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Vulvar Small Cell Neuroendocrine Carcinoma

MedGen UID:
925532
•Concept ID:
C4288000
•
Neoplastic Process
Synonym: Vulvar Small Cell Carcinoma

Definition

A rare small cell neuroendocrine carcinoma that arises from the vulva. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVulvar Small Cell Neuroendocrine Carcinoma

Professional guidelines

PubMed

Vulvar cancer: initial management and systematic review of literature on currently applied treatment approaches.
Sznurkowski JJ
Eur J Cancer Care (Engl) 2016 Jul;25(4):638-46. Epub 2016 Feb 16 doi: 10.1111/ecc.12455. PMID: 26880231
ACR Appropriateness Criteria® management of locoregionally advanced squamous cell carcinoma of the vulva.
Expert Panel on Radiation Oncology-Gynecology, Kidd E, Moore D, Varia MA, Gaffney DK, Elshaikh MA, Erickson B, Jhingran A, Lee LJ, Mayr NA, Puthawala AA, Rao GG, Small W Jr, Wahl AO, Wolfson AH, Yashar CM, Yuh W, Cardenes HR
Am J Clin Oncol 2013 Aug;36(4):415-22. doi: 10.1097/COC.0b013e318295af1d. PMID: 23872794
The management of small-cell carcinomas of the gynecologic tract.
Cohen JG, Chan JK, Kapp DS
Curr Opin Oncol 2012 Sep;24(5):572-9. doi: 10.1097/CCO.0b013e3283565ed6. PMID: 22820410

Recent clinical studies

Etiology

Pediatric vulvar malignancies: rare but important to know.
Strickland AL, Fadare O
Semin Diagn Pathol 2021 Jan;38(1):99-109. Epub 2020 Sep 5 doi: 10.1053/j.semdp.2020.09.001. PMID: 32943238
Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: a report from the ESMO Precision Medicine Working Group.
Mosele F, Remon J, Mateo J, Westphalen CB, Barlesi F, Lolkema MP, Normanno N, Scarpa A, Robson M, Meric-Bernstam F, Wagle N, Stenzinger A, Bonastre J, Bayle A, Michiels S, Bièche I, Rouleau E, Jezdic S, Douillard JY, Reis-Filho JS, Dienstmann R, André F
Ann Oncol 2020 Nov;31(11):1491-1505. Epub 2020 Aug 24 doi: 10.1016/j.annonc.2020.07.014. PMID: 32853681
Small cell cancers of the female genital tract: Molecular and clinical aspects.
Patibandla JR, Fehniger JE, Levine DA, Jelinic P
Gynecol Oncol 2018 May;149(2):420-427. Epub 2018 Feb 17 doi: 10.1016/j.ygyno.2018.02.004. PMID: 29458976
Small cell carcinoma of the gynecologic tract: a multifaceted spectrum of lesions.
Atienza-Amores M, Guerini-Rocco E, Soslow RA, Park KJ, Weigelt B
Gynecol Oncol 2014 Aug;134(2):410-8. Epub 2014 May 27 doi: 10.1016/j.ygyno.2014.05.017. PMID: 24875120
Bowenoid papulosis.
Rogozinski TT, Janniger CK
Am Fam Physician 1988 Jul;38(1):161-4. PMID: 2839970

Diagnosis

Pediatric vulvar malignancies: rare but important to know.
Strickland AL, Fadare O
Semin Diagn Pathol 2021 Jan;38(1):99-109. Epub 2020 Sep 5 doi: 10.1053/j.semdp.2020.09.001. PMID: 32943238
Small cell cancers of the female genital tract: Molecular and clinical aspects.
Patibandla JR, Fehniger JE, Levine DA, Jelinic P
Gynecol Oncol 2018 May;149(2):420-427. Epub 2018 Feb 17 doi: 10.1016/j.ygyno.2018.02.004. PMID: 29458976
Small cell carcinoma of the gynecologic tract: a multifaceted spectrum of lesions.
Atienza-Amores M, Guerini-Rocco E, Soslow RA, Park KJ, Weigelt B
Gynecol Oncol 2014 Aug;134(2):410-8. Epub 2014 May 27 doi: 10.1016/j.ygyno.2014.05.017. PMID: 24875120
The management of small-cell carcinomas of the gynecologic tract.
Cohen JG, Chan JK, Kapp DS
Curr Opin Oncol 2012 Sep;24(5):572-9. doi: 10.1097/CCO.0b013e3283565ed6. PMID: 22820410
Recurrent vulvar cancer.
Salom EM, Penalver M
Curr Treat Options Oncol 2002 Apr;3(2):143-53. doi: 10.1007/s11864-002-0060-x. PMID: 12057077

Therapy

Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: a report from the ESMO Precision Medicine Working Group.
Mosele F, Remon J, Mateo J, Westphalen CB, Barlesi F, Lolkema MP, Normanno N, Scarpa A, Robson M, Meric-Bernstam F, Wagle N, Stenzinger A, Bonastre J, Bayle A, Michiels S, Bièche I, Rouleau E, Jezdic S, Douillard JY, Reis-Filho JS, Dienstmann R, André F
Ann Oncol 2020 Nov;31(11):1491-1505. Epub 2020 Aug 24 doi: 10.1016/j.annonc.2020.07.014. PMID: 32853681
Prevalence and type distribution of human papillomavirus in squamous cell carcinoma and intraepithelial neoplasia of the vulva.
Faber MT, Sand FL, Albieri V, Norrild B, Kjaer SK, Verdoodt F
Int J Cancer 2017 Sep 15;141(6):1161-1169. Epub 2017 Jun 21 doi: 10.1002/ijc.30821. PMID: 28577297
The management of small-cell carcinomas of the gynecologic tract.
Cohen JG, Chan JK, Kapp DS
Curr Opin Oncol 2012 Sep;24(5):572-9. doi: 10.1097/CCO.0b013e3283565ed6. PMID: 22820410
Small cell carcinoma of the female genital tract.
Crowder S, Tuller E
Semin Oncol 2007 Feb;34(1):57-63. doi: 10.1053/j.seminoncol.2006.10.028. PMID: 17270667
Recurrent vulvar cancer.
Salom EM, Penalver M
Curr Treat Options Oncol 2002 Apr;3(2):143-53. doi: 10.1007/s11864-002-0060-x. PMID: 12057077

Prognosis

Pediatric vulvar malignancies: rare but important to know.
Strickland AL, Fadare O
Semin Diagn Pathol 2021 Jan;38(1):99-109. Epub 2020 Sep 5 doi: 10.1053/j.semdp.2020.09.001. PMID: 32943238
Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: a report from the ESMO Precision Medicine Working Group.
Mosele F, Remon J, Mateo J, Westphalen CB, Barlesi F, Lolkema MP, Normanno N, Scarpa A, Robson M, Meric-Bernstam F, Wagle N, Stenzinger A, Bonastre J, Bayle A, Michiels S, Bièche I, Rouleau E, Jezdic S, Douillard JY, Reis-Filho JS, Dienstmann R, André F
Ann Oncol 2020 Nov;31(11):1491-1505. Epub 2020 Aug 24 doi: 10.1016/j.annonc.2020.07.014. PMID: 32853681
Small cell cancers of the female genital tract: Molecular and clinical aspects.
Patibandla JR, Fehniger JE, Levine DA, Jelinic P
Gynecol Oncol 2018 May;149(2):420-427. Epub 2018 Feb 17 doi: 10.1016/j.ygyno.2018.02.004. PMID: 29458976
Small cell carcinoma of the gynecologic tract: a multifaceted spectrum of lesions.
Atienza-Amores M, Guerini-Rocco E, Soslow RA, Park KJ, Weigelt B
Gynecol Oncol 2014 Aug;134(2):410-8. Epub 2014 May 27 doi: 10.1016/j.ygyno.2014.05.017. PMID: 24875120
The management of small-cell carcinomas of the gynecologic tract.
Cohen JG, Chan JK, Kapp DS
Curr Opin Oncol 2012 Sep;24(5):572-9. doi: 10.1097/CCO.0b013e3283565ed6. PMID: 22820410

Clinical prediction guides

High prevalence of p16 staining in malignant tumors.
De Wispelaere N, Rico SD, Bauer M, Luebke AM, Kluth M, Büscheck F, Hube-Magg C, Höflmayer D, Gorbokon N, Weidemann S, Möller K, Fraune C, Bernreuther C, Simon R, Kähler C, Menz A, Hinsch A, Jacobsen F, Lebok P, Clauditz T, Sauter G, Uhlig R, Wilczak W, Steurer S, Burandt E, Krech R, Dum D, Krech T, Marx A, Minner S
PLoS One 2022;17(7):e0262877. Epub 2022 Jul 21 doi: 10.1371/journal.pone.0262877. PMID: 35862385Free PMC Article
Molecular Landscape of Vulvar Squamous Cell Carcinoma.
Carreras-Dieguez N, Guerrero J, Rodrigo-Calvo MT, Ribera-Cortada I, Trias I, Jares P, López Del Campo R, Saco A, Munmany M, Marimon L, Ferrando M, Vega N, Del Pino M, Torné A, Ordi J, Rakislova N
Int J Mol Sci 2021 Jun 30;22(13) doi: 10.3390/ijms22137069. PMID: 34209172Free PMC Article
Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: a report from the ESMO Precision Medicine Working Group.
Mosele F, Remon J, Mateo J, Westphalen CB, Barlesi F, Lolkema MP, Normanno N, Scarpa A, Robson M, Meric-Bernstam F, Wagle N, Stenzinger A, Bonastre J, Bayle A, Michiels S, Bièche I, Rouleau E, Jezdic S, Douillard JY, Reis-Filho JS, Dienstmann R, André F
Ann Oncol 2020 Nov;31(11):1491-1505. Epub 2020 Aug 24 doi: 10.1016/j.annonc.2020.07.014. PMID: 32853681
Does HPV status influence survival after vulvar cancer?
Rasmussen CL, Sand FL, Hoffmann Frederiksen M, Kaae Andersen K, Kjaer SK
Int J Cancer 2018 Mar 15;142(6):1158-1165. Epub 2017 Nov 16 doi: 10.1002/ijc.31139. PMID: 29090456
Prevalence and type distribution of human papillomavirus in squamous cell carcinoma and intraepithelial neoplasia of the vulva.
Faber MT, Sand FL, Albieri V, Norrild B, Kjaer SK, Verdoodt F
Int J Cancer 2017 Sep 15;141(6):1161-1169. Epub 2017 Jun 21 doi: 10.1002/ijc.30821. PMID: 28577297

Recent systematic reviews

Potential targets for tumor-specific imaging of vulvar squamous cell carcinoma: A systematic review of candidate biomarkers.
Huisman BW, Burggraaf J, Vahrmeijer AL, Schoones JW, Rissmann RA, Sier CFM, van Poelgeest MIE
Gynecol Oncol 2020 Mar;156(3):734-743. Epub 2020 Jan 9 doi: 10.1016/j.ygyno.2019.12.030. PMID: 31928804
Prevalence and type distribution of human papillomavirus in squamous cell carcinoma and intraepithelial neoplasia of the vulva.
Faber MT, Sand FL, Albieri V, Norrild B, Kjaer SK, Verdoodt F
Int J Cancer 2017 Sep 15;141(6):1161-1169. Epub 2017 Jun 21 doi: 10.1002/ijc.30821. PMID: 28577297
Vulvar cancer: initial management and systematic review of literature on currently applied treatment approaches.
Sznurkowski JJ
Eur J Cancer Care (Engl) 2016 Jul;25(4):638-46. Epub 2016 Feb 16 doi: 10.1111/ecc.12455. PMID: 26880231
Primary groin irradiation versus primary groin surgery for early vulvar cancer.
van der Velden J, Fons G, Lawrie TA
Cochrane Database Syst Rev 2011 May 11;2011(5):CD002224. doi: 10.1002/14651858.CD002224.pub2. PMID: 21563133Free PMC Article
Chemoradiation for advanced primary vulval cancer.
Shylasree TS, Bryant A, Howells RE
Cochrane Database Syst Rev 2011 Apr 13;2011(4):CD003752. doi: 10.1002/14651858.CD003752.pub3. PMID: 21491387Free PMC Article

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