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Metastatic Malignant Neoplasm in the Orbit

MedGen UID:
91116
•Concept ID:
C0347020
•
Neoplastic Process
Synonyms: Metastasis to orbit; Metastasis to the Orbit; Metastatic malignant neoplasm of orbit; Metastatic malignant neoplasm to orbit; Metastatic Malignant Neoplasm to the Orbit; Metastatic Neoplasm to the Orbit; Metastatic Tumor to the Orbit; Secondary malignant neoplasm of orbit; Secondary malignant neoplasm of orbit proper; Secondary tumor of orbit
SNOMED CT: Secondary tumor of orbit (94453007); Metastasis to orbit (94453007); Secondary malignant neoplasm of orbit (94453007); Metastatic malignant neoplasm to orbit (94453007); Secondary malignant neoplasm of orbit proper (94453007); Metastatic malignant neoplasm of orbit (94453007)

Definition

A malignant neoplasm that has spread to the orbit from another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Malignant Neoplasm in the Orbit

Professional guidelines

PubMed

Management of non-hepatic distant metastases in neuroendocrine neoplasms.
Lacalle-González C, Estrella Santos A, Landaeta Kancev LC, Castellano VM, Macia Palafox E, Paniagua Ruíz A, Luna Tirado J, Martínez-Amores B, Martínez Dhier L, Lamarca A
Best Pract Res Clin Endocrinol Metab 2023 Sep;37(5):101784. Epub 2023 May 10 doi: 10.1016/j.beem.2023.101784. PMID: 37270333
Current opinions on diagnosis and treatment of adenoid cystic carcinoma.
Fang Y, Peng Z, Wang Y, Gao K, Liu Y, Fan R, Zhang H, Xie Z, Jiang W
Oral Oncol 2022 Jul;130:105945. Epub 2022 Jun 2 doi: 10.1016/j.oraloncology.2022.105945. PMID: 35662026
Clinical Management of Uveal and Conjunctival Melanoma.
Blum ES, Yang J, Komatsubara KM, Carvajal RD
Oncology (Williston Park) 2016 Jan;30(1):29-32, 34-43, 48. PMID: 26791842

Recent clinical studies

Etiology

A review of solitary fibrous tumours of the orbit and ocular adnexa.
René C, Scollo P, O'Donovan D
Eye (Lond) 2023 Apr;37(5):858-865. Epub 2022 Jul 13 doi: 10.1038/s41433-022-02160-w. PMID: 35831617Free PMC Article
Ocular involvement in metastatic and systemic malignancies is not rare.
Sthapit PR, Saiju R
Cancer Rep (Hoboken) 2021 Aug;4(4):e1347. Epub 2021 Feb 3 doi: 10.1002/cnr2.1347. PMID: 33535273Free PMC Article
Thyroid and Eye: Where They Meet in Clinical Practice.
El-Eshmawy MM, Shahin M
Endocr Metab Immune Disord Drug Targets 2020;20(1):39-49. doi: 10.2174/1871530319666190618120107. PMID: 31237221
Overview of benign and malignant lacrimal gland tumors.
Gündüz AK, Yeşiltaş YS, Shields CL
Curr Opin Ophthalmol 2018 Sep;29(5):458-468. doi: 10.1097/ICU.0000000000000515. PMID: 30028745
Orbital rhabdomyosarcoma.
Karcioglu ZA, Hadjistilianou D, Rozans M, DeFrancesco S
Cancer Control 2004 Sep-Oct;11(5):328-33. doi: 10.1177/107327480401100507. PMID: 15377992

Diagnosis

A review of solitary fibrous tumours of the orbit and ocular adnexa.
René C, Scollo P, O'Donovan D
Eye (Lond) 2023 Apr;37(5):858-865. Epub 2022 Jul 13 doi: 10.1038/s41433-022-02160-w. PMID: 35831617Free PMC Article
Orbital Ependymoma.
Tsimchi IM, Malik AI, Takashima M, Lee AG
Ophthalmic Plast Reconstr Surg 2022 Mar-Apr 01;38(2):e51-e54. doi: 10.1097/IOP.0000000000002095. PMID: 35030150
Ocular involvement in metastatic and systemic malignancies is not rare.
Sthapit PR, Saiju R
Cancer Rep (Hoboken) 2021 Aug;4(4):e1347. Epub 2021 Feb 3 doi: 10.1002/cnr2.1347. PMID: 33535273Free PMC Article
Orbital tumors.
Weisman RA, Kikkawa D, Moe KS, Osguthorpe JD
Otolaryngol Clin North Am 2001 Dec;34(6):1157-74, ix-x. doi: 10.1016/s0030-6665(05)70372-8. PMID: 11728939
Neural orbital tumors.
Cantore WA
Curr Opin Ophthalmol 2000 Oct;11(5):367-71. doi: 10.1097/00055735-200010000-00014. PMID: 11148705

Therapy

Clinical features and prognosis of patients with metastatic ocular and orbital melanoma: A bi-institutional study.
Liu X, Yue H, Jiang S, Kong L, Xu Y, Chen Y, Wang C, Wang Y, Zhu X, Kong Y, Zhang X, Qian J, Luo Z
Cancer Med 2023 Aug;12(15):16163-16172. Epub 2023 Jul 6 doi: 10.1002/cam4.6273. PMID: 37409486Free PMC Article
Neuroblastoma: Essential genetic pathways and current therapeutic options.
Salemi F, Alam W, Hassani MS, Hashemi SZ, Jafari AA, Mirmoeeni SMS, Arbab M, Mortazavizadeh SMR, Khan H
Eur J Pharmacol 2022 Jul 5;926:175030. Epub 2022 May 20 doi: 10.1016/j.ejphar.2022.175030. PMID: 35605657
Thyroid and Eye: Where They Meet in Clinical Practice.
El-Eshmawy MM, Shahin M
Endocr Metab Immune Disord Drug Targets 2020;20(1):39-49. doi: 10.2174/1871530319666190618120107. PMID: 31237221
Sclerosing Lesions of the Orbit: A Review.
Lokdarshi G, Pushker N, Bajaj MS
Middle East Afr J Ophthalmol 2015 Oct-Dec;22(4):447-51. doi: 10.4103/0974-9233.167807. PMID: 26692715Free PMC Article
Orbital rhabdomyosarcoma.
Karcioglu ZA, Hadjistilianou D, Rozans M, DeFrancesco S
Cancer Control 2004 Sep-Oct;11(5):328-33. doi: 10.1177/107327480401100507. PMID: 15377992

Prognosis

A review of solitary fibrous tumours of the orbit and ocular adnexa.
René C, Scollo P, O'Donovan D
Eye (Lond) 2023 Apr;37(5):858-865. Epub 2022 Jul 13 doi: 10.1038/s41433-022-02160-w. PMID: 35831617Free PMC Article
Metastases of systemic malignancies to the orbit: a major review.
Wladis EJ, Lee KW, Nazeer T
Orbit 2021 Apr;40(2):93-97. Epub 2020 Apr 27 doi: 10.1080/01676830.2020.1759110. PMID: 32340504
Overview of benign and malignant lacrimal gland tumors.
Gündüz AK, Yeşiltaş YS, Shields CL
Curr Opin Ophthalmol 2018 Sep;29(5):458-468. doi: 10.1097/ICU.0000000000000515. PMID: 30028745
Lymphoproliferative Tumors of the Ocular Adnexa.
Verdijk RM
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):132-142. doi: 10.22608/APO.2016209. PMID: 28399341
Orbital rhabdomyosarcoma.
Karcioglu ZA, Hadjistilianou D, Rozans M, DeFrancesco S
Cancer Control 2004 Sep-Oct;11(5):328-33. doi: 10.1177/107327480401100507. PMID: 15377992

Clinical prediction guides

Lymph node metastasis in cancer progression: molecular mechanisms, clinical significance and therapeutic interventions.
Ji H, Hu C, Yang X, Liu Y, Ji G, Ge S, Wang X, Wang M
Signal Transduct Target Ther 2023 Sep 27;8(1):367. doi: 10.1038/s41392-023-01576-4. PMID: 37752146Free PMC Article
Cancers of the eye.
Maheshwari A, Finger PT
Cancer Metastasis Rev 2018 Dec;37(4):677-690. doi: 10.1007/s10555-018-9762-9. PMID: 30203109
Orbital Metastases: When to Suspect? When to biopsy?
Allen RC
Middle East Afr J Ophthalmol 2018 Apr-Jun;25(2):60-64. doi: 10.4103/meajo.MEAJO_93_18. PMID: 30122850Free PMC Article
Extranodal Diffuse Large B Cell Lymphoma: Molecular Features, Prognosis, and Risk of Central Nervous System Recurrence.
Ollila TA, Olszewski AJ
Curr Treat Options Oncol 2018 Jun 21;19(8):38. doi: 10.1007/s11864-018-0555-8. PMID: 29931605Free PMC Article
Retinoblastoma.
Aerts I, Lumbroso-Le Rouic L, Gauthier-Villars M, Brisse H, Doz F, Desjardins L
Orphanet J Rare Dis 2006 Aug 25;1:31. doi: 10.1186/1750-1172-1-31. PMID: 16934146Free PMC Article

Recent systematic reviews

Metastatic Meningioma of the Neck: A Case Report and Systematic Review.
Nguyen HCB, Mady LJ, Panara K, Andrianus S, Cooper K, Chen IH, Chalian AA, Brody RM
ORL J Otorhinolaryngol Relat Spec 2022;84(5):361-369. Epub 2022 Feb 3 doi: 10.1159/000521076. PMID: 35114675
The role of adjuvant systemic steroids in the management of periorbital cellulitis secondary to sinusitis: a systematic review and meta-analysis.
Mahalingam S, Luke L, Pundir J, Pundir V
Eur Arch Otorhinolaryngol 2021 Jul;278(7):2193-2201. Epub 2020 Aug 24 doi: 10.1007/s00405-020-06294-z. PMID: 32833055
Ophthalmic involvement of chronic lymphocytic leukemia: A systematic review of 123 cases.
Delestre F, Blanche P, Bouayed E, Bouscary D, Mouthon L, Brezin A, Le Jeunne C, Chaigne B
Surv Ophthalmol 2021 Jan-Feb;66(1):124-131. Epub 2020 May 11 doi: 10.1016/j.survophthal.2020.05.001. PMID: 32407752
High frequency of lobular breast cancer in distant metastases to the orbit.
Raap M, Antonopoulos W, Dämmrich M, Christgen H, Steinmann D, Länger F, Lehmann U, Kreipe H, Christgen M
Cancer Med 2015 Jan;4(1):104-11. Epub 2014 Oct 30 doi: 10.1002/cam4.331. PMID: 25355547Free PMC Article
Cutaneous malignant melanoma metastatic to the eye, lids, and orbit.
Rosenberg C, Finger PT
Surv Ophthalmol 2008 May-Jun;53(3):187-202. doi: 10.1016/j.survophthal.2008.02.003. PMID: 18501266

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