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Intracranial thrombosis

MedGen UID:
199820
Concept ID:
C0752143
Disease or Syndrome
Synonyms: Intracranial Thromboses; Intracranial Thrombosis; Intracranial Thrombus; Thromboses, Intracranial; Thrombosis, Intracranial; Thrombus, Intracranial
 
Monarch Initiative: MONDO:0002907

Definition

Formation or presence of a blood clot (thrombus) in a blood vessel within the skull. Intracranial thrombosis can lead to thrombotic occlusions and brain infarction. The majority of the thrombotic occlusions are associated with atherosclerosis. [from MONDO]

Professional guidelines

PubMed

Saposnik G, Bushnell C, Coutinho JM, Field TS, Furie KL, Galadanci N, Kam W, Kirkham FC, McNair ND, Singhal AB, Thijs V, Yang VXD; American Heart Association Stroke Council; Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation; Council on Cardiovascular and Stroke Nursing; and Council on Hypertension
Stroke 2024 Mar;55(3):e77-e90. Epub 2024 Jan 29 doi: 10.1161/STR.0000000000000456. PMID: 38284265
Weller J, Krzywicka K, van de Munckhof A, Dorn F, Althaus K, Bode FJ, Bandettini di Poggio M, Buck B, Kleinig T, Cordonnier C, Dizonno V, Duan J, Elkady A, Chew BLA, Garcia-Esperon C, Field TS, Legault C, Morin Martin M, Michalski D, Pelz J, Schoenenberger S, Nagel S, Petruzzellis M, Raposo N, Skjelland M, Zimatore DS, Aaron S, Sanchez van Kammen M, Aguiar de Sousa D, Lindgren E, Jood K, Scutelnic A, Heldner MR, Poli S, Arauz A, Conforto AB, Putaala J, Tatlisumak T, Arnold M, Coutinho JM, Günther A, Zimmermann J, Ferro JM
Eur Stroke J 2024 Mar;9(1):105-113. Epub 2023 Sep 28 doi: 10.1177/23969873231202363. PMID: 37771138Free PMC Article
Ou YC, Kao YL, Lai SL, Kung FT, Huang FJ, Chang SY, ChangChien CC
Hum Reprod 2003 Nov;18(11):2375-81. doi: 10.1093/humrep/deg470. PMID: 14585890

Recent clinical studies

Etiology

Liberman AL
Continuum (Minneap Minn) 2023 Apr 1;29(2):519-539. doi: 10.1212/CON.0000000000001211. PMID: 37039408
Aamodt AH, Skattør TH
Semin Thromb Hemost 2022 Apr;48(3):309-317. Epub 2022 Feb 15 doi: 10.1055/s-0042-1742738. PMID: 35170006
Cohen O, Pegoraro S, Ageno W
Minerva Med 2021 Dec;112(6):755-766. Epub 2021 Feb 8 doi: 10.23736/S0026-4806.21.07353-5. PMID: 33555165
Ulivi L, Squitieri M, Cohen H, Cowley P, Werring DJ
Pract Neurol 2020 Oct;20(5):356-367. doi: 10.1136/practneurol-2019-002415. PMID: 32958591
Ferro JM, Aguiar de Sousa D
Curr Neurol Neurosci Rep 2019 Aug 23;19(10):74. doi: 10.1007/s11910-019-0988-x. PMID: 31440838

Diagnosis

Saposnik G, Bushnell C, Coutinho JM, Field TS, Furie KL, Galadanci N, Kam W, Kirkham FC, McNair ND, Singhal AB, Thijs V, Yang VXD; American Heart Association Stroke Council; Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation; Council on Cardiovascular and Stroke Nursing; and Council on Hypertension
Stroke 2024 Mar;55(3):e77-e90. Epub 2024 Jan 29 doi: 10.1161/STR.0000000000000456. PMID: 38284265
Cohen O, Pegoraro S, Ageno W
Minerva Med 2021 Dec;112(6):755-766. Epub 2021 Feb 8 doi: 10.23736/S0026-4806.21.07353-5. PMID: 33555165
Ulivi L, Squitieri M, Cohen H, Cowley P, Werring DJ
Pract Neurol 2020 Oct;20(5):356-367. doi: 10.1136/practneurol-2019-002415. PMID: 32958591
Ferro JM, Aguiar de Sousa D
Curr Neurol Neurosci Rep 2019 Aug 23;19(10):74. doi: 10.1007/s11910-019-0988-x. PMID: 31440838
Saposnik G, Barinagarrementeria F, Brown RD Jr, Bushnell CD, Cucchiara B, Cushman M, deVeber G, Ferro JM, Tsai FY; American Heart Association Stroke Council and the Council on Epidemiology and Prevention
Stroke 2011 Apr;42(4):1158-92. Epub 2011 Feb 3 doi: 10.1161/STR.0b013e31820a8364. PMID: 21293023

Therapy

Moraes Junior AAA, Conforto AB
Arq Neuropsiquiatr 2022 May;80(5 Suppl 1):53-59. doi: 10.1590/0004-282X-ANP-2022-S108. PMID: 35976298Free PMC Article
Berkman SA, Song SS
Clin Appl Thromb Hemost 2021 Jan-Dec;27:10760296211002274. doi: 10.1177/10760296211002274. PMID: 33870763Free PMC Article
Cohen O, Pegoraro S, Ageno W
Minerva Med 2021 Dec;112(6):755-766. Epub 2021 Feb 8 doi: 10.23736/S0026-4806.21.07353-5. PMID: 33555165
Ferro JM, Aguiar de Sousa D
Curr Neurol Neurosci Rep 2019 Aug 23;19(10):74. doi: 10.1007/s11910-019-0988-x. PMID: 31440838
Silvis SM, de Sousa DA, Ferro JM, Coutinho JM
Nat Rev Neurol 2017 Sep;13(9):555-565. Epub 2017 Aug 18 doi: 10.1038/nrneurol.2017.104. PMID: 28820187

Prognosis

Saposnik G, Bushnell C, Coutinho JM, Field TS, Furie KL, Galadanci N, Kam W, Kirkham FC, McNair ND, Singhal AB, Thijs V, Yang VXD; American Heart Association Stroke Council; Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation; Council on Cardiovascular and Stroke Nursing; and Council on Hypertension
Stroke 2024 Mar;55(3):e77-e90. Epub 2024 Jan 29 doi: 10.1161/STR.0000000000000456. PMID: 38284265
Ropper AH, Klein JP
N Engl J Med 2021 Jul 1;385(1):59-64. doi: 10.1056/NEJMra2106545. PMID: 34192432
Ulivi L, Squitieri M, Cohen H, Cowley P, Werring DJ
Pract Neurol 2020 Oct;20(5):356-367. doi: 10.1136/practneurol-2019-002415. PMID: 32958591
Ferro JM, Aguiar de Sousa D
Curr Neurol Neurosci Rep 2019 Aug 23;19(10):74. doi: 10.1007/s11910-019-0988-x. PMID: 31440838
Silvis SM, de Sousa DA, Ferro JM, Coutinho JM
Nat Rev Neurol 2017 Sep;13(9):555-565. Epub 2017 Aug 18 doi: 10.1038/nrneurol.2017.104. PMID: 28820187

Clinical prediction guides

Ordieres-Ortega L, Moragón-Ledesma S, Demelo-Rodríguez P
Rev Clin Esp (Barc) 2024 Apr;224(4):237-244. Epub 2024 Feb 28 doi: 10.1016/j.rceng.2024.02.015. PMID: 38428733
Saposnik G, Bushnell C, Coutinho JM, Field TS, Furie KL, Galadanci N, Kam W, Kirkham FC, McNair ND, Singhal AB, Thijs V, Yang VXD; American Heart Association Stroke Council; Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation; Council on Cardiovascular and Stroke Nursing; and Council on Hypertension
Stroke 2024 Mar;55(3):e77-e90. Epub 2024 Jan 29 doi: 10.1161/STR.0000000000000456. PMID: 38284265
Coutinho JM, Zuurbier SM, Bousser MG, Ji X, Canhão P, Roos YB, Crassard I, Nunes AP, Uyttenboogaart M, Chen J, Emmer BJ, Roosendaal SD, Houdart E, Reekers JA, van den Berg R, de Haan RJ, Majoie CB, Ferro JM, Stam J; TO-ACT investigators
JAMA Neurol 2020 Aug 1;77(8):966-973. doi: 10.1001/jamaneurol.2020.1022. PMID: 32421159Free PMC Article
Ferro JM, Bousser MG, Canhão P, Coutinho JM, Crassard I, Dentali F, di Minno M, Maino A, Martinelli I, Masuhr F, Aguiar de Sousa D, Stam J; European Stroke Organization
Eur J Neurol 2017 Oct;24(10):1203-1213. Epub 2017 Aug 20 doi: 10.1111/ene.13381. PMID: 28833980
Coutinho JM
J Thromb Haemost 2015 Jun;13 Suppl 1:S238-44. doi: 10.1111/jth.12945. PMID: 26149030

Recent systematic reviews

Yaghi S, Saldanha IJ, Misquith C, Zaidat B, Shah A, Joudi K, Persaud B, Abdul Khalek F, Shu L, de Havenon A, Mistry EA, Bakradze E, Goldstein ED, Reagan J, Theodorou A, Palaiodimou L, Furie K, Field TS, Tsivgoulis G, Mac Grory B
Stroke 2022 Oct;53(10):3014-3024. Epub 2022 Aug 8 doi: 10.1161/STROKEAHA.122.039579. PMID: 35938419
Baldini T, Asioli GM, Romoli M, Carvalho Dias M, Schulte EC, Hauer L, Aguiar De Sousa D, Sellner J, Zini A
Eur J Neurol 2021 Oct;28(10):3478-3490. Epub 2021 Feb 2 doi: 10.1111/ene.14727. PMID: 33426733Free PMC Article
Aguiar de Sousa D, Lucas Neto L, Canhão P, Ferro JM
Stroke 2018 Aug;49(8):1828-1835. doi: 10.1161/STROKEAHA.118.022129. PMID: 30021808
Coutinho JM, Gerritsma JJ, Zuurbier SM, Stam J
Stroke 2014 Jun;45(6):1836-8. Epub 2014 Apr 17 doi: 10.1161/STROKEAHA.113.004414. PMID: 24743438
Viegas LD, Stolz E, Canhão P, Ferro JM
Cerebrovasc Dis 2014;37(1):43-50. Epub 2013 Dec 18 doi: 10.1159/000356840. PMID: 24356180

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