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Seborrheic keratosis

MedGen UID:
5957
Concept ID:
C0022603
Neoplastic Process
Synonyms: Keratosis Seborrheica; Keratosis, seborrheic, somatic; Seborrheic keratoses
SNOMED CT: Basal cell papilloma (394726009); BCP - Basal cell papilloma (394726009); Seborrheic wart (394726009); Seborrheic keratosis (394726009); Pigmented basal cell papilloma (394726009); Seborrheic keratosis (25499005); Basal cell papilloma (25499005); Basosquamous papilloma (25499005); Seborrheic verruca (25499005); Keratosis seborrheica (25499005); Verruca seborrheica (25499005); Seborrheic wart (25499005)
 
Gene (location): PIK3CA (3q26.32)
 
HPO: HP:0031287
Monarch Initiative: MONDO:0008420
OMIM®: 182000

Definition

Seborrheic keratoses are common benign epidermal lesion that can develop on any part of the body. [from OMIM]

Clinical features

From HPO
Seborrheic keratosis
MedGen UID:
5957
Concept ID:
C0022603
Neoplastic Process
Seborrheic keratoses are common benign epidermal lesion that can develop on any part of the body.
Epidermal nevus
MedGen UID:
83106
Concept ID:
C0334082
Disease or Syndrome
PIK3CA-related overgrowth spectrum (PROS) encompasses a range of clinical findings in which the core features are congenital or early-childhood onset of segmental/focal overgrowth with or without cellular dysplasia. Prior to the identification of PIK3CA as the causative gene, PROS was separated into distinct clinical syndromes based on the tissues and/or organs involved (e.g., MCAP [megalencephaly-capillary malformation] syndrome and CLOVES [congenital lipomatous asymmetric overgrowth of the trunk, lymphatic, capillary, venous, and combined-type vascular malformations, epidermal nevi, skeletal and spinal anomalies] syndrome). The predominant areas of overgrowth include the brain, limbs (including fingers and toes), trunk (including abdomen and chest), and face, all usually in an asymmetric distribution. Generalized brain overgrowth may be accompanied by secondary overgrowth of specific brain structures resulting in ventriculomegaly, a markedly thick corpus callosum, and cerebellar tonsillar ectopia with crowding of the posterior fossa. Vascular malformations may include capillary, venous, and less frequently, arterial or mixed (capillary-lymphatic-venous or arteriovenous) malformations. Lymphatic malformations may be in various locations (internal and/or external) and can cause various clinical issues, including swelling, pain, and occasionally localized bleeding secondary to trauma. Lipomatous overgrowth may occur ipsilateral or contralateral to a vascular malformation, if present. The degree of intellectual disability appears to be mostly related to the presence and severity of seizures, cortical dysplasia (e.g., polymicrogyria), and hydrocephalus. Many children have feeding difficulties that are often multifactorial in nature. Endocrine issues affect a small number of individuals and most commonly include hypoglycemia (largely hypoinsulinemic hypoketotic hypoglycemia), hypothyroidism, and growth hormone deficiency.

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSeborrheic keratosis

Conditions with this feature

Seborrheic keratosis
MedGen UID:
5957
Concept ID:
C0022603
Neoplastic Process
Seborrheic keratoses are common benign epidermal lesion that can develop on any part of the body.
Xeroderma pigmentosum, group F
MedGen UID:
120612
Concept ID:
C0268140
Congenital Abnormality
Xeroderma pigmentosum (XP) is characterized by: Acute sun sensitivity (severe sunburn with blistering, persistent erythema on minimal sun exposure) with marked freckle-like pigmentation of the face before age two years; Sunlight-induced ocular involvement (photophobia, severe keratitis, atrophy of the skin of the lids, ocular surface neoplasms); Greatly increased risk of sunlight-induced cutaneous neoplasms (basal cell carcinoma, squamous cell carcinoma, melanoma) within the first decade of life. Approximately 25% of affected individuals have neurologic manifestations (acquired microcephaly, diminished or absent deep tendon stretch reflexes, progressive sensorineural hearing loss, progressive cognitive impairment, and ataxia). The most common causes of death are skin cancer, neurologic degeneration, and internal cancer. The median age at death in persons with XP with neurodegeneration (29 years) was found to be younger than that in persons with XP without neurodegeneration (37 years).

Professional guidelines

PubMed

Pokhrel PK, Helm MF, Greene A, Helm LA, Partin M
Prim Care 2022 Mar;49(1):99-118. Epub 2022 Jan 3 doi: 10.1016/j.pop.2021.10.004. PMID: 35125161
De Luca EV, Perino F, Di Stefani A, Coco V, Fossati B, Peris K
G Ital Dermatol Venereol 2020 Apr;155(2):179-189. Epub 2018 Apr 19 doi: 10.23736/S0392-0488.18.06003-0. PMID: 29683288
Rowe B, Yosipovitch G
Curr Probl Dermatol 2016;50:149-54. Epub 2016 Aug 23 doi: 10.1159/000446060. PMID: 27578084

Recent clinical studies

Etiology

Gorai S, Ahmad S, Raza SSM, Khan HD, Raza MA, Etaee F, Cockerell CJ, Apalla Z, Goldust M
Dermatol Ther 2022 Dec;35(12):e15934. Epub 2022 Nov 1 doi: 10.1111/dth.15934. PMID: 36226729
Goldsmith JF, Montaser Kouhsari L, Tahan SR
Am J Surg Pathol 2022 Dec 1;46(12):1642-1649. Epub 2022 Oct 11 doi: 10.1097/PAS.0000000000001973. PMID: 36221316
Burgess CM
J Drugs Dermatol 2019 Jul 1;18(7):615. PMID: 31329381
Karadag AS, Parish LC
Clin Dermatol 2018 Mar-Apr;36(2):275-277. Epub 2017 Sep 8 doi: 10.1016/j.clindermatol.2017.09.011. PMID: 29566932
Walsh SN, Hurt MA, Santa Cruz DJ
Am J Dermatopathol 2007 Apr;29(2):137-40. doi: 10.1097/01.dad.0000246177.63145.b3. PMID: 17414434

Diagnosis

Ticknor IL, Cassarino DS
Am J Dermatopathol 2023 Dec 1;45(12):822-824. doi: 10.1097/DAD.0000000000002572. PMID: 37883954
Barthelmann S, Butsch F, Lang BM, Stege H, Großmann B, Schepler H, Grabbe S
J Dtsch Dermatol Ges 2023 Mar;21(3):265-277. Epub 2023 Mar 9 doi: 10.1111/ddg.14984. PMID: 36892019
Pokhrel PK, Helm MF, Greene A, Helm LA, Partin M
Prim Care 2022 Mar;49(1):99-118. Epub 2022 Jan 3 doi: 10.1016/j.pop.2021.10.004. PMID: 35125161
Wollina U
F1000Res 2019;8 Epub 2019 Aug 28 doi: 10.12688/f1000research.18983.1. PMID: 31508199Free PMC Article
Hafner C, Vogt T
J Dtsch Dermatol Ges 2008 Aug;6(8):664-77. doi: 10.1111/j.1610-0387.2008.06788.x. PMID: 18801147

Therapy

Burgess CM
J Drugs Dermatol 2019 Jul 1;18(7):615. PMID: 31329381
Czyz M
Cells 2019 Jun 4;8(6) doi: 10.3390/cells8060540. PMID: 31167513Free PMC Article
Kao S, Kiss A, Efimova T, Friedman AJ
J Drugs Dermatol 2018 Sep 1;17(9):933-940. PMID: 30235378
Rowe B, Yosipovitch G
Curr Probl Dermatol 2016;50:149-54. Epub 2016 Aug 23 doi: 10.1159/000446060. PMID: 27578084
Hafner C, Vogt T
J Dtsch Dermatol Ges 2008 Aug;6(8):664-77. doi: 10.1111/j.1610-0387.2008.06788.x. PMID: 18801147

Prognosis

Pokhrel PK, Helm MF, Greene A, Helm LA, Partin M
Prim Care 2022 Mar;49(1):99-118. Epub 2022 Jan 3 doi: 10.1016/j.pop.2021.10.004. PMID: 35125161
Czyz M
Cells 2019 Jun 4;8(6) doi: 10.3390/cells8060540. PMID: 31167513Free PMC Article
Takai T
J Dermatol 2017 Mar;44(3):304-314. doi: 10.1111/1346-8138.13696. PMID: 28256761
Walsh SN, Hurt MA, Santa Cruz DJ
Am J Dermatopathol 2007 Apr;29(2):137-40. doi: 10.1097/01.dad.0000246177.63145.b3. PMID: 17414434
Panizzon RG
Semin Dermatol 1996 Mar;15(1):67-70. doi: 10.1016/s1085-5629(96)80021-6. PMID: 8723827

Clinical prediction guides

Goldsmith JF, Montaser Kouhsari L, Tahan SR
Am J Surg Pathol 2022 Dec 1;46(12):1642-1649. Epub 2022 Oct 11 doi: 10.1097/PAS.0000000000001973. PMID: 36221316
Lin CY, Kuo TT, Chang YC
Am J Dermatopathol 2022 Jan 1;44(1):17-20. doi: 10.1097/DAD.0000000000001998. PMID: 34132661
Lu Q, Wang S, Wu T, Jiang G
J Coll Physicians Surg Pak 2021 Apr;31(4):450-454. doi: 10.29271/jcpsp.2021.04.450. PMID: 33866733
Wells A, Patel S, Lee JB, Motaparthi K
J Cutan Pathol 2021 Aug;48(8):1061-1068. Epub 2021 Jan 26 doi: 10.1111/cup.13954. PMID: 33421167
Kim KW, Chang J, Lee S, Im GJ, Chae SW, Jung HH, Choi J
Eur Arch Otorhinolaryngol 2015 May;272(5):1113-7. Epub 2014 Feb 11 doi: 10.1007/s00405-014-2921-x. PMID: 24515921

Recent systematic reviews

Natarelli N, Krenitsky A, Hennessy K, Moore S, Grichnik J
J Dermatolog Treat 2023 Dec;34(1):2133532. Epub 2022 Nov 13 doi: 10.1080/09546634.2022.2133532. PMID: 36215682
Funkhouser CH, Coerdt KM, Haidari W, Cardis MA
Ann Pharmacother 2021 Feb;55(2):216-221. Epub 2020 Jul 10 doi: 10.1177/1060028020941793. PMID: 32646224
Todorova K, Mandinova A
Adv Drug Deliv Rev 2020 Jan 1;153:18-27. Epub 2020 Jun 8 doi: 10.1016/j.addr.2020.06.004. PMID: 32526451
Navarrete-Dechent C, DeRosa AP, Longo C, Liopyris K, Oliviero M, Rabinovitz H, Marghoob AA, Halpern AC, Pellacani G, Scope A, Jain M
J Am Acad Dermatol 2019 May;80(5):1414-1427.e3. Epub 2018 Dec 8 doi: 10.1016/j.jaad.2018.12.007. PMID: 30529706Free PMC Article
Wat H, Dytoc M
J Cutan Med Surg 2014 Mar-Apr;18(2):91-108. doi: 10.2310/7750.2013.13109. PMID: 24636434

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