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Intracranial thrombosis

MedGen UID:
199820
•Concept ID:
C0752143
•
Disease or Syndrome
Synonyms: Intracranial Thromboses; Intracranial Thrombosis; Intracranial Thrombus; Thromboses, Intracranial; Thrombosis, Intracranial; Thrombus, Intracranial
 
Monarch Initiative: MONDO:0002907

Definition

Formation or presence of a blood clot (thrombus) in a blood vessel within the skull. Intracranial thrombosis can lead to thrombotic occlusions and brain infarction. The majority of the thrombotic occlusions are associated with atherosclerosis. [from MONDO]

Professional guidelines

PubMed

Diagnosis and Management of Cerebral Venous Thrombosis: A Scientific Statement From the American Heart Association.
Saposnik G, Bushnell C, Coutinho JM, Field TS, Furie KL, Galadanci N, Kam W, Kirkham FC, McNair ND, Singhal AB, Thijs V, Yang VXD; American Heart Association Stroke Council; Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation; Council on Cardiovascular and Stroke Nursing; and Council on Hypertension
Stroke 2024 Mar;55(3):e77-e90. Epub 2024 Jan 29 doi: 10.1161/STR.0000000000000456. PMID: 38284265
Endovascular treatment of cerebral sinus thrombosis due to vaccine-induced immune thrombotic thrombocytopenia.
Weller J, Krzywicka K, van de Munckhof A, Dorn F, Althaus K, Bode FJ, Bandettini di Poggio M, Buck B, Kleinig T, Cordonnier C, Dizonno V, Duan J, Elkady A, Chew BLA, Garcia-Esperon C, Field TS, Legault C, Morin Martin M, Michalski D, Pelz J, Schoenenberger S, Nagel S, Petruzzellis M, Raposo N, Skjelland M, Zimatore DS, Aaron S, Sanchez van Kammen M, Aguiar de Sousa D, Lindgren E, Jood K, Scutelnic A, Heldner MR, Poli S, Arauz A, Conforto AB, Putaala J, Tatlisumak T, Arnold M, Coutinho JM, Günther A, Zimmermann J, Ferro JM
Eur Stroke J 2024 Mar;9(1):105-113. Epub 2023 Sep 28 doi: 10.1177/23969873231202363. PMID: 37771138Free PMC Article
Thromboembolism after ovarian stimulation: successful management of a woman with superior sagittal sinus thrombosis after IVF and embryo transfer: case report.
Ou YC, Kao YL, Lai SL, Kung FT, Huang FJ, Chang SY, ChangChien CC
Hum Reprod 2003 Nov;18(11):2375-81. doi: 10.1093/humrep/deg470. PMID: 14585890

Recent clinical studies

Etiology

Diagnosis and Treatment of Cerebral Venous Thrombosis.
Liberman AL
Continuum (Minneap Minn) 2023 Apr 1;29(2):519-539. doi: 10.1212/CON.0000000000001211. PMID: 37039408
Cerebral Venous Thrombosis.
Aamodt AH, Skattør TH
Semin Thromb Hemost 2022 Apr;48(3):309-317. Epub 2022 Feb 15 doi: 10.1055/s-0042-1742738. PMID: 35170006
Cerebral venous thrombosis.
Cohen O, Pegoraro S, Ageno W
Minerva Med 2021 Dec;112(6):755-766. Epub 2021 Feb 8 doi: 10.23736/S0026-4806.21.07353-5. PMID: 33555165
Cerebral venous thrombosis: a practical guide.
Ulivi L, Squitieri M, Cohen H, Cowley P, Werring DJ
Pract Neurol 2020 Oct;20(5):356-367. doi: 10.1136/practneurol-2019-002415. PMID: 32958591
Cerebral Venous Thrombosis: an Update.
Ferro JM, Aguiar de Sousa D
Curr Neurol Neurosci Rep 2019 Aug 23;19(10):74. doi: 10.1007/s11910-019-0988-x. PMID: 31440838

Diagnosis

Cerebral venous thrombosis.
Cohen O, Pegoraro S, Ageno W
Minerva Med 2021 Dec;112(6):755-766. Epub 2021 Feb 8 doi: 10.23736/S0026-4806.21.07353-5. PMID: 33555165
Cerebral venous thrombosis: a practical guide.
Ulivi L, Squitieri M, Cohen H, Cowley P, Werring DJ
Pract Neurol 2020 Oct;20(5):356-367. doi: 10.1136/practneurol-2019-002415. PMID: 32958591
Cerebral Venous Thrombosis: an Update.
Ferro JM, Aguiar de Sousa D
Curr Neurol Neurosci Rep 2019 Aug 23;19(10):74. doi: 10.1007/s11910-019-0988-x. PMID: 31440838
Cerebral venous thrombosis.
Silvis SM, de Sousa DA, Ferro JM, Coutinho JM
Nat Rev Neurol 2017 Sep;13(9):555-565. Epub 2017 Aug 18 doi: 10.1038/nrneurol.2017.104. PMID: 28820187
Diagnosis and management of cerebral venous thrombosis: a statement for healthcare professionals from the American Heart Association/American Stroke Association.
Saposnik G, Barinagarrementeria F, Brown RD Jr, Bushnell CD, Cucchiara B, Cushman M, deVeber G, Ferro JM, Tsai FY; American Heart Association Stroke Council and the Council on Epidemiology and Prevention
Stroke 2011 Apr;42(4):1158-92. Epub 2011 Feb 3 doi: 10.1161/STR.0b013e31820a8364. PMID: 21293023

Therapy

Ischemic Stroke in the Young.
Berkman SA, Song SS
Clin Appl Thromb Hemost 2021 Jan-Dec;27:10760296211002274. doi: 10.1177/10760296211002274. PMID: 33870763Free PMC Article
Cerebral venous thrombosis.
Cohen O, Pegoraro S, Ageno W
Minerva Med 2021 Dec;112(6):755-766. Epub 2021 Feb 8 doi: 10.23736/S0026-4806.21.07353-5. PMID: 33555165
Cerebral venous thrombosis: a practical guide.
Ulivi L, Squitieri M, Cohen H, Cowley P, Werring DJ
Pract Neurol 2020 Oct;20(5):356-367. doi: 10.1136/practneurol-2019-002415. PMID: 32958591
Cerebral Venous Thrombosis: an Update.
Ferro JM, Aguiar de Sousa D
Curr Neurol Neurosci Rep 2019 Aug 23;19(10):74. doi: 10.1007/s11910-019-0988-x. PMID: 31440838
Cerebral venous thrombosis.
Silvis SM, de Sousa DA, Ferro JM, Coutinho JM
Nat Rev Neurol 2017 Sep;13(9):555-565. Epub 2017 Aug 18 doi: 10.1038/nrneurol.2017.104. PMID: 28820187

Prognosis

Diagnosis and Management of Cerebral Venous Thrombosis: A Scientific Statement From the American Heart Association.
Saposnik G, Bushnell C, Coutinho JM, Field TS, Furie KL, Galadanci N, Kam W, Kirkham FC, McNair ND, Singhal AB, Thijs V, Yang VXD; American Heart Association Stroke Council; Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation; Council on Cardiovascular and Stroke Nursing; and Council on Hypertension
Stroke 2024 Mar;55(3):e77-e90. Epub 2024 Jan 29 doi: 10.1161/STR.0000000000000456. PMID: 38284265
Cerebral Venous Thrombosis.
Ropper AH, Klein JP
N Engl J Med 2021 Jul 1;385(1):59-64. doi: 10.1056/NEJMra2106545. PMID: 34192432
Cerebral venous thrombosis: a practical guide.
Ulivi L, Squitieri M, Cohen H, Cowley P, Werring DJ
Pract Neurol 2020 Oct;20(5):356-367. doi: 10.1136/practneurol-2019-002415. PMID: 32958591
Cerebral Venous Thrombosis: an Update.
Ferro JM, Aguiar de Sousa D
Curr Neurol Neurosci Rep 2019 Aug 23;19(10):74. doi: 10.1007/s11910-019-0988-x. PMID: 31440838
Cerebral venous thrombosis.
Silvis SM, de Sousa DA, Ferro JM, Coutinho JM
Nat Rev Neurol 2017 Sep;13(9):555-565. Epub 2017 Aug 18 doi: 10.1038/nrneurol.2017.104. PMID: 28820187

Clinical prediction guides

Cerebral venous thrombosis.
Ordieres-Ortega L, Moragón-Ledesma S, Demelo-Rodríguez P
Rev Clin Esp (Barc) 2024 Apr;224(4):237-244. Epub 2024 Feb 28 doi: 10.1016/j.rceng.2024.02.015. PMID: 38428733
Diagnosis and Management of Cerebral Venous Thrombosis: A Scientific Statement From the American Heart Association.
Saposnik G, Bushnell C, Coutinho JM, Field TS, Furie KL, Galadanci N, Kam W, Kirkham FC, McNair ND, Singhal AB, Thijs V, Yang VXD; American Heart Association Stroke Council; Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation; Council on Cardiovascular and Stroke Nursing; and Council on Hypertension
Stroke 2024 Mar;55(3):e77-e90. Epub 2024 Jan 29 doi: 10.1161/STR.0000000000000456. PMID: 38284265
Intracranial hypertension after cerebral venous thrombosis-Risk factors and outcomes.
Wei H, Jiang H, Zhou Y, Liu L, Zhou C, Ji X
CNS Neurosci Ther 2023 Sep;29(9):2540-2547. Epub 2023 Mar 28 doi: 10.1111/cns.14194. PMID: 36987606Free PMC Article
European Stroke Organization guideline for the diagnosis and treatment of cerebral venous thrombosis - endorsed by the European Academy of Neurology.
Ferro JM, Bousser MG, Canhão P, Coutinho JM, Crassard I, Dentali F, di Minno M, Maino A, Martinelli I, Masuhr F, Aguiar de Sousa D, Stam J; European Stroke Organization
Eur J Neurol 2017 Oct;24(10):1203-1213. Epub 2017 Aug 20 doi: 10.1111/ene.13381. PMID: 28833980
Cerebral venous thrombosis.
Coutinho JM
J Thromb Haemost 2015 Jun;13 Suppl 1:S238-44. doi: 10.1111/jth.12945. PMID: 26149030

Recent systematic reviews

Decompressive surgery in cerebral venous thrombosis: A systematic review and meta-analysis.
Misra S, Sudhir P, Nath M, Sharma VK, Vibha D
Eur J Clin Invest 2023 Apr;53(4):e13944. Epub 2023 Jan 5 doi: 10.1111/eci.13944. PMID: 36576370
Direct Oral Anticoagulants Versus Vitamin K Antagonists in Cerebral Venous Thrombosis: A Systematic Review and Meta-Analysis.
Yaghi S, Saldanha IJ, Misquith C, Zaidat B, Shah A, Joudi K, Persaud B, Abdul Khalek F, Shu L, de Havenon A, Mistry EA, Bakradze E, Goldstein ED, Reagan J, Theodorou A, Palaiodimou L, Furie K, Field TS, Tsivgoulis G, Mac Grory B
Stroke 2022 Oct;53(10):3014-3024. Epub 2022 Aug 8 doi: 10.1161/STROKEAHA.122.039579. PMID: 35938419
Late epileptic seizures following cerebral venous thrombosis: a systematic review and meta-analysis.
Gasparini S, Neri S, Brigo F, Cianci V, Mammì A, Pascarella A, Manzo L, Benna P, Striano P, Martino T, Romoli M, Muccioli L, Nilo A, Valente M, Cagnetti C, Labate A, Gambardella A, Pisani F, Casciato S, Di Gennaro G, Belcastro V, Aguglia U, Ferlazzo E; Epilepsy Study Group of the Italian Neurological Society
Neurol Sci 2022 Sep;43(9):5229-5236. Epub 2022 May 31 doi: 10.1007/s10072-022-06148-y. PMID: 35639217Free PMC Article
Cerebral venous thrombosis and severe acute respiratory syndrome coronavirus-2 infection: A systematic review and meta-analysis.
Baldini T, Asioli GM, Romoli M, Carvalho Dias M, Schulte EC, Hauer L, Aguiar De Sousa D, Sellner J, Zini A
Eur J Neurol 2021 Oct;28(10):3478-3490. Epub 2021 Feb 2 doi: 10.1111/ene.14727. PMID: 33426733Free PMC Article
Isolated cortical vein thrombosis: systematic review of case reports and case series.
Coutinho JM, Gerritsma JJ, Zuurbier SM, Stam J
Stroke 2014 Jun;45(6):1836-8. Epub 2014 Apr 17 doi: 10.1161/STROKEAHA.113.004414. PMID: 24743438

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