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Eccrine mixed tumor of skin

MedGen UID:
91074
•Concept ID:
C0346026
•
Neoplastic Process
Synonyms: Benign Mixed Tumor of Skin; benign mixed tumor of skin; Benign Mixed Tumor of Skin (Chondroid Syringoma); benign mixed tumor of skin (chondroid syringoma); Benign Mixed Tumor of the Skin; benign mixed tumor of the skin; Benign Mixed Tumor of the Skin (Chondroid Syringoma); benign mixed tumor of the skin (chondroid syringoma); benign mixed tumour of skin; benign mixed tumour of skin (chondroid syringoma); benign mixed tumour of the skin; benign mixed tumour of the skin (chondroid syringoma); Chondroid Syringoma; chondroid syringoma; Eccrine mixed tumor; eccrine mixed tumor; eccrine mixed tumor (morphologic abnormality); eccrine mixed tumor of skin; eccrine mixed tumour; eccrine mixed tumour (morphologic abnormality); eccrine sweat gland mixed neoplasm; mixed eccrine neoplasm of the skin; Mixed tumor of skin; Mixed Tumor of the Skin (Chondroid Syringoma); mixed tumor of the skin (chondroid syringoma); mixed tumour of the skin (chondroid syringoma)
SNOMED CT: Eccrine mixed tumor (400144002); Eccrine mixed tumor of skin (254720009); Mixed tumor of skin (254720009); Eccrine mixed tumor (254720009)
 
Monarch Initiative: MONDO:0002200

Definition

A rare, benign, slow-growing and painless neoplasm of sweat glands. It usually arises in the head and neck. It is characterized by the presence of a mesenchymal chondroid stroma, fibrosis, and epithelial structures. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEccrine mixed tumor of skin

Recent clinical studies

Etiology

SOX10-Internal Tandem Duplications and PLAG1 or HMGA2 Fusions Segregate Eccrine-Type and Apocrine-Type Cutaneous Mixed Tumors.
Macagno N, Kervarrec T, Thanguturi S, Sohier P, Pissaloux D, Mescam L, Jullie ML, Frouin E, Osio A, Faisant M, Le Loarer F, Cribier B, Calonje E, Luna EVE, Massi D, Goto K, Nishida H, Paindavoine S, Houlier A, Tantot J, Benzerdjeb N, Tirode F, De la Fouchardière A, Battistella M
Mod Pathol 2024 Mar;37(3):100430. Epub 2024 Jan 23 doi: 10.1016/j.modpat.2024.100430. PMID: 38266920
A Case of a Malignant Cutaneous Mixed Tumor (Chondroid Syringoma) of the Scapula Treated With Staged Margin-Controlled Excision.
Lal K, Morrell TJ, Cunningham M, OʼDonnell P, Levin NA, Cornejo KM
Am J Dermatopathol 2018 Sep;40(9):679-681. doi: 10.1097/DAD.0000000000001131. PMID: 29533281
Paediatric cutaneous adnexal tumours: a study of 559 cases.
Ireland AM, Harvey NT, Berry BD, Wood BA
Pathology 2017 Jan;49(1):50-54. Epub 2016 Nov 30 doi: 10.1016/j.pathol.2016.10.003. PMID: 27914683
Cutaneous apocrine mixed tumor with intravascular tumor deposits: a diagnostic pitfall.
Kazakov DV, Kacerovska D, Skalova A, Zelger B, Schaller J, Shelekhova K, Michal M
Am J Dermatopathol 2011 Dec;33(8):775-9. doi: 10.1097/DAD.0b013e31820b7b9c. PMID: 21785330
Chondroid syringoma. Cytokeratin 20 immunolocalization of Merkel cells and reappraisal of apocrine folliculo-sebaceous differentiation.
Salama ME, Azam M, Ma CK, Ormsby A, Zarbo RJ, Amin MB, Lee MW
Arch Pathol Lab Med 2004 Sep;128(9):986-90. doi: 10.5858/2004-128-986-CS. PMID: 15335266

Diagnosis

Mixed Eccrine Cutaneous Tumor with Folliculo-Sebaceous Differentiation: Case Report and Literature Review.
Kisova D, Dikov T, Ivanova V, Stoyanov H, Yordanova G
Medicina (Kaunas) 2023 Aug 16;59(8) doi: 10.3390/medicina59081465. PMID: 37629755Free PMC Article
Giant Mixed Tumor of the Skin Affecting the Hemiface.
Sung KY, Lee SK, Jeong YJ, Lee SY
J Craniofac Surg 2020 Oct;31(7):e671-e673. doi: 10.1097/SCS.0000000000006510. PMID: 32516219
Differential Expression of PLAG1 in Apocrine and Eccrine Cutaneous Mixed Tumors: Evidence for Distinct Molecular Pathogenesis.
Russell-Goldman E, Dubuc A, Hanna J
Am J Dermatopathol 2020 Apr;42(4):251-257. doi: 10.1097/DAD.0000000000001393. PMID: 30839344
Dermoscopy of Adnexal Tumors.
Zaballos P, Gómez-Martín I, Martin JM, Bañuls J
Dermatol Clin 2018 Oct;36(4):397-412. Epub 2018 Aug 16 doi: 10.1016/j.det.2018.05.007. PMID: 30201149
Cutaneous mixed tumor, eccrine variant: a clinicopathologic and immunohistochemical study of 50 cases, with emphasis on unusual histopathologic features.
Kazakov DV, Kacerovska D, Hantschke M, Zelger B, Kutzner H, Requena L, Grayson W, Bisceglia M, Schaller J, Kempf W, Denisjuk N, Michal M
Am J Dermatopathol 2011 Aug;33(6):557-68. doi: 10.1097/DAD.0b013e318206c1a3. PMID: 21697702

Therapy

SOX10 immunohistochemistry in sweat ductal/glandular neoplasms.
Cassarino DS, Su A, Robbins BA, Altree-Tacha D, Ra S
J Cutan Pathol 2017 Jun;44(6):544-547. Epub 2017 Apr 20 doi: 10.1111/cup.12939. PMID: 28343365

Prognosis

Incidence and trends of cutaneous adnexal tumors in the United States in 2000-2018: A population-based study.
Gibbs DC, Yeung H, Blalock TW
J Am Acad Dermatol 2023 Jan;88(1):226-228. Epub 2022 May 4 doi: 10.1016/j.jaad.2022.04.052. PMID: 35525505Free PMC Article
Cutaneous apocrine mixed tumor with intravascular tumor deposits: a diagnostic pitfall.
Kazakov DV, Kacerovska D, Skalova A, Zelger B, Schaller J, Shelekhova K, Michal M
Am J Dermatopathol 2011 Dec;33(8):775-9. doi: 10.1097/DAD.0b013e31820b7b9c. PMID: 21785330
Pleomorphic adenoma in the auricle.
Yim YM, Yoon JW, Seo JW, Kwon H, Jung SN
J Craniofac Surg 2009 May;20(3):951-2. doi: 10.1097/SCS.0b013e3181a14bdf. PMID: 19461339
Expression of the peripheral benzodiazepine receptor is decreased in skin cancers in comparison with normal skin.
Morgan J, Oseroff AR, Cheney RT
Br J Dermatol 2004 Oct;151(4):846-56. doi: 10.1111/j.1365-2133.2004.06198.x. PMID: 15491426
Primary metaplastic carcinoma (carcinosarcoma) of the skin. A clinicopathologic study of four cases and review of the literature.
Patel NK, McKee PH, Smith NP, Fletcher CD
Am J Dermatopathol 1997 Aug;19(4):363-72. doi: 10.1097/00000372-199708000-00008. PMID: 9261471

Clinical prediction guides

SOX10-Internal Tandem Duplications and PLAG1 or HMGA2 Fusions Segregate Eccrine-Type and Apocrine-Type Cutaneous Mixed Tumors.
Macagno N, Kervarrec T, Thanguturi S, Sohier P, Pissaloux D, Mescam L, Jullie ML, Frouin E, Osio A, Faisant M, Le Loarer F, Cribier B, Calonje E, Luna EVE, Massi D, Goto K, Nishida H, Paindavoine S, Houlier A, Tantot J, Benzerdjeb N, Tirode F, De la Fouchardière A, Battistella M
Mod Pathol 2024 Mar;37(3):100430. Epub 2024 Jan 23 doi: 10.1016/j.modpat.2024.100430. PMID: 38266920
Dermoscopy of Adnexal Tumors.
Zaballos P, Gómez-Martín I, Martin JM, Bañuls J
Dermatol Clin 2018 Oct;36(4):397-412. Epub 2018 Aug 16 doi: 10.1016/j.det.2018.05.007. PMID: 30201149
The role of DOG1 immunohistochemistry in dermatopathology.
Goto K
J Cutan Pathol 2016 Nov;43(11):974-983. Epub 2016 Sep 5 doi: 10.1111/cup.12787. PMID: 27506854
Cutaneous apocrine mixed tumor with intravascular tumor deposits: a diagnostic pitfall.
Kazakov DV, Kacerovska D, Skalova A, Zelger B, Schaller J, Shelekhova K, Michal M
Am J Dermatopathol 2011 Dec;33(8):775-9. doi: 10.1097/DAD.0b013e31820b7b9c. PMID: 21785330
Immunohistochemical evaluation of tenascin in benign eccrine gland tumors: comparison with laminin and fibronectin.
Mori M, Shrestha P, Takagi H, Ogata K, Takai Y
J Dermatol Sci 1995 Mar;9(2):123-8. doi: 10.1016/0923-1811(94)00369-p. PMID: 7539630

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