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Astrocytoma, IDH-mutant, grade 3

MedGen UID:
927513
Concept ID:
C4289981
Neoplastic Process
Synonyms: Anaplastic Astrocytoma, IDH-Mutant; Astrocytoma, IDH-Mutant, Grade 3; astrocytoma, IDH-mutant, grade 3; Astrocytoma, IDH-Mutant, Grade III
 
Monarch Initiative: MONDO:0956995

Definition

IDH-mutant astrocytoma characterized by the presence of increased mitotic activity and anaplastic features. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAstrocytoma, IDH-mutant, grade 3

Professional guidelines

PubMed

Segura PP, Quintela NV, García MM, Del Barco Berrón S, Sarrió RG, Gómez JG, Castaño AG, Martín LMN, Rubio OG, Losada EP
Clin Transl Oncol 2023 Sep;25(9):2634-2646. Epub 2023 Aug 4 doi: 10.1007/s12094-023-03245-y. PMID: 37540408Free PMC Article

Recent clinical studies

Etiology

Rautajoki KJ, Jaatinen S, Hartewig A, Tiihonen AM, Annala M, Salonen I, Valkonen M, Simola V, Vuorinen EM, Kivinen A, Rauhala MJ, Nurminen R, Maass KK, Lahtela SL, Jukkola A, Yli-Harja O, Helén P, Pajtler KW, Ruusuvuori P, Haapasalo J, Zhang W, Haapasalo H, Nykter M
Acta Neuropathol Commun 2023 Nov 6;11(1):176. doi: 10.1186/s40478-023-01669-9. PMID: 37932833Free PMC Article
Joyner DA, Garrett J, Batchala PP, Rama B, Ravicz JR, Patrie JT, Lopes MB, Fadul CE, Schiff D, Jain R, Patel SH
Neuroradiology 2023 Jan;65(1):121-129. Epub 2022 Aug 12 doi: 10.1007/s00234-022-03038-0. PMID: 35953567
Berger TR, Wen PY, Lang-Orsini M, Chukwueke UN
JAMA Oncol 2022 Oct 1;8(10):1493-1501. doi: 10.1001/jamaoncol.2022.2844. PMID: 36006639
Yang X, Xing Z, She D, Lin Y, Zhang H, Su Y, Cao D
BMC Med Imaging 2022 May 29;22(1):105. doi: 10.1186/s12880-022-00832-3. PMID: 35644621Free PMC Article
Ceccarelli M, Barthel FP, Malta TM, Sabedot TS, Salama SR, Murray BA, Morozova O, Newton Y, Radenbaugh A, Pagnotta SM, Anjum S, Wang J, Manyam G, Zoppoli P, Ling S, Rao AA, Grifford M, Cherniack AD, Zhang H, Poisson L, Carlotti CG Jr, Tirapelli DP, Rao A, Mikkelsen T, Lau CC, Yung WK, Rabadan R, Huse J, Brat DJ, Lehman NL, Barnholtz-Sloan JS, Zheng S, Hess K, Rao G, Meyerson M, Beroukhim R, Cooper L, Akbani R, Wrensch M, Haussler D, Aldape KD, Laird PW, Gutmann DH; TCGA Research Network, Noushmehr H, Iavarone A, Verhaak RG
Cell 2016 Jan 28;164(3):550-63. doi: 10.1016/j.cell.2015.12.028. PMID: 26824661Free PMC Article

Diagnosis

Weller M, Wen PY, Chang SM, Dirven L, Lim M, Monje M, Reifenberger G
Nat Rev Dis Primers 2024 May 9;10(1):33. doi: 10.1038/s41572-024-00516-y. PMID: 38724526
Horbinski C, Nabors LB, Portnow J, Baehring J, Bhatia A, Bloch O, Brem S, Butowski N, Cannon DM, Chao S, Chheda MG, Fabiano AJ, Forsyth P, Gigilio P, Hattangadi-Gluth J, Holdhoff M, Junck L, Kaley T, Merrell R, Mrugala MM, Nagpal S, Nedzi LA, Nevel K, Nghiemphu PL, Parney I, Patel TR, Peters K, Puduvalli VK, Rockhill J, Rusthoven C, Shonka N, Swinnen LJ, Weiss S, Wen PY, Willmarth NE, Bergman MA, Darlow S
J Natl Compr Canc Netw 2023 Jan;21(1):12-20. doi: 10.6004/jnccn.2023.0002. PMID: 36634606
Berger TR, Wen PY, Lang-Orsini M, Chukwueke UN
JAMA Oncol 2022 Oct 1;8(10):1493-1501. doi: 10.1001/jamaoncol.2022.2844. PMID: 36006639
Mohile NA, Messersmith H, Gatson NT, Hottinger AF, Lassman A, Morton J, Ney D, Nghiemphu PL, Olar A, Olson J, Perry J, Portnow J, Schiff D, Shannon A, Shih HA, Strowd R, van den Bent M, Ziu M, Blakeley J
J Clin Oncol 2022 Feb 1;40(4):403-426. Epub 2021 Dec 13 doi: 10.1200/JCO.21.02036. PMID: 34898238
Dono A, Ballester LY, Primdahl D, Esquenazi Y, Bhatia A
Curr Oncol Rep 2021 Jan 25;23(2):20. doi: 10.1007/s11912-020-01006-6. PMID: 33492489

Therapy

Rudà R, Horbinski C, van den Bent M, Preusser M, Soffietti R
Nat Rev Neurol 2024 Jul;20(7):395-407. Epub 2024 May 17 doi: 10.1038/s41582-024-00967-7. PMID: 38760442
Rautajoki KJ, Jaatinen S, Hartewig A, Tiihonen AM, Annala M, Salonen I, Valkonen M, Simola V, Vuorinen EM, Kivinen A, Rauhala MJ, Nurminen R, Maass KK, Lahtela SL, Jukkola A, Yli-Harja O, Helén P, Pajtler KW, Ruusuvuori P, Haapasalo J, Zhang W, Haapasalo H, Nykter M
Acta Neuropathol Commun 2023 Nov 6;11(1):176. doi: 10.1186/s40478-023-01669-9. PMID: 37932833Free PMC Article
Minniti G, Paolini S, Antonelli M, Gianno F, Tini P, Lanzetta G, Arcella A, De Pietro R, Giraffa M, Capone L, Romano A, Bozzao A, Esposito V
J Neurooncol 2023 Sep;164(2):331-339. Epub 2023 Sep 4 doi: 10.1007/s11060-023-04418-z. PMID: 37665475Free PMC Article
Jo J, Schiff D
Curr Treat Options Oncol 2022 Sep;23(9):1219-1232. Epub 2022 Aug 1 doi: 10.1007/s11864-022-01000-z. PMID: 35913658
Mohile NA, Messersmith H, Gatson NT, Hottinger AF, Lassman A, Morton J, Ney D, Nghiemphu PL, Olar A, Olson J, Perry J, Portnow J, Schiff D, Shannon A, Shih HA, Strowd R, van den Bent M, Ziu M, Blakeley J
J Clin Oncol 2022 Feb 1;40(4):403-426. Epub 2021 Dec 13 doi: 10.1200/JCO.21.02036. PMID: 34898238

Prognosis

Weller M, Wen PY, Chang SM, Dirven L, Lim M, Monje M, Reifenberger G
Nat Rev Dis Primers 2024 May 9;10(1):33. doi: 10.1038/s41572-024-00516-y. PMID: 38724526
Rautajoki KJ, Jaatinen S, Hartewig A, Tiihonen AM, Annala M, Salonen I, Valkonen M, Simola V, Vuorinen EM, Kivinen A, Rauhala MJ, Nurminen R, Maass KK, Lahtela SL, Jukkola A, Yli-Harja O, Helén P, Pajtler KW, Ruusuvuori P, Haapasalo J, Zhang W, Haapasalo H, Nykter M
Acta Neuropathol Commun 2023 Nov 6;11(1):176. doi: 10.1186/s40478-023-01669-9. PMID: 37932833Free PMC Article
Lee K, Kim SI, Kim EE, Shim YM, Won JK, Park CK, Choi SH, Yun H, Lee H, Park SH
Sci Rep 2023 Apr 25;13(1):6761. doi: 10.1038/s41598-023-32153-y. PMID: 37185778Free PMC Article
Berger TR, Wen PY, Lang-Orsini M, Chukwueke UN
JAMA Oncol 2022 Oct 1;8(10):1493-1501. doi: 10.1001/jamaoncol.2022.2844. PMID: 36006639
Mohile NA, Messersmith H, Gatson NT, Hottinger AF, Lassman A, Morton J, Ney D, Nghiemphu PL, Olar A, Olson J, Perry J, Portnow J, Schiff D, Shannon A, Shih HA, Strowd R, van den Bent M, Ziu M, Blakeley J
J Clin Oncol 2022 Feb 1;40(4):403-426. Epub 2021 Dec 13 doi: 10.1200/JCO.21.02036. PMID: 34898238

Clinical prediction guides

Minniti G, Paolini S, Antonelli M, Gianno F, Tini P, Lanzetta G, Arcella A, De Pietro R, Giraffa M, Capone L, Romano A, Bozzao A, Esposito V
J Neurooncol 2023 Sep;164(2):331-339. Epub 2023 Sep 4 doi: 10.1007/s11060-023-04418-z. PMID: 37665475Free PMC Article
Berger TR, Wen PY, Lang-Orsini M, Chukwueke UN
JAMA Oncol 2022 Oct 1;8(10):1493-1501. doi: 10.1001/jamaoncol.2022.2844. PMID: 36006639
Mohamed E, Kumar A, Zhang Y, Wang AS, Chen K, Lim Y, Shai A, Taylor JW, Clarke J, Hilz S, Berger MS, Solomon DA, Costello JF, Molinaro AM, Phillips JJ
Neuro Oncol 2022 Sep 1;24(9):1471-1481. doi: 10.1093/neuonc/noac064. PMID: 35287169Free PMC Article
Mohile NA, Messersmith H, Gatson NT, Hottinger AF, Lassman A, Morton J, Ney D, Nghiemphu PL, Olar A, Olson J, Perry J, Portnow J, Schiff D, Shannon A, Shih HA, Strowd R, van den Bent M, Ziu M, Blakeley J
J Clin Oncol 2022 Feb 1;40(4):403-426. Epub 2021 Dec 13 doi: 10.1200/JCO.21.02036. PMID: 34898238
Wong QH, Li KK, Wang WW, Malta TM, Noushmehr H, Grabovska Y, Jones C, Chan AK, Kwan JS, Huang QJ, Wong GC, Li WC, Liu XZ, Chen H, Chan DT, Mao Y, Zhang ZY, Shi ZF, Ng HK
Mod Pathol 2021 Jul;34(7):1245-1260. Epub 2021 Mar 10 doi: 10.1038/s41379-021-00778-x. PMID: 33692446

Recent systematic reviews

Tesileanu CMS, Vallentgoed WR, French PJ, van den Bent MJ
Eur J Cancer 2022 Nov;175:214-223. Epub 2022 Sep 21 doi: 10.1016/j.ejca.2022.08.016. PMID: 36152406
Halasz LM, Attia A, Bradfield L, Brat DJ, Kirkpatrick JP, Laack NN, Lalani N, Lebow ES, Liu AK, Niemeier HM, Palmer JD, Peters KB, Sheehan J, Thomas RP, Vora SA, Wahl DR, Weiss SE, Yeboa DN, Zhong J, Shih HA
Pract Radiat Oncol 2022 Sep-Oct;12(5):370-386. Epub 2022 May 31 doi: 10.1016/j.prro.2022.05.004. PMID: 35902341
Mohile NA, Messersmith H, Gatson NT, Hottinger AF, Lassman A, Morton J, Ney D, Nghiemphu PL, Olar A, Olson J, Perry J, Portnow J, Schiff D, Shannon A, Shih HA, Strowd R, van den Bent M, Ziu M, Blakeley J
J Clin Oncol 2022 Feb 1;40(4):403-426. Epub 2021 Dec 13 doi: 10.1200/JCO.21.02036. PMID: 34898238

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