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Decreased level of platelet-activating factor

MedGen UID:
893026
•Concept ID:
C4073144
•
Finding
Synonym: Decreased level of PAF
 
HPO: HP:0040179

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased level of platelet-activating factor

Professional guidelines

PubMed

Evidence-based treatment of acute pancreatitis: a look at established paradigms.
Heinrich S, Schäfer M, Rousson V, Clavien PA
Ann Surg 2006 Feb;243(2):154-68. doi: 10.1097/01.sla.0000197334.58374.70. PMID: 16432347Free PMC Article
Review of oxidative stress in brain and spinal cord injury: suggestions for pharmacological and nutritional management strategies.
Juurlink BH, Paterson PG
J Spinal Cord Med 1998 Oct;21(4):309-34. doi: 10.1080/10790268.1998.11719540. PMID: 10096045
Pharmacologic treatment of venous leg ulcers.
Dormandy JA
J Cardiovasc Pharmacol 1995;25 Suppl 2:S61-5. doi: 10.1097/00005344-199500252-00013. PMID: 8699864

Recent clinical studies

Etiology

Dysregulation of Biomarkers of Hemostatic Activation and Inflammatory Processes are Associated with Adverse Outcomes in Pulmonary Embolism.
Darwish I, Fareed J, Brailovsky Y, Hoppensteadt D, Slajus B, Bontekoe E, De Stefano F, Reed T, Darki A
Clin Appl Thromb Hemost 2022 Jan-Dec;28:10760296211064898. doi: 10.1177/10760296211064898. PMID: 35043658Free PMC Article
Evaluation of maternal plasma platelet activating factor acetylhydrolase activity and mRNA expression in pre-eclampsia: a case control study.
Gupta P, Agarwal R, Bhaskaran S, Garg S, Mehndiratta M, Radhakrishnan G, Singh A, Agarwal R, Narang D
J Obstet Gynaecol 2021 Jul;41(5):726-732. Epub 2020 Oct 19 doi: 10.1080/01443615.2020.1789956. PMID: 33073639
Correlation of platelet activating factor and age-related macular degeneration.
Nitoda E, Koutsilieris M, Brouzas D, Koutsandrea C, Philippou A, Ladas D, Moschos MM
Expert Opin Ther Targets 2014 Sep;18(9):987-97. Epub 2014 Jul 31 doi: 10.1517/14728222.2014.930439. PMID: 25077601
Diet and hemostatic factors.
Tracy RP
Curr Atheroscler Rep 1999 Nov;1(3):243-8. doi: 10.1007/s11883-999-0039-1. PMID: 11122717
Juvenile rheumatoid arthritis.
Gallagher KT, Bernstein B
Curr Opin Rheumatol 1999 Sep;11(5):372-6. doi: 10.1097/00002281-199909000-00008. PMID: 10503657

Diagnosis

Platelet-activating factor acetylhydrolase is a biomarker of severe anaphylaxis in children.
Upton JEM, Hoang JA, Leon-Ponte M, Finkelstein Y, Du YJ, Adeli K, Eiwegger T, Grunebaum E, Vadas P
Allergy 2022 Sep;77(9):2665-2676. Epub 2022 Apr 13 doi: 10.1111/all.15308. PMID: 35396721
Laboratory diagnosis of heparin-induced thrombocytopenia.
Warkentin TE
Int J Lab Hematol 2019 May;41 Suppl 1:15-25. doi: 10.1111/ijlh.12993. PMID: 31069988
Apolipoprotein M.
Ren K, Tang ZL, Jiang Y, Tan YM, Yi GH
Clin Chim Acta 2015 Jun 15;446:21-9. Epub 2015 Apr 7 doi: 10.1016/j.cca.2015.03.038. PMID: 25858547
Flaxseed and cardiovascular health.
Prasad K
J Cardiovasc Pharmacol 2009 Nov;54(5):369-77. doi: 10.1097/FJC.0b013e3181af04e5. PMID: 19568181
Juvenile rheumatoid arthritis.
Gallagher KT, Bernstein B
Curr Opin Rheumatol 1999 Sep;11(5):372-6. doi: 10.1097/00002281-199909000-00008. PMID: 10503657

Therapy

Laboratory diagnosis of heparin-induced thrombocytopenia.
Warkentin TE
Int J Lab Hematol 2019 May;41 Suppl 1:15-25. doi: 10.1111/ijlh.12993. PMID: 31069988
Correlation of platelet activating factor and age-related macular degeneration.
Nitoda E, Koutsilieris M, Brouzas D, Koutsandrea C, Philippou A, Ladas D, Moschos MM
Expert Opin Ther Targets 2014 Sep;18(9):987-97. Epub 2014 Jul 31 doi: 10.1517/14728222.2014.930439. PMID: 25077601
Flaxseed and cardiovascular health.
Prasad K
J Cardiovasc Pharmacol 2009 Nov;54(5):369-77. doi: 10.1097/FJC.0b013e3181af04e5. PMID: 19568181
Statins and thrombin.
Fenton JW 2nd, Brezniak DV, Ofosu FA, Shen GX, Jacobson JR, Garcia JG
Curr Drug Targets Cardiovasc Haematol Disord 2005 Apr;5(2):115-20. doi: 10.2174/1568006043586189. PMID: 15853752
Juvenile rheumatoid arthritis.
Gallagher KT, Bernstein B
Curr Opin Rheumatol 1999 Sep;11(5):372-6. doi: 10.1097/00002281-199909000-00008. PMID: 10503657

Prognosis

HOMER3 promotes non-small cell lung cancer growth and metastasis primarily through GABPB1-mediated mitochondrial metabolism.
Sun T, Song C, Zhao G, Feng S, Wei J, Zhang L, Liu X, Li Z, Zhang H
Cell Death Dis 2023 Dec 11;14(12):814. doi: 10.1038/s41419-023-06335-5. PMID: 38081871Free PMC Article
PAFAH1B3 predicts poor prognosis and promotes progression in lung adenocarcinoma.
Tang S, Ni J, Chen B, Sun F, Huang J, Ni S, Tang Z
BMC Cancer 2022 May 9;22(1):525. doi: 10.1186/s12885-022-09617-x. PMID: 35534807Free PMC Article
Platelet-activating factor acetylhydrolase is a biomarker of severe anaphylaxis in children.
Upton JEM, Hoang JA, Leon-Ponte M, Finkelstein Y, Du YJ, Adeli K, Eiwegger T, Grunebaum E, Vadas P
Allergy 2022 Sep;77(9):2665-2676. Epub 2022 Apr 13 doi: 10.1111/all.15308. PMID: 35396721
Dysregulation of Biomarkers of Hemostatic Activation and Inflammatory Processes are Associated with Adverse Outcomes in Pulmonary Embolism.
Darwish I, Fareed J, Brailovsky Y, Hoppensteadt D, Slajus B, Bontekoe E, De Stefano F, Reed T, Darki A
Clin Appl Thromb Hemost 2022 Jan-Dec;28:10760296211064898. doi: 10.1177/10760296211064898. PMID: 35043658Free PMC Article
Statins and thrombin.
Fenton JW 2nd, Brezniak DV, Ofosu FA, Shen GX, Jacobson JR, Garcia JG
Curr Drug Targets Cardiovasc Haematol Disord 2005 Apr;5(2):115-20. doi: 10.2174/1568006043586189. PMID: 15853752

Clinical prediction guides

Anti-heat shock protein 10 IgG in chronic spontaneous urticaria: Relation with miRNA-101-5p and platelet-activating factor.
Choi BY, Yang EM, Jung HW, Shin MK, Jo J, Cha HY, Park HS, Kang HC, Ye YM
Allergy 2023 Dec;78(12):3166-3177. Epub 2023 Jul 7 doi: 10.1111/all.15810. PMID: 37415527
Platelet-activating factor acetylhydrolase is a biomarker of severe anaphylaxis in children.
Upton JEM, Hoang JA, Leon-Ponte M, Finkelstein Y, Du YJ, Adeli K, Eiwegger T, Grunebaum E, Vadas P
Allergy 2022 Sep;77(9):2665-2676. Epub 2022 Apr 13 doi: 10.1111/all.15308. PMID: 35396721
Microglial Store-operated Calcium Signaling in Health and in Alzheimer's Disease.
McLarnon JG
Curr Alzheimer Res 2020;17(12):1057-1064. doi: 10.2174/1567205018666210119143817. PMID: 33463465
Postprandial effects of wine consumption on Platelet Activating Factor metabolic enzymes.
Argyrou C, Vlachogianni I, Stamatakis G, Demopoulos CA, Antonopoulou S, Fragopoulou E
Prostaglandins Other Lipid Mediat 2017 May;130:23-29. Epub 2017 Mar 16 doi: 10.1016/j.prostaglandins.2017.03.002. PMID: 28323197
Statins and thrombin.
Fenton JW 2nd, Brezniak DV, Ofosu FA, Shen GX, Jacobson JR, Garcia JG
Curr Drug Targets Cardiovasc Haematol Disord 2005 Apr;5(2):115-20. doi: 10.2174/1568006043586189. PMID: 15853752

Recent systematic reviews

Lung fluid biomarkers for acute respiratory distress syndrome: a systematic review and meta-analysis.
Wang Y, Wang H, Zhang C, Zhang C, Yang H, Gao R, Tong Z
Crit Care 2019 Feb 12;23(1):43. doi: 10.1186/s13054-019-2336-6. PMID: 30755248Free PMC Article

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