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Keratosis

MedGen UID:
9625
•Concept ID:
C0022593
•
Disease or Syndrome
Synonym: Keratoses
SNOMED CT: Keratosis (254666005); Hyperkeratosis (254666005)
 
Monarch Initiative: MONDO:0006566

Definition

Excessive growth of keratin on the skin. [from NCI]

Professional guidelines

PubMed

Treatment of keratosis pilaris and its variants: a systematic review.
Maghfour J, Ly S, Haidari W, Taylor SL, Feldman SR
J Dermatolog Treat 2022 May;33(3):1231-1242. Epub 2020 Sep 14 doi: 10.1080/09546634.2020.1818678. PMID: 32886029
Lentigo maligna: diagnosis and treatment.
De Luca EV, Perino F, Di Stefani A, Coco V, Fossati B, Peris K
G Ital Dermatol Venereol 2020 Apr;155(2):179-189. Epub 2018 Apr 19 doi: 10.23736/S0392-0488.18.06003-0. PMID: 29683288
Albinism: epidemiology, genetics, cutaneous characterization, psychosocial factors.
Marçon CR, Maia M
An Bras Dermatol 2019 Sep-Oct;94(5):503-520. Epub 2019 Sep 30 doi: 10.1016/j.abd.2019.09.023. PMID: 31777350Free PMC Article

Recent clinical studies

Etiology

Treatment of actinic keratosis: a systematic review.
Worley B, Harikumar V, Reynolds K, Dirr MA, Christensen RE, Anvery N, Yi MD, Poon E, Alam M
Arch Dermatol Res 2023 Jul;315(5):1099-1108. Epub 2022 Dec 1 doi: 10.1007/s00403-022-02490-5. PMID: 36454335
Update of pathophysiology and treatment options of seborrheic keratosis.
Gorai S, Ahmad S, Raza SSM, Khan HD, Raza MA, Etaee F, Cockerell CJ, Apalla Z, Goldust M
Dermatol Ther 2022 Dec;35(12):e15934. Epub 2022 Nov 1 doi: 10.1111/dth.15934. PMID: 36226729
Guidelines of care for the management of actinic keratosis.
Eisen DB, Asgari MM, Bennett DD, Connolly SM, Dellavalle RP, Freeman EE, Goldenberg G, Leffell DJ, Peschin S, Sligh JE, Wu PA, Frazer-Green L, Malik S, Schlesinger TE
J Am Acad Dermatol 2021 Oct;85(4):e209-e233. Epub 2021 Apr 2 doi: 10.1016/j.jaad.2021.02.082. PMID: 33820677
Actinic keratoses: review of clinical, dermoscopic, and therapeutic aspects.
Reinehr CPH, Bakos RM
An Bras Dermatol 2019 Nov-Dec;94(6):637-657. Epub 2019 Nov 6 doi: 10.1016/j.abd.2019.10.004. PMID: 31789244Free PMC Article
The status of the seborrheic keratosis.
Karadag AS, Parish LC
Clin Dermatol 2018 Mar-Apr;36(2):275-277. Epub 2017 Sep 8 doi: 10.1016/j.clindermatol.2017.09.011. PMID: 29566932

Diagnosis

Seborrheic keratosis-like melanoma: a diagnostic challenge.
Janowska A, Oranges T, Iannone M, Romanelli M, Dini V
Melanoma Res 2021 Oct 1;31(5):407-412. doi: 10.1097/CMR.0000000000000756. PMID: 34132226
Actinic keratoses: review of clinical, dermoscopic, and therapeutic aspects.
Reinehr CPH, Bakos RM
An Bras Dermatol 2019 Nov-Dec;94(6):637-657. Epub 2019 Nov 6 doi: 10.1016/j.abd.2019.10.004. PMID: 31789244Free PMC Article
Recent advances in managing and understanding seborrheic keratosis.
Wollina U
F1000Res 2019;8 Epub 2019 Aug 28 doi: 10.12688/f1000research.18983.1. PMID: 31508199Free PMC Article
Frictional Keratosis, Contact Keratosis and Smokeless Tobacco Keratosis: Features of Reactive White Lesions of the Oral Mucosa.
Müller S
Head Neck Pathol 2019 Mar;13(1):16-24. Epub 2019 Jan 22 doi: 10.1007/s12105-018-0986-3. PMID: 30671762Free PMC Article
Real-world approach to actinic keratosis management: practical treatment algorithm for office-based dermatology.
Dirschka T, Gupta G, Micali G, Stockfleth E, Basset-Séguin N, Del Marmol V, Dummer R, Jemec GBE, Malvehy J, Peris K, Puig S, Stratigos AJ, Zalaudek I, Pellacani G
J Dermatolog Treat 2017 Aug;28(5):431-442. Epub 2016 Nov 13 doi: 10.1080/09546634.2016.1254328. PMID: 27796187

Therapy

Treatment of actinic keratosis: a systematic review.
Worley B, Harikumar V, Reynolds K, Dirr MA, Christensen RE, Anvery N, Yi MD, Poon E, Alam M
Arch Dermatol Res 2023 Jul;315(5):1099-1108. Epub 2022 Dec 1 doi: 10.1007/s00403-022-02490-5. PMID: 36454335
Guidelines of care for the management of actinic keratosis.
Eisen DB, Asgari MM, Bennett DD, Connolly SM, Dellavalle RP, Freeman EE, Goldenberg G, Leffell DJ, Peschin S, Sligh JE, Wu PA, Frazer-Green L, Malik S, Schlesinger TE
J Am Acad Dermatol 2021 Oct;85(4):e209-e233. Epub 2021 Apr 2 doi: 10.1016/j.jaad.2021.02.082. PMID: 33820677
Field cancerization: Treatment.
Cornejo CM, Jambusaria-Pahlajani A, Willenbrink TJ, Schmults CD, Arron ST, Ruiz ES
J Am Acad Dermatol 2020 Sep;83(3):719-730. Epub 2020 May 6 doi: 10.1016/j.jaad.2020.03.127. PMID: 32387663
The Role of Nicotinamide in Cancer Chemoprevention and Therapy.
Nikas IP, Paschou SA, Ryu HS
Biomolecules 2020 Mar 20;10(3) doi: 10.3390/biom10030477. PMID: 32245130Free PMC Article
Nicotinamide for photoprotection and skin cancer chemoprevention: A review of efficacy and safety.
Snaidr VA, Damian DL, Halliday GM
Exp Dermatol 2019 Feb;28 Suppl 1:15-22. doi: 10.1111/exd.13819. PMID: 30698874

Prognosis

Field cancerization: Definition, epidemiology, risk factors, and outcomes.
Willenbrink TJ, Ruiz ES, Cornejo CM, Schmults CD, Arron ST, Jambusaria-Pahlajani A
J Am Acad Dermatol 2020 Sep;83(3):709-717. Epub 2020 May 7 doi: 10.1016/j.jaad.2020.03.126. PMID: 32387665
Keratosis Pilaris.
Pediatr Dermatol 2019 Nov;36(6):937-938. doi: 10.1111/pde.14062. PMID: 31778553
Randomized Trial of Four Treatment Approaches for Actinic Keratosis.
Jansen MHE, Kessels JPHM, Nelemans PJ, Kouloubis N, Arits AHMM, van Pelt HPA, Quaedvlieg PJF, Essers BAB, Steijlen PM, Kelleners-Smeets NWJ, Mosterd K
N Engl J Med 2019 Mar 7;380(10):935-946. doi: 10.1056/NEJMoa1811850. PMID: 30855743
Psoriasiform keratosis.
Walsh SN, Hurt MA, Santa Cruz DJ
Am J Dermatopathol 2007 Apr;29(2):137-40. doi: 10.1097/01.dad.0000246177.63145.b3. PMID: 17414434
Acrokeratoelastoidosis.
Hu W, Cook TF, Vicki GJ, Glaser DA
Pediatr Dermatol 2002 Jul-Aug;19(4):320-2. doi: 10.1046/j.1525-1470.2002.00091.x. PMID: 12220276

Clinical prediction guides

Topical simvastatin-cholesterol for disseminated superficial actinic porokeratosis: An open-label, split-body clinical trial.
Byth LA, Byth J
Australas J Dermatol 2021 Aug;62(3):310-313. Epub 2021 May 24 doi: 10.1111/ajd.13601. PMID: 34028808
Artificial intelligence in dermatopathology: Diagnosis, education, and research.
Wells A, Patel S, Lee JB, Motaparthi K
J Cutan Pathol 2021 Aug;48(8):1061-1068. Epub 2021 Jan 26 doi: 10.1111/cup.13954. PMID: 33421167
Ingenol mebutate in actinic keratosis: a clinical, videodermoscopic and immunohistochemical study.
Bobyr I, Campanati A, Consales V, Martina E, Molinelli E, Diotallevi F, Brisigotti V, Giangiacomi M, Ganzetti G, Giuliodori K, Offidani A
J Eur Acad Dermatol Venereol 2017 Feb;31(2):260-266. Epub 2016 Jul 25 doi: 10.1111/jdv.13831. PMID: 27453064
Actinic Keratosis Pathogenesis Update and New Patents.
Cantisani C, Paolino G, Melis M, Faina V, Romaniello F, Didona D, Cardone M, Calvieri S
Recent Pat Inflamm Allergy Drug Discov 2016;10(1):40-48. doi: 10.2174/1872213x10666160504104825. PMID: 27142784
Diagnosis of arsenicosis.
Saha KC
J Environ Sci Health A Tox Hazard Subst Environ Eng 2003 Jan;38(1):255-72. doi: 10.1081/ese-120016893. PMID: 12635831

Recent systematic reviews

Treatment of actinic keratosis: a systematic review.
Worley B, Harikumar V, Reynolds K, Dirr MA, Christensen RE, Anvery N, Yi MD, Poon E, Alam M
Arch Dermatol Res 2023 Jul;315(5):1099-1108. Epub 2022 Dec 1 doi: 10.1007/s00403-022-02490-5. PMID: 36454335
Evidence-Based Clinical Practice Guidelines for Laser-Assisted Drug Delivery.
Labadie JG, Ibrahim SA, Worley B, Kang BY, Rakita U, Rigali S, Arndt KA, Bernstein E, Brauer JA, Chandra S, Didwania A, DiGiorgio C, Donelan M, Dover JS, Galadari H, Geronemus RG, Goldman MP, Haedersdal M, Hruza G, Ibrahimi OA, Kauvar A, Kelly KM, Krakowski AC, Miest R, Orringer JS, Ozog DM, Ross EV, Shumaker PR, Sobanko JF, Suozzi K, Taylor MB, Teng JMC, Uebelhoer NS, Waibel J, Wanner M, Ratchev I, Christensen RE, Poon E, Miller CH, Alam M
JAMA Dermatol 2022 Oct 1;158(10):1193-1201. doi: 10.1001/jamadermatol.2022.3234. PMID: 35976634
Treatment of keratosis pilaris and its variants: a systematic review.
Maghfour J, Ly S, Haidari W, Taylor SL, Feldman SR
J Dermatolog Treat 2022 May;33(3):1231-1242. Epub 2020 Sep 14 doi: 10.1080/09546634.2020.1818678. PMID: 32886029
Guidelines of care for the management of actinic keratosis.
Eisen DB, Asgari MM, Bennett DD, Connolly SM, Dellavalle RP, Freeman EE, Goldenberg G, Leffell DJ, Peschin S, Sligh JE, Wu PA, Frazer-Green L, Malik S, Schlesinger TE
J Am Acad Dermatol 2021 Oct;85(4):e209-e233. Epub 2021 Apr 2 doi: 10.1016/j.jaad.2021.02.082. PMID: 33820677
Worldwide prevalence of oral lichen planus: A systematic review and meta-analysis.
González-Moles MÁ, Warnakulasuriya S, González-Ruiz I, González-Ruiz L, Ayén Á, Lenouvel D, Ruiz-Ávila I, Ramos-García P
Oral Dis 2021 May;27(4):813-828. Epub 2020 Apr 2 doi: 10.1111/odi.13323. PMID: 32144836

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