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Intracranial sinus thrombosis

MedGen UID:
20771
•Concept ID:
C0037198
•
Disease or Syndrome
Synonyms: Cranial Sinus Thromboses; Cranial Sinus Thrombosis; Intracranial Sinus Thromboses; Intracranial Sinus Thrombosis; Sinus Thromboses; Sinus Thromboses, Cranial; Sinus Thromboses, Intracranial; Sinus Thrombosis; Sinus Thrombosis, Cranial; Sinus Thrombosis, Intracranial; Thromboses, Cranial Sinus; Thromboses, Intracranial Sinus; Thromboses, Sinus; Thrombosis, Cranial Sinus; Thrombosis, Intracranial Sinus; Thrombosis, Sinus; Venous Sinus Thrombosis, Cranial
 
Monarch Initiative: MONDO:0002692

Definition

Formation or presence of a blood clot (thrombus) in the cranial sinuses, large endothelium-lined venous channels situated within the skull. Intracranial sinuses, also called cranial venous sinuses, include the superior sagittal, cavernous, lateral, petrous sinuses, and many others. Cranial sinus thrombosis can lead to severe headache; seizure; and other neurological defects. [from MONDO]

Professional guidelines

PubMed

Cerebral angiography as a tool for diagnosis and management of idiopathic intracranial hypertension syndrome.
Montoya-Casella A, Vargas-Escamilla WR, Gómez-Martínez A, Herrera-Trujillo A
Clin Imaging 2022 Aug;88:53-58. Epub 2022 May 2 doi: 10.1016/j.clinimag.2022.04.014. PMID: 35643043
The management of elevated intracranial pressure and sinus vein thrombosis associated with mastoiditis: the experience of eighteen patients.
Havalı C, İnce H, Gündoğdu EB, Gürkaş E, Karal Y, Ekici A, Gündoğdu E
Childs Nerv Syst 2022 Feb;38(2):421-428. Epub 2021 Oct 29 doi: 10.1007/s00381-021-05402-6. PMID: 34713346
Low molecular weight heparin therapy in pediatric otogenic sigmoid sinus thrombosis: a safe treatment option?
Ropposch T, Nemetz U, Braun EM, Lackner A, Walch C
Int J Pediatr Otorhinolaryngol 2012 Jul;76(7):1023-6. Epub 2012 Apr 20 doi: 10.1016/j.ijporl.2012.03.024. PMID: 22521337

Recent clinical studies

Etiology

Pathophysiology, diagnosis and management of cerebral venous thrombosis: A comprehensive review.
Ranjan R, Ken-Dror G, Sharma P
Medicine (Baltimore) 2023 Dec 1;102(48):e36366. doi: 10.1097/MD.0000000000036366. PMID: 38050259Free PMC Article
Cerebral Venous Thrombosis: A Comprehensive Review.
Idiculla PS, Gurala D, Palanisamy M, Vijayakumar R, Dhandapani S, Nagarajan E
Eur Neurol 2020;83(4):369-379. Epub 2020 Sep 2 doi: 10.1159/000509802. PMID: 32877892
Cerebral venous sinus thrombosis.
Capecchi M, Abbattista M, Martinelli I
J Thromb Haemost 2018 Oct;16(10):1918-1931. Epub 2018 Jul 11 doi: 10.1111/jth.14210. PMID: 29923367
Thrombosis of the cerebral veins and sinuses.
Stam J
N Engl J Med 2005 Apr 28;352(17):1791-8. doi: 10.1056/NEJMra042354. PMID: 15858188
Prognosis of cerebral vein and dural sinus thrombosis: results of the International Study on Cerebral Vein and Dural Sinus Thrombosis (ISCVT).
Ferro JM, Canhão P, Stam J, Bousser MG, Barinagarrementeria F; ISCVT Investigators
Stroke 2004 Mar;35(3):664-70. Epub 2004 Feb 19 doi: 10.1161/01.STR.0000117571.76197.26. PMID: 14976332

Diagnosis

Cerebral Venous Thrombosis.
Ropper AH, Klein JP
N Engl J Med 2021 Jul 1;385(1):59-64. doi: 10.1056/NEJMra2106545. PMID: 34192432
Septic cavernous sinus thrombosis: A review.
Caranfa JT, Yoon MK
Surv Ophthalmol 2021 Nov-Dec;66(6):1021-1030. Epub 2021 Apr 5 doi: 10.1016/j.survophthal.2021.03.009. PMID: 33831391
Cerebral Venous Thrombosis: A Comprehensive Review.
Idiculla PS, Gurala D, Palanisamy M, Vijayakumar R, Dhandapani S, Nagarajan E
Eur Neurol 2020;83(4):369-379. Epub 2020 Sep 2 doi: 10.1159/000509802. PMID: 32877892
Cerebral venous sinus thrombosis.
Capecchi M, Abbattista M, Martinelli I
J Thromb Haemost 2018 Oct;16(10):1918-1931. Epub 2018 Jul 11 doi: 10.1111/jth.14210. PMID: 29923367
Thrombosis of the cerebral veins and sinuses.
Stam J
N Engl J Med 2005 Apr 28;352(17):1791-8. doi: 10.1056/NEJMra042354. PMID: 15858188

Therapy

Cerebral Venous Thrombosis.
Ropper AH, Klein JP
N Engl J Med 2021 Jul 1;385(1):59-64. doi: 10.1056/NEJMra2106545. PMID: 34192432
Septic cavernous sinus thrombosis: A review.
Caranfa JT, Yoon MK
Surv Ophthalmol 2021 Nov-Dec;66(6):1021-1030. Epub 2021 Apr 5 doi: 10.1016/j.survophthal.2021.03.009. PMID: 33831391
Neonatal cerebral sinovenous thrombosis.
Ramenghi LA, Cardiello V, Rossi A
Handb Clin Neurol 2019;162:267-280. doi: 10.1016/B978-0-444-64029-1.00012-6. PMID: 31324314
Cerebral venous sinus thrombosis.
Capecchi M, Abbattista M, Martinelli I
J Thromb Haemost 2018 Oct;16(10):1918-1931. Epub 2018 Jul 11 doi: 10.1111/jth.14210. PMID: 29923367
Thrombosis of the cerebral veins and sinuses.
Stam J
N Engl J Med 2005 Apr 28;352(17):1791-8. doi: 10.1056/NEJMra042354. PMID: 15858188

Prognosis

Diagnosis and Management of Cerebral Venous Thrombosis: A Scientific Statement From the American Heart Association.
Saposnik G, Bushnell C, Coutinho JM, Field TS, Furie KL, Galadanci N, Kam W, Kirkham FC, McNair ND, Singhal AB, Thijs V, Yang VXD; American Heart Association Stroke Council; Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation; Council on Cardiovascular and Stroke Nursing; and Council on Hypertension
Stroke 2024 Mar;55(3):e77-e90. Epub 2024 Jan 29 doi: 10.1161/STR.0000000000000456. PMID: 38284265
Cerebral Venous Thrombosis.
Ropper AH, Klein JP
N Engl J Med 2021 Jul 1;385(1):59-64. doi: 10.1056/NEJMra2106545. PMID: 34192432
Cerebral venous sinus thrombosis.
Capecchi M, Abbattista M, Martinelli I
J Thromb Haemost 2018 Oct;16(10):1918-1931. Epub 2018 Jul 11 doi: 10.1111/jth.14210. PMID: 29923367
Cerebral Sinus Thrombosis.
Agrawal K, Burger K, Rothrock JF
Headache 2016 Sep;56(8):1380-9. Epub 2016 Jun 28 doi: 10.1111/head.12873. PMID: 27350588
Prognosis of cerebral vein and dural sinus thrombosis: results of the International Study on Cerebral Vein and Dural Sinus Thrombosis (ISCVT).
Ferro JM, Canhão P, Stam J, Bousser MG, Barinagarrementeria F; ISCVT Investigators
Stroke 2004 Mar;35(3):664-70. Epub 2004 Feb 19 doi: 10.1161/01.STR.0000117571.76197.26. PMID: 14976332

Clinical prediction guides

COVID-19 vaccines and adverse events of special interest: A multinational Global Vaccine Data Network (GVDN) cohort study of 99 million vaccinated individuals.
Faksova K, Walsh D, Jiang Y, Griffin J, Phillips A, Gentile A, Kwong JC, Macartney K, Naus M, Grange Z, Escolano S, Sepulveda G, Shetty A, Pillsbury A, Sullivan C, Naveed Z, Janjua NZ, Giglio N, Perälä J, Nasreen S, Gidding H, Hovi P, Vo T, Cui F, Deng L, Cullen L, Artama M, Lu H, Clothier HJ, Batty K, Paynter J, Petousis-Harris H, Buttery J, Black S, Hviid A
Vaccine 2024 Apr 2;42(9):2200-2211. Epub 2024 Feb 12 doi: 10.1016/j.vaccine.2024.01.100. PMID: 38350768
Diagnosis and Management of Cerebral Venous Thrombosis: A Scientific Statement From the American Heart Association.
Saposnik G, Bushnell C, Coutinho JM, Field TS, Furie KL, Galadanci N, Kam W, Kirkham FC, McNair ND, Singhal AB, Thijs V, Yang VXD; American Heart Association Stroke Council; Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation; Council on Cardiovascular and Stroke Nursing; and Council on Hypertension
Stroke 2024 Mar;55(3):e77-e90. Epub 2024 Jan 29 doi: 10.1161/STR.0000000000000456. PMID: 38284265
Labbé vein thrombosis.
Boukobza M, Crassard I, Bousser MG, Chabriat H
Neuroradiology 2020 Aug;62(8):935-945. Epub 2020 Apr 13 doi: 10.1007/s00234-020-02396-x. PMID: 32281029
Stroke in Women.
Christensen H, Bushnell C
Continuum (Minneap Minn) 2020 Apr;26(2):363-385. doi: 10.1212/CON.0000000000000836. PMID: 32224757
Prognosis of cerebral vein and dural sinus thrombosis: results of the International Study on Cerebral Vein and Dural Sinus Thrombosis (ISCVT).
Ferro JM, Canhão P, Stam J, Bousser MG, Barinagarrementeria F; ISCVT Investigators
Stroke 2004 Mar;35(3):664-70. Epub 2004 Feb 19 doi: 10.1161/01.STR.0000117571.76197.26. PMID: 14976332

Recent systematic reviews

Cerebral Venous Sinus Thrombosis in Closed Head Injury: Systematic Review and Meta-analysis.
Alghamdi SR, Cho A, Lam J, Al-Saadi T
J Clin Neurosci 2022 Apr;98:254-260. Epub 2022 Mar 2 doi: 10.1016/j.jocn.2022.01.027. PMID: 35247707
Cerebral Venous Sinus Thrombosis Following COVID-19 Vaccination: A Systematic Review.
Jaiswal V, Nepal G, Dijamco P, Ishak A, Dagar M, Sarfraz Z, Shama N, Sarfraz A, Lnu K, Mitra S, Agarwala P, Naz S, Song D, Jaiswal A
J Prim Care Community Health 2022 Jan-Dec;13:21501319221074450. doi: 10.1177/21501319221074450. PMID: 35142234Free PMC Article
Vaccine-induced immune thrombotic thrombocytopenia and cerebral venous sinus thrombosis post COVID-19 vaccination; a systematic review.
Sharifian-Dorche M, Bahmanyar M, Sharifian-Dorche A, Mohammadi P, Nomovi M, Mowla A
J Neurol Sci 2021 Sep 15;428:117607. Epub 2021 Aug 3 doi: 10.1016/j.jns.2021.117607. PMID: 34365148Free PMC Article
Cerebral venous sinus thrombosis in pregnancy and puerperium: A pooled, systematic review.
Kashkoush AI, Ma H, Agarwal N, Panczykowski D, Tonetti D, Weiner GM, Ares W, Kenmuir C, Jadhav A, Jovin T, Jankowitz BT, Gross BA
J Clin Neurosci 2017 May;39:9-15. Epub 2017 Mar 6 doi: 10.1016/j.jocn.2017.02.046. PMID: 28274514
Cerebral Sinus Thrombosis.
Agrawal K, Burger K, Rothrock JF
Headache 2016 Sep;56(8):1380-9. Epub 2016 Jun 28 doi: 10.1111/head.12873. PMID: 27350588

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