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Increased serum zinc

MedGen UID:
892436
Concept ID:
C0856208
Finding
Synonym: Hyperzincemia
 
HPO: HP:0011424

Definition

An increased concentration of zinc in the blood. [from HPO]

Conditions with this feature

Hyperzincemia with functional zinc depletion
MedGen UID:
356415
Concept ID:
C1865986
Disease or Syndrome
Autoinflammatory syndrome with cytopenia, hyperzincemia, and hypercalprotectinemia (AICZC) is characterized by chronic systemic inflammation, prominent skin inflammation, arthralgias/arthritis, hepatosplenomegaly, pancytopenia, and failure to thrive. A hallmark of the disease is the extreme increase in serum concentrations of zinc and the proinflammatory alarmins MRP8 (S100A8; 123885) and MRP14 (S100A9; 123886), which make up the heterodimeric calcium- and zinc-binding protein complex calprotectin. Severe anemia and neutropenia are accompanied by thrombocytopenia in most patients, and bone marrow aspirates show dysgranulopoiesis and dyserythropoiesis. Intrafamilial variable expressivity and incomplete penetrance have been observed (summary by Holzinger et al., 2015).

Professional guidelines

PubMed

Cantoral A, Téllez-Rojo M, Shamah-Levy T, Schnaas L, Hernández-Ávila M, Peterson KE, Ettinger AS
Food Nutr Bull 2015 Jun;36(2):111-9. doi: 10.1177/0379572115586400. PMID: 26121697Free PMC Article

Recent clinical studies

Etiology

Seiki Y, Ikezawa K, Watsuji K, Urabe M, Kai Y, Takada R, Yamai T, Mukai K, Nakabori T, Uehara H, Ishibashi M, Ohkawa K
Int J Clin Oncol 2024 Aug;29(8):1173-1181. Epub 2024 May 10 doi: 10.1007/s10147-024-02544-w. PMID: 38724773
Ruangritchankul S, Sumananusorn C, Sirivarasai J, Monsuwan W, Sritara P
Nutrients 2023 Jan 9;15(2) doi: 10.3390/nu15020322. PMID: 36678192Free PMC Article
Lee YH, Bang ES, Lee JH, Lee JD, Kang DR, Hong J, Lee JM
Biol Trace Elem Res 2019 Apr;188(2):316-325. Epub 2018 Jul 25 doi: 10.1007/s12011-018-1429-4. PMID: 30047077Free PMC Article
Cho JM, Kim JY, Yang HR
Pediatr Neonatol 2019 Apr;60(2):201-209. Epub 2018 Jun 25 doi: 10.1016/j.pedneo.2018.06.006. PMID: 30031808
Kim J, Ahn J
Biol Trace Elem Res 2014 Feb;157(2):101-6. Epub 2014 Jan 10 doi: 10.1007/s12011-013-9885-3. PMID: 24402636

Diagnosis

Foroozanfard F, Jamilian M, Jafari Z, Khassaf A, Hosseini A, Khorammian H, Asemi Z
Exp Clin Endocrinol Diabetes 2015 Apr;123(4):215-20. Epub 2015 Apr 13 doi: 10.1055/s-0035-1548790. PMID: 25868059
Kim J, Ahn J
Biol Trace Elem Res 2014 Feb;157(2):101-6. Epub 2014 Jan 10 doi: 10.1007/s12011-013-9885-3. PMID: 24402636
Sugiura T, Goto K, Ito K, Ban K, Okada S, Moriyama A, Togari H
Acta Paediatr 2006 Jul;95(7):857-60. doi: 10.1080/08035250500482255. PMID: 16801185

Therapy

Seiki Y, Ikezawa K, Watsuji K, Urabe M, Kai Y, Takada R, Yamai T, Mukai K, Nakabori T, Uehara H, Ishibashi M, Ohkawa K
Int J Clin Oncol 2024 Aug;29(8):1173-1181. Epub 2024 May 10 doi: 10.1007/s10147-024-02544-w. PMID: 38724773
Cho JM, Kim JY, Yang HR
Pediatr Neonatol 2019 Apr;60(2):201-209. Epub 2018 Jun 25 doi: 10.1016/j.pedneo.2018.06.006. PMID: 30031808
Kim J, Ahn J
Biol Trace Elem Res 2014 Feb;157(2):101-6. Epub 2014 Jan 10 doi: 10.1007/s12011-013-9885-3. PMID: 24402636
Koehler K, Parr MK, Geyer H, Mester J, Schänzer W
Eur J Clin Nutr 2009 Jan;63(1):65-70. Epub 2007 Sep 19 doi: 10.1038/sj.ejcn.1602899. PMID: 17882141
Schölmerich J, Freudemann A, Köttgen E, Wietholtz H, Steiert B, Löhle E, Häussinger D, Gerok W
Am J Clin Nutr 1987 Jun;45(6):1480-6. doi: 10.1093/ajcn/45.6.1480. PMID: 3591728

Clinical prediction guides

Kim M, Maruhashi T, Asari Y
Nutrients 2024 Aug 25;16(17) doi: 10.3390/nu16172841. PMID: 39275159Free PMC Article
Ruangritchankul S, Sumananusorn C, Sirivarasai J, Monsuwan W, Sritara P
Nutrients 2023 Jan 9;15(2) doi: 10.3390/nu15020322. PMID: 36678192Free PMC Article
Lee YH, Bang ES, Lee JH, Lee JD, Kang DR, Hong J, Lee JM
Biol Trace Elem Res 2019 Apr;188(2):316-325. Epub 2018 Jul 25 doi: 10.1007/s12011-018-1429-4. PMID: 30047077Free PMC Article
Cho JM, Kim JY, Yang HR
Pediatr Neonatol 2019 Apr;60(2):201-209. Epub 2018 Jun 25 doi: 10.1016/j.pedneo.2018.06.006. PMID: 30031808
Koehler K, Parr MK, Geyer H, Mester J, Schänzer W
Eur J Clin Nutr 2009 Jan;63(1):65-70. Epub 2007 Sep 19 doi: 10.1038/sj.ejcn.1602899. PMID: 17882141

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