U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Atypical squamous metaplasia

MedGen UID:
90737
•Concept ID:
C0334030
•
Cell or Molecular Dysfunction
Synonyms: Atypical epidermoid metaplasia; Atypical Squamous Metaplasia; Squamous Metaplasia with Atypia
SNOMED CT: Atypical squamous metaplasia (63114009); Atypical epidermoid metaplasia (63114009)

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAtypical squamous metaplasia

Professional guidelines

PubMed

Atypical squamous epithelium in cytologic specimens from the pancreas: cytological differential diagnosis and clinical implications.
Layfield LJ, Cramer H, Madden J, Gopez EV, Liu K
Diagn Cytopathol 2001 Jul;25(1):38-42. doi: 10.1002/dc.1099. PMID: 11466811
Hematoporphyrin derivative and laser photoradiation in the treatment of lung cancer.
Hayata Y, Kato H, Konaka C, Ono J, Takizawa N
Chest 1982 Mar;81(3):269-77. doi: 10.1378/chest.81.3.269. PMID: 6276108

Recent clinical studies

Etiology

p16 Positive Histologically Bland Squamous Metaplasia of the Cervix: What does It Signify?
Goyal A, Ellenson LH, Pirog EC
Am J Surg Pathol 2020 Jan;44(1):129-139. doi: 10.1097/PAS.0000000000001364. PMID: 31498174
Utility of p16 Immunohistochemistry in Evaluating Negative Cervical Biopsies Following High-risk Pap Test Results.
Shain AF, Kwok S, Folkins AK, Kong CS
Am J Surg Pathol 2018 Jan;42(1):69-75. doi: 10.1097/PAS.0000000000000960. PMID: 29112019
Functional association of oestrogen receptors with HPV infection in cervical carcinogenesis.
Ramachandran B
Endocr Relat Cancer 2017 Apr;24(4):R99-R108. doi: 10.1530/ERC-16-0571. PMID: 28283546
Expression of keratins and carcinoembryonic antigen in bronchial squamous metaplasia and lung carcinomas.
Athanassiadou P, Psyhoyou H, Kyrkou K, Athanassiades P, Moulopoulos S
Acta Cytol 1995 Nov-Dec;39(6):1161-6. PMID: 7483992
Atypical metaplasia and incidence of bronchogenic carcinoma.
Vine MF, Schoenbach VJ, Hulka BS, Koch GG, Samsa G
Am J Epidemiol 1990 May;131(5):781-93. doi: 10.1093/oxfordjournals.aje.a115569. PMID: 2321623

Diagnosis

Performance of specific morphologic features in distinguishing low-grade squamous intraepithelial lesions from high-grade squamous intraepithelial lesions in borderline cases: a College of American Pathologists Cytopathology Committee multiobserver study.
Staats PN, Davey DD, Witt BL, Ghofrani M, Zhao C, Dodd LG, Goodrich K, Husain M, Kurtycz DFI, Russell DK, Shen RZ, Souers RJ, Tabatabai ZL, Crothers BA
J Am Soc Cytopathol 2022 Mar-Apr;11(2):102-113. Epub 2021 Nov 10 doi: 10.1016/j.jasc.2021.11.001. PMID: 34903496
p16 Positive Histologically Bland Squamous Metaplasia of the Cervix: What does It Signify?
Goyal A, Ellenson LH, Pirog EC
Am J Surg Pathol 2020 Jan;44(1):129-139. doi: 10.1097/PAS.0000000000001364. PMID: 31498174
Utility of p16 Immunohistochemistry in Evaluating Negative Cervical Biopsies Following High-risk Pap Test Results.
Shain AF, Kwok S, Folkins AK, Kong CS
Am J Surg Pathol 2018 Jan;42(1):69-75. doi: 10.1097/PAS.0000000000000960. PMID: 29112019
Atypical squamous epithelium in cytologic specimens from the pancreas: cytological differential diagnosis and clinical implications.
Layfield LJ, Cramer H, Madden J, Gopez EV, Liu K
Diagn Cytopathol 2001 Jul;25(1):38-42. doi: 10.1002/dc.1099. PMID: 11466811
Expression of keratins and carcinoembryonic antigen in bronchial squamous metaplasia and lung carcinomas.
Athanassiadou P, Psyhoyou H, Kyrkou K, Athanassiades P, Moulopoulos S
Acta Cytol 1995 Nov-Dec;39(6):1161-6. PMID: 7483992

Therapy

Functional association of oestrogen receptors with HPV infection in cervical carcinogenesis.
Ramachandran B
Endocr Relat Cancer 2017 Apr;24(4):R99-R108. doi: 10.1530/ERC-16-0571. PMID: 28283546
Atypical squamous metaplasia of seromas in breast needle aspirates from irradiated lumpectomy sites: a potential pitfall for false-positive diagnoses of carcinoma.
Saad RS, Silverman JF, Julian T, Clary KM, Sturgis CD
Diagn Cytopathol 2002 Feb;26(2):104-8. doi: 10.1002/dc.10054. PMID: 11813328
Cytologic changes of the respiratory tract in vineyard spraying workers.
Plamenac P, Santić Z, Nikulin A, Serdarević H
Eur J Respir Dis 1985 Jul;67(1):50-5. PMID: 4054256
Hematoporphyrin derivative and laser photoradiation in the treatment of lung cancer.
Hayata Y, Kato H, Konaka C, Ono J, Takizawa N
Chest 1982 Mar;81(3):269-77. doi: 10.1378/chest.81.3.269. PMID: 6276108
DES story: review and report.
Yoonessi M, Mariniello DA, Wieckowska WS, Angtuaco MG, Diesfeld P
N Y State J Med 1981 Feb;81(2):195-8. PMID: 6936633

Prognosis

Performance of specific morphologic features in distinguishing low-grade squamous intraepithelial lesions from high-grade squamous intraepithelial lesions in borderline cases: a College of American Pathologists Cytopathology Committee multiobserver study.
Staats PN, Davey DD, Witt BL, Ghofrani M, Zhao C, Dodd LG, Goodrich K, Husain M, Kurtycz DFI, Russell DK, Shen RZ, Souers RJ, Tabatabai ZL, Crothers BA
J Am Soc Cytopathol 2022 Mar-Apr;11(2):102-113. Epub 2021 Nov 10 doi: 10.1016/j.jasc.2021.11.001. PMID: 34903496
Utility of p16 Immunohistochemistry in Evaluating Negative Cervical Biopsies Following High-risk Pap Test Results.
Shain AF, Kwok S, Folkins AK, Kong CS
Am J Surg Pathol 2018 Jan;42(1):69-75. doi: 10.1097/PAS.0000000000000960. PMID: 29112019
Utility of HPV DNA detection in thin-layer, liquid-based tests with atypical squamous metaplasia.
Quddus MR, Zhang S, Sung CJ, Liu F, Neves T, Struminsky J, Singer DB
Acta Cytol 2002 Sep-Oct;46(5):808-12. doi: 10.1159/000327051. PMID: 12365211
Clinical evaluation of follow-up methods and results of atypical glandular cells of undetermined significance (AGUS) detected on cervicovaginal Pap smears.
Kim TJ, Kim HS, Park CT, Park IS, Hong SR, Park JS, Shim JU
Gynecol Oncol 1999 May;73(2):292-8. doi: 10.1006/gyno.1999.5360. PMID: 10329049
Atypical metaplasia and incidence of bronchogenic carcinoma.
Vine MF, Schoenbach VJ, Hulka BS, Koch GG, Samsa G
Am J Epidemiol 1990 May;131(5):781-93. doi: 10.1093/oxfordjournals.aje.a115569. PMID: 2321623

Clinical prediction guides

Performance of specific morphologic features in distinguishing low-grade squamous intraepithelial lesions from high-grade squamous intraepithelial lesions in borderline cases: a College of American Pathologists Cytopathology Committee multiobserver study.
Staats PN, Davey DD, Witt BL, Ghofrani M, Zhao C, Dodd LG, Goodrich K, Husain M, Kurtycz DFI, Russell DK, Shen RZ, Souers RJ, Tabatabai ZL, Crothers BA
J Am Soc Cytopathol 2022 Mar-Apr;11(2):102-113. Epub 2021 Nov 10 doi: 10.1016/j.jasc.2021.11.001. PMID: 34903496
Functional association of oestrogen receptors with HPV infection in cervical carcinogenesis.
Ramachandran B
Endocr Relat Cancer 2017 Apr;24(4):R99-R108. doi: 10.1530/ERC-16-0571. PMID: 28283546
Utility of HPV DNA detection in thin-layer, liquid-based tests with atypical squamous metaplasia.
Quddus MR, Zhang S, Sung CJ, Liu F, Neves T, Struminsky J, Singer DB
Acta Cytol 2002 Sep-Oct;46(5):808-12. doi: 10.1159/000327051. PMID: 12365211
Expression of keratins and carcinoembryonic antigen in bronchial squamous metaplasia and lung carcinomas.
Athanassiadou P, Psyhoyou H, Kyrkou K, Athanassiades P, Moulopoulos S
Acta Cytol 1995 Nov-Dec;39(6):1161-6. PMID: 7483992
Fiberoptic bronchoscopic laser photoradiation for tumor localization in lung cancer.
Hayata Y, Kato H, Konaka C, Ono J, Matsushima Y, Yoneyama K, Nishimiya K
Chest 1982 Jul;82(1):10-4. doi: 10.1378/chest.82.1.10. PMID: 6282545

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...