompanying disorders.
Mazurek D, Wyka J
Rocz Panstw Zakl Hig 2015;66(3):189-94. PMID: 26400113
The serum zinc, copper, iron, and chromium concentrations in epileptic children.
Wojciak RW, Mojs E, Stanislawska-Kubiak M, Samborski W
Epilepsy Res 2013 Mar;104(1-2):40-4. Epub 2012 Oct 25 doi: 10.1016/j.eplepsyres.2012.09.009. PMID: 23103060
Effects of ion composition and tonicity on human neutrophil antibacterial activity.
Verghese MW, Boucher RC
Am J Respir Cell Mol Biol 1998 Dec;19(6):920-8. doi: 10.1165/ajrcmb.19.6.3290. PMID: 9843926

Therapy

Effects of ion composition and tonicity on human neutrophil antibacterial activity.
Verghese MW, Boucher RC
Am J Respir Cell Mol Biol 1998 Dec;19(6):920-8. doi: 10.1165/ajrcmb.19.6.3290. PMID: 9843926
Zinc abuse and sideroblastic anemia.
Ramadurai J, Shapiro C, Kozloff M, Telfer M
Am J Hematol 1993 Feb;42(2):227-8. doi: 10.1002/ajh.2830420217. PMID: 8438885
Essential fatty acids in Alzheimer's disease.
Corrigan FM, Van Rhijn A, Horrobin DF
Ann N Y Acad Sci 1991;640:250-2. doi: 10.1111/j.1749-6632.1991.tb00228.x. PMID: 1776746
Zinc-dependent chemotactic defect in an infant with acrodermatitis.
Businco L, Menghi AM, Rossi P, D'Amelio R, Galli E
Arch Dis Child 1980 Dec;55(12):966-8. doi: 10.1136/adc.55.12.966. PMID: 7458399Free PMC Article
Diabetes: The quest for basal normoglycaemia.
Holman RR, Turner RC
Lancet 1977 Feb 26;1(8009):469-74. doi: 10.1016/s0140-6736(77)91954-7. PMID: 65573

Prognosis

CaEDTA vs CaEDTA plus BAL to treat children with elevated blood lead levels.
O'Connor ME
Clin Pediatr (Phila) 1992 Jul;31(7):386-90. doi: 10.1177/000992289203100701. PMID: 1617861
Red cell caesium, lithium and selenium in abstinent alcoholics.
Corrigan FM, Besson JA, Ward NI
Alcohol Alcohol 1991;26(3):309-14. doi: 10.1093/oxfordjournals.alcalc.a045116. PMID: 1930363
Acrodermatitis enteropathica without hypozincemia: therapeutic effect of a pancreatic enzyme preparation due to a zinc-binding ligand.
Krieger I, Evans GW
J Pediatr 1980 Jan;96(1):32-5. doi: 10.1016/s0022-3476(80)80319-2. PMID: 7350312
Trace elements and acute phase reactants in gold treated rheumatoid arthritis patients.
Menard HA, Barrette M, Lamoureux G, Lecomte R, Paradis P, Monaro S, Drapeau G
J Rheumatol Suppl 1979;5:143-8. PMID: 114644
Diabetes: The quest for basal normoglycaemia.
Holman RR, Turner RC
Lancet 1977 Feb 26;1(8009):469-74. doi: 10.1016/s0140-6736(77)91954-7. PMID: 65573

Clinical prediction guides

Thyroid hypofunction in Down's syndrome: is it related to oxidative stress?
Kanavin OJ, Aaseth J, Birketvedt GS
Biol Trace Elem Res 2000 Winter;78(1-3):35-42. doi: 10.1385/BTER:78:1-3:35. PMID: 11314986
PLZF-RAR alpha fusion proteins generated from the variant t(11;17)(q23;q21) translocation in acute promyelocytic leukemia inhibit ligand-dependent transactivation of wild-type retinoic acid receptors.
Chen Z, Guidez F, Rousselot P, Agadir A, Chen SJ, Wang ZY, Degos L, Zelent A, Waxman S, Chomienne C
Proc Natl Acad Sci U S A 1994 Feb 1;91(3):1178-82. doi: 10.1073/pnas.91.3.1178. PMID: 8302850Free PMC Article
Influence of nicotine on tissue trace element concentrations and tissue antioxidant defense.
Dubick MA, Keen CL
Biol Trace Elem Res 1991 Nov;31(2):97-109. doi: 10.1007/BF02990418. PMID: 9438031
Toxicity of human hemoglobin solution infused into rabbits.
White CT, Murray AJ, Greene JR, Smith DJ, Medina F, Makovec GT, Martin EJ, Bolin RB
J Lab Clin Med 1986 Aug;108(2):121-31. PMID: 3734586
Thymic hormone deficiency in normal ageing and Down's syndrome: is there a primary failure of the thymus?
Fabris N, Mocchegiani E, Amadio L, Zannotti M, Licastro F, Franceschi C
Lancet 1984 May 5;1(8384):983-6. doi: 10.1016/s0140-6736(84)92325-0. PMID: 6143966

Recent systematic reviews

Antioxidant supplementation for sickle cell disease.
Bolarinwa AB, Oduwole O, Okebe J, Ogbenna AA, Otokiti OE, Olatinwo AT
Cochrane Database Syst Rev 2024 May 22;5(5):CD013590. doi: 10.1002/14651858.CD013590.pub2. PMID: 38775255Free PMC Article
Association between female circulating heavy metal concentration and abortion: a systematic review and meta-analysis.
Ren M, Wang L, Wen L, Chen J, Quan S, Shi X
Front Endocrinol (Lausanne) 2023;14:1216507. Epub 2023 Aug 29 doi: 10.3389/fendo.2023.1216507. PMID: 37711903Free PMC Article
Micronutrient status in children and adolescents with Down syndrome: systematic review and meta-analysis.
Barišić A, Ravančić ME, Majstorivić D, Vraneković J
J Intellect Disabil Res 2023 Aug;67(8):701-719. Epub 2023 May 22 doi: 10.1111/jir.13042. PMID: 37218392
Selenium and Other Trace Elements in the Etiology of Parkinson's Disease: A Systematic Review and Meta-Analysis of Case-Control Studies.
Adani G, Filippini T, Michalke B, Vinceti M
Neuroepidemiology 2020;54(1):1-23. Epub 2019 Aug 27 doi: 10.1159/000502357. PMID: 31454800

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