U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Sagittal sinus thrombosis

MedGen UID:
90927
•Concept ID:
C0338575
•
Disease or Syndrome
Synonyms: Sagittal Sinus Thromboses; Sagittal Sinus Thrombosis; Sinus Thromboses, Sagittal; Sinus Thrombosis, Sagittal; Thromboses, Sagittal Sinus; Thrombosis, Sagittal Sinus
SNOMED CT: Thrombosis of superior sagittal sinus (70607008); Thrombosis of superior longitudinal sinus (192760003); Sagittal sinus thrombosis (70607008); Cerebral venous thrombosis of sagittal sinus (70607008)
 
Monarch Initiative: MONDO:0002695

Definition

Formation or presence of a blood clot (thrombus) in the superior sagittal sinus or the inferior sagittal sinus. Sagittal sinus thrombosis can result from infections, hematological disorders, craniocerebral trauma; and neurosurgical procedures. Clinical features are primarily related to the increased intracranial pressure causing headache; nausea; and vomiting. Severe cases can evolve to seizures or coma. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSagittal sinus thrombosis

Professional guidelines

PubMed

Interventions for the treatment of brain radionecrosis after radiotherapy or radiosurgery.
Chung C, Bryant A, Brown PD
Cochrane Database Syst Rev 2018 Jul 9;7(7):CD011492. doi: 10.1002/14651858.CD011492.pub2. PMID: 29987845Free PMC Article
Intracranial hypertension caused by a depressed skull fracture resulting in superior sagittal sinus thrombosis in a pediatric patient: treatment with ventriculoperitoneal shunt insertion.
Forbes JA, Reig AS, Tomycz LD, Tulipan N
J Neurosurg Pediatr 2010 Jul;6(1):23-8. doi: 10.3171/2010.3.PEDS09441. PMID: 20593983
Thromboembolism after ovarian stimulation: successful management of a woman with superior sagittal sinus thrombosis after IVF and embryo transfer: case report.
Ou YC, Kao YL, Lai SL, Kung FT, Huang FJ, Chang SY, ChangChien CC
Hum Reprod 2003 Nov;18(11):2375-81. doi: 10.1093/humrep/deg470. PMID: 14585890

Recent clinical studies

Etiology

Coma in adult cerebral venous thrombosis: The BEAST study.
Ranjan R, Ken-Dror G, Martinelli I, Grandone E, Hiltunen S, Lindgren E, Margaglione M, Duchez VLC, Triquenot Bagan A, Zedde M, Giannini N, Ruigrok YM, Worrall BB, Majersik JJ, Putaala J, Haapaniemi E, Zuurbier SM, Brouwer MC, Passamonti SM, Abbattista M, Bucciarelli P, Lemmens R, Pappalardo E, Costa P, Colombi M, Aguiar de Sousa D, Rodrigues S, Canhão P, Tkach A, Santacroce R, Favuzzi G, Arauz A, Colaizzo D, Spengos K, Hodge A, Ditta R, Pezzini A, Coutinho JM, Thijs V, Jood K, Tatlisumak T, Ferro JM, Sharma P
Eur J Neurol 2024 Aug;31(8):e16311. Epub 2024 Apr 22 doi: 10.1111/ene.16311. PMID: 38646961Free PMC Article
Acute Seizures in Cerebral Venous Sinus Thrombosis: Risk Factors and Prognosis.
Gazioglu S, Yildirim A, Kokturk EG, Seker D, Altunayoglu Cakmak V, Velioglu SK
Neurologist 2020 Sep;25(5):126-130. doi: 10.1097/NRL.0000000000000288. PMID: 32925483
Cerebral Venous Sinus Thrombosis Score and its Correlation with Clinical and MRI Findings.
Kalita J, Singh VK, Jain N, Misra UK, Kumar S
J Stroke Cerebrovasc Dis 2019 Nov;28(11):104324. Epub 2019 Aug 15 doi: 10.1016/j.jstrokecerebrovasdis.2019.104324. PMID: 31422004
Neonatal stroke.
Rutherford MA, Ramenghi LA, Cowan FM
Arch Dis Child Fetal Neonatal Ed 2012 Sep;97(5):F377-84. doi: 10.1136/fetalneonatal-2010-196451. PMID: 22933099
Septic cortical thrombophlebitis.
DiNubile MJ, Boom WH, Southwick FS
J Infect Dis 1990 Jun;161(6):1216-20. doi: 10.1093/infdis/161.6.1216. PMID: 2189005

Diagnosis

PHOTORECEPTOR DAMAGE IN TERSON SYNDROME.
Szeligowski T, Fu DJ, Fernandez-Ledo N, Birtel J, Aslam SA, Patel CK, Xue K, Charbel Issa P
Retina 2023 Sep 1;43(9):1557-1562. doi: 10.1097/IAE.0000000000003842. PMID: 37253246
Acute Seizures in Cerebral Venous Sinus Thrombosis: Risk Factors and Prognosis.
Gazioglu S, Yildirim A, Kokturk EG, Seker D, Altunayoglu Cakmak V, Velioglu SK
Neurologist 2020 Sep;25(5):126-130. doi: 10.1097/NRL.0000000000000288. PMID: 32925483
Cerebral Venous Sinus Thrombosis Score and its Correlation with Clinical and MRI Findings.
Kalita J, Singh VK, Jain N, Misra UK, Kumar S
J Stroke Cerebrovasc Dis 2019 Nov;28(11):104324. Epub 2019 Aug 15 doi: 10.1016/j.jstrokecerebrovasdis.2019.104324. PMID: 31422004
Neonatal stroke.
Rutherford MA, Ramenghi LA, Cowan FM
Arch Dis Child Fetal Neonatal Ed 2012 Sep;97(5):F377-84. doi: 10.1136/fetalneonatal-2010-196451. PMID: 22933099
Septic cortical thrombophlebitis.
DiNubile MJ, Boom WH, Southwick FS
J Infect Dis 1990 Jun;161(6):1216-20. doi: 10.1093/infdis/161.6.1216. PMID: 2189005

Therapy

Rivaroxaban for severe superior sagittal sinus thrombosis in a child with ALL.
Yamamoto M, Akane Y, Hamada R, Kabutoya H, Igarashi K, Kim S, Tsugawa T
Int J Hematol 2023 Sep;118(3):309-310. Epub 2023 Jul 14 doi: 10.1007/s12185-023-03640-9. PMID: 37450173
Infectious thrombosis of the superior sagittal sinus with subarachnoid hemorrhage: A case report.
Li J, Li S, Zhang J, Wen Y, Wang K, Luan X, Xiang W, Chen L, Zhou J
Medicine (Baltimore) 2023 Mar 10;102(10):e33218. doi: 10.1097/MD.0000000000033218. PMID: 36897700Free PMC Article
The role of anticoagulation for superior sagittal sinus thrombosis following craniotomy for resection of parasagittal/parafalcine meningiomas.
Jimenez AE, Khalafallah AM, Botros D, Horowitz MA, Azmeh O, Lam S, Oliveira LAP, Chakravarti S, Liu S, Wu E, Wei O, Porras JL, Bettegowda C, Tamargo RJ, Brem H, Mukherjee D
J Neurooncol 2022 Jan;156(2):341-352. Epub 2021 Dec 2 doi: 10.1007/s11060-021-03916-2. PMID: 34855096
Superior sagittal sinus thrombosis after spinal anesthesia.
Daqqaq TS, Naqshabandi AA, Rajih ES
Neurosciences (Riyadh) 2020 Jul;25(3):210-213. doi: 10.17712/nsj.2020.3.20200003. PMID: 32683402Free PMC Article
Superior sagittal sinus thrombosis and pulmonary embolism: a syndrome rediscovered.
Diaz JM, Schiffman JS, Urban ES, Maccario M
Acta Neurol Scand 1992 Oct;86(4):390-6. doi: 10.1111/j.1600-0404.1992.tb05106.x. PMID: 1455986

Prognosis

Coma in adult cerebral venous thrombosis: The BEAST study.
Ranjan R, Ken-Dror G, Martinelli I, Grandone E, Hiltunen S, Lindgren E, Margaglione M, Duchez VLC, Triquenot Bagan A, Zedde M, Giannini N, Ruigrok YM, Worrall BB, Majersik JJ, Putaala J, Haapaniemi E, Zuurbier SM, Brouwer MC, Passamonti SM, Abbattista M, Bucciarelli P, Lemmens R, Pappalardo E, Costa P, Colombi M, Aguiar de Sousa D, Rodrigues S, Canhão P, Tkach A, Santacroce R, Favuzzi G, Arauz A, Colaizzo D, Spengos K, Hodge A, Ditta R, Pezzini A, Coutinho JM, Thijs V, Jood K, Tatlisumak T, Ferro JM, Sharma P
Eur J Neurol 2024 Aug;31(8):e16311. Epub 2024 Apr 22 doi: 10.1111/ene.16311. PMID: 38646961Free PMC Article
The role of anticoagulation for superior sagittal sinus thrombosis following craniotomy for resection of parasagittal/parafalcine meningiomas.
Jimenez AE, Khalafallah AM, Botros D, Horowitz MA, Azmeh O, Lam S, Oliveira LAP, Chakravarti S, Liu S, Wu E, Wei O, Porras JL, Bettegowda C, Tamargo RJ, Brem H, Mukherjee D
J Neurooncol 2022 Jan;156(2):341-352. Epub 2021 Dec 2 doi: 10.1007/s11060-021-03916-2. PMID: 34855096
Acute Seizures in Cerebral Venous Sinus Thrombosis: Risk Factors and Prognosis.
Gazioglu S, Yildirim A, Kokturk EG, Seker D, Altunayoglu Cakmak V, Velioglu SK
Neurologist 2020 Sep;25(5):126-130. doi: 10.1097/NRL.0000000000000288. PMID: 32925483
Acute symptomatic seizures in cerebral venous thrombosis.
Lindgren E, Silvis SM, Hiltunen S, Heldner MR, Serrano F, de Scisco M, Zelano J, Zuurbier SM, Sánchez van Kammen M, Mansour M, Aguiar de Sousa D, Penas S, Al-Asady S, Ekizoglu E, Redfors P, Ahmed A, Yesilot N, Ghiasian M, Barboza MA, Arnao V, Aridon P, Punter MNM, Ferro JM, Kleinig T, Arauz A, Tatlisumak T, Arnold M, Putaala J, Coutinho JM, Jood K
Neurology 2020 Sep 22;95(12):e1706-e1715. Epub 2020 Aug 5 doi: 10.1212/WNL.0000000000010577. PMID: 32759191
Cerebral Venous Sinus Thrombosis Score and its Correlation with Clinical and MRI Findings.
Kalita J, Singh VK, Jain N, Misra UK, Kumar S
J Stroke Cerebrovasc Dis 2019 Nov;28(11):104324. Epub 2019 Aug 15 doi: 10.1016/j.jstrokecerebrovasdis.2019.104324. PMID: 31422004

Clinical prediction guides

Coma in adult cerebral venous thrombosis: The BEAST study.
Ranjan R, Ken-Dror G, Martinelli I, Grandone E, Hiltunen S, Lindgren E, Margaglione M, Duchez VLC, Triquenot Bagan A, Zedde M, Giannini N, Ruigrok YM, Worrall BB, Majersik JJ, Putaala J, Haapaniemi E, Zuurbier SM, Brouwer MC, Passamonti SM, Abbattista M, Bucciarelli P, Lemmens R, Pappalardo E, Costa P, Colombi M, Aguiar de Sousa D, Rodrigues S, Canhão P, Tkach A, Santacroce R, Favuzzi G, Arauz A, Colaizzo D, Spengos K, Hodge A, Ditta R, Pezzini A, Coutinho JM, Thijs V, Jood K, Tatlisumak T, Ferro JM, Sharma P
Eur J Neurol 2024 Aug;31(8):e16311. Epub 2024 Apr 22 doi: 10.1111/ene.16311. PMID: 38646961Free PMC Article
PHOTORECEPTOR DAMAGE IN TERSON SYNDROME.
Szeligowski T, Fu DJ, Fernandez-Ledo N, Birtel J, Aslam SA, Patel CK, Xue K, Charbel Issa P
Retina 2023 Sep 1;43(9):1557-1562. doi: 10.1097/IAE.0000000000003842. PMID: 37253246
Acute Seizures in Cerebral Venous Sinus Thrombosis: Risk Factors and Prognosis.
Gazioglu S, Yildirim A, Kokturk EG, Seker D, Altunayoglu Cakmak V, Velioglu SK
Neurologist 2020 Sep;25(5):126-130. doi: 10.1097/NRL.0000000000000288. PMID: 32925483
Cerebral Venous Sinus Thrombosis Score and its Correlation with Clinical and MRI Findings.
Kalita J, Singh VK, Jain N, Misra UK, Kumar S
J Stroke Cerebrovasc Dis 2019 Nov;28(11):104324. Epub 2019 Aug 15 doi: 10.1016/j.jstrokecerebrovasdis.2019.104324. PMID: 31422004
Interventions for the treatment of brain radionecrosis after radiotherapy or radiosurgery.
Chung C, Bryant A, Brown PD
Cochrane Database Syst Rev 2018 Jul 9;7(7):CD011492. doi: 10.1002/14651858.CD011492.pub2. PMID: 29987845Free PMC Article

Recent systematic reviews

Predictors of early intracerebral hemorrhage in patients with cerebral sinus venous thrombosis: Systematic review and meta-analysis.
Gharaibeh K, Aladamat N, Ali A, Mierzwa AT, Pervez H, Jumaa M, Zaidi S
J Stroke Cerebrovasc Dis 2024 Dec;33(12):108028. Epub 2024 Sep 28 doi: 10.1016/j.jstrokecerebrovasdis.2024.108028. PMID: 39343153
Interventions for the treatment of brain radionecrosis after radiotherapy or radiosurgery.
Chung C, Bryant A, Brown PD
Cochrane Database Syst Rev 2018 Jul 9;7(7):CD011492. doi: 10.1002/14651858.CD011492.pub2. PMID: 29987845Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...