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Astrocytoma, anaplastic

MedGen UID:
137784
Concept ID:
C0334579
Neoplastic Process
Synonyms: High-grade astrocytoma; Malignant astrocytoma
SNOMED CT: Malignant astrocytoma (55353007); Anaplastic astrocytoma (55353007); Astrocytoma, anaplastic (55353007)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0016684
Orphanet: ORPHA251589

Definition

A rare, high-grade, malignant glial tumor, histologically characterized by abundance of pleomorphic astrocytes and multiple mitotic figures, often associated with diffuse infiltration of the surrounding tissue, considerable edema and mass effect and involvement of the contralateral brain. Depending on the primary localization of the tumor, patients can present with signs of raised intracranial pressure (headache, vomiting, papilledema), seizures, progressive neurological deficits, and/or behavioral changes. The tumor is most commonly localized in the frontal and temporal lobes, brain stem and spinal cord. [from ORDO]

Professional guidelines

PubMed

Geurts M, Snijders TJ, van den Bent MJ
Curr Opin Oncol 2021 Nov 1;33(6):621-625. doi: 10.1097/CCO.0000000000000785. PMID: 34456249
Ruff MW, Uhm J
Curr Treat Options Oncol 2018 Oct 25;19(12):61. doi: 10.1007/s11864-018-0579-0. PMID: 30361986
Le Rhun E, Taillibert S, Chamberlain MC
Expert Rev Neurother 2015 Jun;15(6):601-20. Epub 2015 May 2 doi: 10.1586/14737175.2015.1042455. PMID: 25936680

Recent clinical studies

Etiology

Lebelt A, Rutkowski R, Och W, Jaczun K, Dziemiańczyk-Pakieła D, Milewski R, Mariak Z, Reszeć J
Adv Med Sci 2016 Sep;61(2):237-243. Epub 2016 Feb 12 doi: 10.1016/j.advms.2016.02.001. PMID: 26995334
Le Rhun E, Taillibert S, Chamberlain MC
Expert Rev Neurother 2015 Jun;15(6):601-20. Epub 2015 May 2 doi: 10.1586/14737175.2015.1042455. PMID: 25936680
Omuro A, DeAngelis LM
JAMA 2013 Nov 6;310(17):1842-50. doi: 10.1001/jama.2013.280319. PMID: 24193082
Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, Scheithauer BW, Kleihues P
Acta Neuropathol 2007 Aug;114(2):97-109. Epub 2007 Jul 6 doi: 10.1007/s00401-007-0243-4. PMID: 17618441Free PMC Article
McComb RD, Burger PC
Neurol Clin 1985 Nov;3(4):711-28. PMID: 3001488

Diagnosis

Wu X, Li Y, Glastonbury CM, Cha S
AJNR Am J Neuroradiol 2020 Apr;41(4):712-717. Epub 2020 Mar 12 doi: 10.3174/ajnr.A6471. PMID: 32165363Free PMC Article
Louis DN, Ellison DW, Brat DJ, Aldape K, Capper D, Hawkins C, Paulus W, Perry A, Reifenberger G, Figarella-Branger D, von Deimling A, Wesseling P
Brain Pathol 2019 Jul;29(4):469-472. Epub 2019 May 22 doi: 10.1111/bpa.12732. PMID: 31038238Free PMC Article
Le Rhun E, Taillibert S, Chamberlain MC
Expert Rev Neurother 2015 Jun;15(6):601-20. Epub 2015 May 2 doi: 10.1586/14737175.2015.1042455. PMID: 25936680
Omuro A, DeAngelis LM
JAMA 2013 Nov 6;310(17):1842-50. doi: 10.1001/jama.2013.280319. PMID: 24193082
McComb RD, Burger PC
Neurol Clin 1985 Nov;3(4):711-28. PMID: 3001488

Therapy

Khan L, Soliman H, Sahgal A, Perry J, Xu W, Tsao MN
Cochrane Database Syst Rev 2020 May 21;5(5):CD011475. doi: 10.1002/14651858.CD011475.pub3. PMID: 32437039Free PMC Article
Ramachandran RK, Sørensen MD, Aaberg-Jessen C, Hermansen SK, Kristensen BW
PLoS One 2017;12(2):e0172234. Epub 2017 Feb 24 doi: 10.1371/journal.pone.0172234. PMID: 28234925Free PMC Article
Burger MC, Zeiner PS, Jahnke K, Wagner M, Mittelbronn M, Steinbach JP
PLoS One 2016;11(6):e0155315. Epub 2016 Jun 2 doi: 10.1371/journal.pone.0155315. PMID: 27253224Free PMC Article
Rao RD, Krishnan S, Fitch TR, Schomberg PJ, Dinapoli RP, Nordstrom K, Scheithauer B, O'Fallon JR, Maurer MJ, Buckner JC
Int J Radiat Oncol Biol Phys 2005 Feb 1;61(2):380-6. doi: 10.1016/j.ijrobp.2004.06.258. PMID: 15667956
Tatter SB
Curr Treat Options Oncol 2002 Dec;3(6):509-24. doi: 10.1007/s11864-002-0070-8. PMID: 12392640

Prognosis

Rehfeld M, Matschke J, Hagel C, Willenborg K, Glatzel M, Bernreuther C
J Cancer Res Clin Oncol 2021 Oct;147(10):2969-2982. Epub 2021 Jun 25 doi: 10.1007/s00432-021-03704-5. PMID: 34170383Free PMC Article
Ramachandran RK, Sørensen MD, Aaberg-Jessen C, Hermansen SK, Kristensen BW
PLoS One 2017;12(2):e0172234. Epub 2017 Feb 24 doi: 10.1371/journal.pone.0172234. PMID: 28234925Free PMC Article
Isaacs H Jr
Childs Nerv Syst 2016 Nov;32(11):2085-2096. Epub 2016 Aug 27 doi: 10.1007/s00381-016-3215-y. PMID: 27568373Free PMC Article
Omuro A, DeAngelis LM
JAMA 2013 Nov 6;310(17):1842-50. doi: 10.1001/jama.2013.280319. PMID: 24193082
McComb RD, Burger PC
Neurol Clin 1985 Nov;3(4):711-28. PMID: 3001488

Clinical prediction guides

Schwake M, Kaneko S, Suero Molina E, Müther M, Schipmann S, Köchling M, Brentrup A, Stummer W
Acta Neurochir (Wien) 2019 Oct;161(10):2099-2105. Epub 2019 Aug 21 doi: 10.1007/s00701-019-04039-4. PMID: 31435824
Lebelt A, Rutkowski R, Och W, Jaczun K, Dziemiańczyk-Pakieła D, Milewski R, Mariak Z, Reszeć J
Adv Med Sci 2016 Sep;61(2):237-243. Epub 2016 Feb 12 doi: 10.1016/j.advms.2016.02.001. PMID: 26995334
Mathew RK, O'Kane R, Parslow R, Stiller C, Kenny T, Picton S, Chumas PD
Neuro Oncol 2014 Aug;16(8):1137-45. Epub 2014 May 5 doi: 10.1093/neuonc/nou056. PMID: 24799454Free PMC Article
Jung KW, Yoo H, Kong HJ, Won YJ, Park S, Lee SH
J Neurooncol 2012 Sep;109(2):301-7. Epub 2012 Jun 4 doi: 10.1007/s11060-012-0893-5. PMID: 22660961
Dean BL, Drayer BP, Bird CR, Flom RA, Hodak JA, Coons SW, Carey RG
Radiology 1990 Feb;174(2):411-5. doi: 10.1148/radiology.174.2.2153310. PMID: 2153310

Recent systematic reviews

Khan L, Soliman H, Sahgal A, Perry J, Xu W, Tsao MN
Cochrane Database Syst Rev 2020 May 21;5(5):CD011475. doi: 10.1002/14651858.CD011475.pub3. PMID: 32437039Free PMC Article

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