U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Metastatic Malignant Neoplasm in the Bone Marrow

MedGen UID:
91111
•Concept ID:
C0346979
•
Neoplastic Process
Synonyms: Cancer metastatic to bone marrow; Metastases to the Bone Marrow; Metastasis to bone marrow; Metastasis to the Bone Marrow; Metastatic malignant neoplasm of bone marrow; Metastatic malignant neoplasm to bone marrow; Metastatic Malignant Neoplasm to the Bone Marrow; Metastatic Neoplasm to the Bone Marrow; Metastatic Tumor to the Bone Marrow; Secondary malignant neoplasm of bone marrow
SNOMED CT: Secondary malignant neoplasm of bone marrow (94217008); Metastatic malignant neoplasm to bone marrow (94217008); Cancer metastatic to bone marrow (94217008); Metastatic malignant neoplasm of bone marrow (94217008); Metastasis to bone marrow (94217008)

Definition

The spread of a malignant neoplasm from its original site of growth to the bone marrow. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Malignant Neoplasm in the Bone Marrow

Professional guidelines

PubMed

2022 international clinical practice guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer, including patients with COVID-19.
Farge D, Frere C, Connors JM, Khorana AA, Kakkar A, Ay C, Muñoz A, Brenner B, Prata PH, Brilhante D, Antic D, Casais P, Guillermo Esposito MC, Ikezoe T, Abutalib SA, Meillon-García LA, Bounameaux H, Pabinger I, Douketis J; International Initiative on Thrombosis and Cancer (ITAC) advisory panel
Lancet Oncol 2022 Jul;23(7):e334-e347. doi: 10.1016/S1470-2045(22)00160-7. PMID: 35772465Free PMC Article
Diagnosis and management of Aspergillus diseases: executive summary of the 2017 ESCMID-ECMM-ERS guideline.
Ullmann AJ, Aguado JM, Arikan-Akdagli S, Denning DW, Groll AH, Lagrou K, Lass-Flörl C, Lewis RE, Munoz P, Verweij PE, Warris A, Ader F, Akova M, Arendrup MC, Barnes RA, Beigelman-Aubry C, Blot S, Bouza E, Brüggemann RJM, Buchheidt D, Cadranel J, Castagnola E, Chakrabarti A, Cuenca-Estrella M, Dimopoulos G, Fortun J, Gangneux JP, Garbino J, Heinz WJ, Herbrecht R, Heussel CP, Kibbler CC, Klimko N, Kullberg BJ, Lange C, Lehrnbecher T, Löffler J, Lortholary O, Maertens J, Marchetti O, Meis JF, Pagano L, Ribaud P, Richardson M, Roilides E, Ruhnke M, Sanguinetti M, Sheppard DC, Sinkó J, Skiada A, Vehreschild MJGT, Viscoli C, Cornely OA
Clin Microbiol Infect 2018 May;24 Suppl 1:e1-e38. Epub 2018 Mar 12 doi: 10.1016/j.cmi.2018.01.002. PMID: 29544767
Leukemia: an overview for primary care.
Davis AS, Viera AJ, Mead MD
Am Fam Physician 2014 May 1;89(9):731-8. PMID: 24784336

Recent clinical studies

Etiology

Tumor dormancy in bone.
Mayhew V, Omokehinde T, Johnson RW
Cancer Rep (Hoboken) 2020 Feb;3(1):e1156. Epub 2019 Jan 29 doi: 10.1002/cnr2.1156. PMID: 32632400Free PMC Article
MDS overlap disorders and diagnostic boundaries.
Tanaka TN, Bejar R
Blood 2019 Mar 7;133(10):1086-1095. Epub 2019 Jan 22 doi: 10.1182/blood-2018-10-844670. PMID: 30670443
Hypoxia and Bone Metastatic Disease.
Johnson RW, Sowder ME, Giaccia AJ
Curr Osteoporos Rep 2017 Aug;15(4):231-238. doi: 10.1007/s11914-017-0378-8. PMID: 28597139Free PMC Article
Haemophagocytic syndrome after intravesical bacille Calmette-Guérin instillation.
Misra S, Gupta A, Symes A, Duncan J
Scand J Urol 2014 Jun;48(3):328-30. Epub 2013 Sep 27 doi: 10.3109/21681805.2013.836724. PMID: 24070063
Managing hematologic toxicities in the oncology patient.
Montoya L
J Infus Nurs 2007 May-Jun;30(3):168-72. doi: 10.1097/01.NAN.0000270676.59180.c3. PMID: 17505218

Diagnosis

Myeloid-like tumor hybrid cells in bone marrow promote progression of prostate cancer bone metastasis.
Ye X, Huang X, Fu X, Zhang X, Lin R, Zhang W, Zhang J, Lu Y
J Hematol Oncol 2023 May 3;16(1):46. doi: 10.1186/s13045-023-01442-4. PMID: 37138326Free PMC Article
Occult recurrent breast cancer masquerading as thrombotic thrombocytopenic purpura.
Wills-Sanin B, George JN, Boiocchi L, Soff GA, Mones JV
Am J Hematol 2023 May;98(5):830-832. Epub 2022 Oct 28 doi: 10.1002/ajh.26761. PMID: 36222494
Metastatic melanoma mimicking acute leukaemia.
Kaliks RA, Silveira PA, Osawa A, Campregher PV, Bacal NS, Velloso ED
Br J Haematol 2014 Apr;165(1):1. Epub 2013 Nov 25 doi: 10.1111/bjh.12669. PMID: 24266414
Metastatic neuroendocrine cells.
Hsia CC, Chin-Yee IH
Blood 2011 Sep 1;118(9):2387. doi: 10.1182/blood-2010-10-310094. PMID: 21998848
Extrathoracic PET/CT findings in thoracic malignancies.
Marom EM, Bruzzi JF, Truong MT
J Thorac Imaging 2006 May;21(2):154-66. doi: 10.1097/00005382-200605000-00007. PMID: 16770232

Therapy

New Drug Protects Against Myelosuppression Secondary to Lung Cancer Chemotherapy.
Aschenbrenner DS
Am J Nurs 2021 Jun 1;121(6):21. doi: 10.1097/01.NAJ.0000753640.11029.39. PMID: 34009159
MDS overlap disorders and diagnostic boundaries.
Tanaka TN, Bejar R
Blood 2019 Mar 7;133(10):1086-1095. Epub 2019 Jan 22 doi: 10.1182/blood-2018-10-844670. PMID: 30670443
Haemophagocytic syndrome after intravesical bacille Calmette-Guérin instillation.
Misra S, Gupta A, Symes A, Duncan J
Scand J Urol 2014 Jun;48(3):328-30. Epub 2013 Sep 27 doi: 10.3109/21681805.2013.836724. PMID: 24070063
Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype.
Falini B, Mecucci C, Tiacci E, Alcalay M, Rosati R, Pasqualucci L, La Starza R, Diverio D, Colombo E, Santucci A, Bigerna B, Pacini R, Pucciarini A, Liso A, Vignetti M, Fazi P, Meani N, Pettirossi V, Saglio G, Mandelli F, Lo-Coco F, Pelicci PG, Martelli MF; GIMEMA Acute Leukemia Working Party
N Engl J Med 2005 Jan 20;352(3):254-66. doi: 10.1056/NEJMoa041974. PMID: 15659725
Myelofibrosis in neuroblastoma.
Labotka RJ, Morgan ER
Med Pediatr Oncol 1982;10(1):21-6. doi: 10.1002/mpo.2950100105. PMID: 7062895

Prognosis

Single-cell analyses of metastatic bone marrow in human neuroblastoma reveals microenvironmental remodeling and metastatic signature.
Mei S, Alchahin AM, Embaie BT, Gavriliuc IM, Verhoeven BM, Zhao T, Li X, Jeffries NE, Pepich A, Sarkar H, Olsen TK, Wickström M, Stenman J, Reina-Bedoya O, Kharchenko PV, Saylor PJ, Johnsen JI, Sykes DB, Kogner P, Baryawno N
JCI Insight 2024 Feb 15;9(6) doi: 10.1172/jci.insight.173337. PMID: 38358826Free PMC Article
Mammary tumour cells remodel the bone marrow vascular microenvironment to support metastasis.
Yip RKH, Rimes JS, Capaldo BD, Vaillant F, Mouchemore KA, Pal B, Chen Y, Surgenor E, Murphy AJ, Anderson RL, Smyth GK, Lindeman GJ, Hawkins ED, Visvader JE
Nat Commun 2021 Nov 26;12(1):6920. doi: 10.1038/s41467-021-26556-6. PMID: 34836954Free PMC Article
Metastatic neuroendocrine cells.
Hsia CC, Chin-Yee IH
Blood 2011 Sep 1;118(9):2387. doi: 10.1182/blood-2010-10-310094. PMID: 21998848
Secondary leukemia after severe aplastic anemia.
Tichelli A, Gratwohl A, Würsch A, Nissen C, Speck B
Blut 1988 Feb;56(2):79-81. doi: 10.1007/BF00633468. PMID: 3422575
Mantle-zone lymphoma: a follicular variant of intermediate lymphocytic lymphoma.
Weisenburger DD, Kim H, Rappaport H
Cancer 1982 Apr 1;49(7):1429-38. doi: 10.1002/1097-0142(19820401)49:7<1429::aid-cncr2820490720>3.0.co;2-5. PMID: 6895860

Clinical prediction guides

Single-cell analyses of metastatic bone marrow in human neuroblastoma reveals microenvironmental remodeling and metastatic signature.
Mei S, Alchahin AM, Embaie BT, Gavriliuc IM, Verhoeven BM, Zhao T, Li X, Jeffries NE, Pepich A, Sarkar H, Olsen TK, Wickström M, Stenman J, Reina-Bedoya O, Kharchenko PV, Saylor PJ, Johnsen JI, Sykes DB, Kogner P, Baryawno N
JCI Insight 2024 Feb 15;9(6) doi: 10.1172/jci.insight.173337. PMID: 38358826Free PMC Article
Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classification.
Cheson BD, Fisher RI, Barrington SF, Cavalli F, Schwartz LH, Zucca E, Lister TA; Alliance, Australasian Leukaemia and Lymphoma Group; Eastern Cooperative Oncology Group; European Mantle Cell Lymphoma Consortium; Italian Lymphoma Foundation; European Organisation for Research; Treatment of Cancer/Dutch Hemato-Oncology Group; Grupo Español de Médula Ósea; German High-Grade Lymphoma Study Group; German Hodgkin's Study Group; Japanese Lymphorra Study Group; Lymphoma Study Association; NCIC Clinical Trials Group; Nordic Lymphoma Study Group; Southwest Oncology Group; United Kingdom National Cancer Research Institute
J Clin Oncol 2014 Sep 20;32(27):3059-68. doi: 10.1200/JCO.2013.54.8800. PMID: 25113753Free PMC Article
Bone marrow and the control of immunity.
Zhao E, Xu H, Wang L, Kryczek I, Wu K, Hu Y, Wang G, Zou W
Cell Mol Immunol 2012 Jan;9(1):11-9. Epub 2011 Oct 24 doi: 10.1038/cmi.2011.47. PMID: 22020068Free PMC Article
Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype.
Falini B, Mecucci C, Tiacci E, Alcalay M, Rosati R, Pasqualucci L, La Starza R, Diverio D, Colombo E, Santucci A, Bigerna B, Pacini R, Pucciarini A, Liso A, Vignetti M, Fazi P, Meani N, Pettirossi V, Saglio G, Mandelli F, Lo-Coco F, Pelicci PG, Martelli MF; GIMEMA Acute Leukemia Working Party
N Engl J Med 2005 Jan 20;352(3):254-66. doi: 10.1056/NEJMoa041974. PMID: 15659725
Secondary leukemia after severe aplastic anemia.
Tichelli A, Gratwohl A, Würsch A, Nissen C, Speck B
Blut 1988 Feb;56(2):79-81. doi: 10.1007/BF00633468. PMID: 3422575

Recent systematic reviews

Bone marrow metastases: a systematic review of a neglected involvement in malignant melanoma.
Paolino G, Carugno A, Rongioletti F, Ponzoni M, Russo V, Sena P, Ardigò M, Costanzo A, Mercuri SR, Valenti M
Melanoma Res 2024 Feb 1;34(1):31-37. Epub 2023 Nov 8 doi: 10.1097/CMR.0000000000000942. PMID: 37939076
Efficacy and safety of immunosuppressive agents for adults with lupus nephritis: a systematic review and network meta-analysis.
Jiang N, Jin S, Yu C, Zhao J, Wang Q, Tian X, Li M, Zeng X
Front Immunol 2023;14:1232244. Epub 2023 Oct 13 doi: 10.3389/fimmu.2023.1232244. PMID: 37901212Free PMC Article
The Role of Cytokines in the Metastasis of Solid Tumors to the Spine: Systematic Review.
Łabędź W, Przybyla A, Zimna A, Dąbrowski M, Kubaszewski Ł
Int J Mol Sci 2023 Feb 14;24(4) doi: 10.3390/ijms24043785. PMID: 36835198Free PMC Article
A Systematic Review and Meta-analytic Evaluation of Moral Distress in Oncology Nursing.
Eche IJ, Phillips CS, Alcindor N, Mazzola E
Cancer Nurs 2023 Mar-Apr 01;46(2):128-142. Epub 2022 Mar 14 doi: 10.1097/NCC.0000000000001075. PMID: 35283474
Pelvic bone marrow sparing radiotherapy for cervical cancer: A systematic review and meta-analysis.
Zhou P, Zhang Y, Luo S, Zhang S
Radiother Oncol 2021 Dec;165:103-118. Epub 2021 Oct 27 doi: 10.1016/j.radonc.2021.10.015. PMID: 34718055

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...