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Abnormal circulating phospholipid concentration

MedGen UID:
892849
•Concept ID:
C4073141
•
Finding
Synonym: Abnormal level of phospholipids
 
HPO: HP:0040176

Definition

Any deviation from the normal concentration of a phospholipid in the blood circulation. [from HPO]

Professional guidelines

PubMed

Treprostinil treatment decreases circulating platelet microvesicles and their procoagulant activity in pediatric pulmonary hypertension.
Bacha NC, Levy M, Guerin CL, Le Bonniec B, Harroche A, Szezepanski I, Renard JM, Gaussem P, Israel-Biet D, Boulanger CM, Smadja DM
Pediatr Pulmonol 2019 Jan;54(1):66-72. Epub 2018 Nov 28 doi: 10.1002/ppul.24190. PMID: 30485728
Reconstituted HDL (Milano) Treatment Efficaciously Reverses Heart Failure with Preserved Ejection Fraction in Mice.
Mishra M, Muthuramu I, Aboumsallem JP, Kempen H, De Geest B
Int J Mol Sci 2018 Oct 30;19(11) doi: 10.3390/ijms19113399. PMID: 30380754Free PMC Article
Changes in the concentration and composition of lipids and lipoproteins in primary hyperlipoproteinemia during treatment with bezafibrate.
Hutt V, Wechsler JG, Klör HU, Ditschuneit H
Arzneimittelforschung 1983;33(8):1185-90. PMID: 6685498

Recent clinical studies

Etiology

Nuclear Magnetic Resonance-Based Metabolomics and Risk of CKD.
Geng TT, Chen JX, Lu Q, Wang PL, Xia PF, Zhu K, Li Y, Guo KQ, Yang K, Liao YF, Zhou YF, Liu G, Pan A
Am J Kidney Dis 2024 Jan;83(1):9-17. Epub 2023 Sep 9 doi: 10.1053/j.ajkd.2023.05.014. PMID: 37678743
Eryptosis in lead-exposed workers.
Aguilar-Dorado IC, Hernández G, Quintanar-Escorza MA, Maldonado-Vega M, Rosas-Flores M, Calderón-Salinas JV
Toxicol Appl Pharmacol 2014 Dec 1;281(2):195-202. Epub 2014 Oct 27 doi: 10.1016/j.taap.2014.10.003. PMID: 25448684
Circulating palmitoleic acid and risk of metabolic abnormalities and new-onset diabetes.
Mozaffarian D, Cao H, King IB, Lemaitre RN, Song X, Siscovick DS, Hotamisligil GS
Am J Clin Nutr 2010 Dec;92(6):1350-8. Epub 2010 Oct 13 doi: 10.3945/ajcn.110.003970. PMID: 20943795Free PMC Article
Elevated blood flow resistance in uterine arteries of women with unexplained recurrent pregnancy loss.
Habara T, Nakatsuka M, Konishi H, Asagiri K, Noguchi S, Kudo T
Hum Reprod 2002 Jan;17(1):190-4. doi: 10.1093/humrep/17.1.190. PMID: 11756386
Circulating plasma platelet activating factor in persistent pulmonary hypertension of the newborn.
Caplan MS, Hsueh W, Sun XM, Gidding SS, Hageman JR
Am Rev Respir Dis 1990 Dec;142(6 Pt 1):1258-62. doi: 10.1164/ajrccm/142.6_Pt_1.1258. PMID: 2252241

Diagnosis

Plasma phospholipid dysregulation in patients with cystathionine-β synthase deficiency.
Di Minno A, Anesi A, Chiesa M, Cirillo F, Colombo GI, Orsini RC, Capasso F, Morisco F, Fiorelli S, Eligini S, Cavalca V, Tremoli E, Porro B, Di Minno MND
Nutr Metab Cardiovasc Dis 2020 Nov 27;30(12):2286-2295. Epub 2020 Jul 23 doi: 10.1016/j.numecd.2020.07.019. PMID: 32912785
Eryptosis in lead-exposed workers.
Aguilar-Dorado IC, Hernández G, Quintanar-Escorza MA, Maldonado-Vega M, Rosas-Flores M, Calderón-Salinas JV
Toxicol Appl Pharmacol 2014 Dec 1;281(2):195-202. Epub 2014 Oct 27 doi: 10.1016/j.taap.2014.10.003. PMID: 25448684
Plasma sphingosine-1-phosphate is elevated in obesity.
Kowalski GM, Carey AL, Selathurai A, Kingwell BA, Bruce CR
PLoS One 2013;8(9):e72449. Epub 2013 Sep 6 doi: 10.1371/journal.pone.0072449. PMID: 24039766Free PMC Article
Antiphospholipid antibodies: discovery, definitions, detection and disease.
McIntyre JA, Wagenknecht DR, Faulk WP
Prog Lipid Res 2003 May;42(3):176-237. doi: 10.1016/s0163-7827(02)00048-6. PMID: 12689618
Circulating plasma platelet activating factor in persistent pulmonary hypertension of the newborn.
Caplan MS, Hsueh W, Sun XM, Gidding SS, Hageman JR
Am Rev Respir Dis 1990 Dec;142(6 Pt 1):1258-62. doi: 10.1164/ajrccm/142.6_Pt_1.1258. PMID: 2252241

Therapy

Reconstituted HDL (Milano) Treatment Efficaciously Reverses Heart Failure with Preserved Ejection Fraction in Mice.
Mishra M, Muthuramu I, Aboumsallem JP, Kempen H, De Geest B
Int J Mol Sci 2018 Oct 30;19(11) doi: 10.3390/ijms19113399. PMID: 30380754Free PMC Article
Eryptosis in lead-exposed workers.
Aguilar-Dorado IC, Hernández G, Quintanar-Escorza MA, Maldonado-Vega M, Rosas-Flores M, Calderón-Salinas JV
Toxicol Appl Pharmacol 2014 Dec 1;281(2):195-202. Epub 2014 Oct 27 doi: 10.1016/j.taap.2014.10.003. PMID: 25448684
Coformulated N-octanoyl-glucosylceramide improves cellular delivery and cytotoxicity of liposomal doxorubicin.
Veldman RJ, Koning GA, van Hell A, Zerp S, Vink SR, Storm G, Verheij M, van Blitterswijk WJ
J Pharmacol Exp Ther 2005 Nov;315(2):704-10. Epub 2005 Jul 22 doi: 10.1124/jpet.105.087486. PMID: 16040815
Circulating plasma platelet activating factor in persistent pulmonary hypertension of the newborn.
Caplan MS, Hsueh W, Sun XM, Gidding SS, Hageman JR
Am Rev Respir Dis 1990 Dec;142(6 Pt 1):1258-62. doi: 10.1164/ajrccm/142.6_Pt_1.1258. PMID: 2252241
Stability and clearance of small unilamellar liposomes. Studies with normal and lipoprotein-deficient mice.
Senior J, Gregoriadis G, Mitropoulos KA
Biochim Biophys Acta 1983 Oct 4;760(1):111-8. doi: 10.1016/0304-4165(83)90131-9. PMID: 6615877

Prognosis

Treprostinil treatment decreases circulating platelet microvesicles and their procoagulant activity in pediatric pulmonary hypertension.
Bacha NC, Levy M, Guerin CL, Le Bonniec B, Harroche A, Szezepanski I, Renard JM, Gaussem P, Israel-Biet D, Boulanger CM, Smadja DM
Pediatr Pulmonol 2019 Jan;54(1):66-72. Epub 2018 Nov 28 doi: 10.1002/ppul.24190. PMID: 30485728
In vivo ³¹P magnetic resonance spectroscopic imaging (MRSI) for metabolic profiling of human breast cancer xenografts.
Esmaeili M, Moestue SA, Hamans BC, Veltien A, Kristian A, Engebråten O, Maelandsmo GM, Gribbestad IS, Bathen TF, Heerschap A
J Magn Reson Imaging 2015 Mar;41(3):601-9. Epub 2014 Feb 14 doi: 10.1002/jmri.24588. PMID: 24532410
Distinct choline metabolic profiles are associated with differences in gene expression for basal-like and luminal-like breast cancer xenograft models.
Moestue SA, Borgan E, Huuse EM, Lindholm EM, Sitter B, Børresen-Dale AL, Engebraaten O, Maelandsmo GM, Gribbestad IS
BMC Cancer 2010 Aug 17;10:433. doi: 10.1186/1471-2407-10-433. PMID: 20716336Free PMC Article
Acute dyslipoproteinemia induced by interleukin-2: lecithin:cholesteryl acyltransferase, lipoprotein lipase, and hepatic lipase deficiencies.
Kwong LK, Ridinger DN, Bandhauer M, Ward JH, Samlowski WE, Iverius PH, Pritchard H, Wilson DE
J Clin Endocrinol Metab 1997 May;82(5):1572-81. doi: 10.1210/jcem.82.5.3937. PMID: 9141552
Improved lipoprotein surface and core lipid composition following intraperitoneal insulin delivery in insulin-dependent diabetes mellitus.
Bagdade JD, Dunn FL
Diabetes Metab 1996 Dec;22(6):420-6. PMID: 8985650

Clinical prediction guides

Nuclear Magnetic Resonance-Based Metabolomics and Risk of CKD.
Geng TT, Chen JX, Lu Q, Wang PL, Xia PF, Zhu K, Li Y, Guo KQ, Yang K, Liao YF, Zhou YF, Liu G, Pan A
Am J Kidney Dis 2024 Jan;83(1):9-17. Epub 2023 Sep 9 doi: 10.1053/j.ajkd.2023.05.014. PMID: 37678743
Antiphospholipid antibodies: discovery, definitions, detection and disease.
McIntyre JA, Wagenknecht DR, Faulk WP
Prog Lipid Res 2003 May;42(3):176-237. doi: 10.1016/s0163-7827(02)00048-6. PMID: 12689618
Correction of erythrocyte shape abnormalities in familial hypercholesterolemia after LDL-apheresis: does it influence cerebral hemodynamics?
Iannuzzi A, Bianciardi G, Faccenda F, Gnasso A, Scarpato N, Di Marino L, Iaccarino G, Simoes C, Sacchi G, Weber E
Heart Vessels 1997;12(5):234-40. doi: 10.1007/BF02766789. PMID: 9846809
Acute dyslipoproteinemia induced by interleukin-2: lecithin:cholesteryl acyltransferase, lipoprotein lipase, and hepatic lipase deficiencies.
Kwong LK, Ridinger DN, Bandhauer M, Ward JH, Samlowski WE, Iverius PH, Pritchard H, Wilson DE
J Clin Endocrinol Metab 1997 May;82(5):1572-81. doi: 10.1210/jcem.82.5.3937. PMID: 9141552
Band 3 and glycophorin are progressively aggregated in density-fractionated sickle and normal red blood cells. Evidence from rotational and lateral mobility studies.
Corbett JD, Golan DE
J Clin Invest 1993 Jan;91(1):208-17. doi: 10.1172/JCI116172. PMID: 8423219Free PMC Article

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