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Abnormal mandible morphology

MedGen UID:
871374
•Concept ID:
C4025870
•
Anatomical Abnormality
Synonym: Abnormality of the mandible
 
HPO: HP:0000277

Definition

Any abnormality of the mandible, the bone of the lower jaw. [from HPO]

Conditions with this feature

Osteomas of mandible
MedGen UID:
318953
•Concept ID:
C1833733
•
Disease or Syndrome
See: Condition Record
Multiple pterygium-malignant hyperthermia syndrome
MedGen UID:
347490
•Concept ID:
C1857576
•
Disease or Syndrome
An extremely rare arthrogryposis syndrome, described in only two pairs of siblings from two unrelated families to date, and characterized by the association of arthrogryposis, congenital torticollis, dysmorphic facial features (i.e. asymmetry of the face, myopathic facial movements, ptosis, posteriorly rotated ears, cleft palate), progressive scoliosis and episodes of malignant hyperthermia. There have been no further descriptions in the literature since 1988.
See: Condition Record
Multiple pterygium-malignant hyperthermia syndrome
Osteomas of mandible

Professional guidelines

PubMed

The etiology, clinical features, and treatment options of hemifacial microsomia.
Luo S, Sun H, Bian Q, Liu Z, Wang X
Oral Dis 2023 Sep;29(6):2449-2462. Epub 2023 Mar 13 doi: 10.1111/odi.14508. PMID: 36648381
Hypodontia: An Update on Its Etiology, Classification, and Clinical Management.
Al-Ani AH, Antoun JS, Thomson WM, Merriman TR, Farella M
Biomed Res Int 2017;2017:9378325. Epub 2017 Mar 19 doi: 10.1155/2017/9378325. PMID: 28401166Free PMC Article
Controversies in the diagnosis and management of the Robin sequence.
Mackay DR
J Craniofac Surg 2011 Mar;22(2):415-20. doi: 10.1097/SCS.0b013e3182074799. PMID: 21403570

Recent clinical studies

Therapy

Denosumab Therapy in Cherubism.
Liles SI, C Hoppe I, Arnold L
Cleft Palate Craniofac J 2023 Dec;60(12):1665-1673. Epub 2022 Jul 12 doi: 10.1177/10556656221113891. PMID: 35821585
Robin Sequence: Neonatal Mandibular Distraction.
Morrison KA, Collares MV, Flores RL
Clin Plast Surg 2021 Jul;48(3):363-373. Epub 2021 May 8 doi: 10.1016/j.cps.2021.03.005. PMID: 34051891
Orthodontic considerations in restorative management of hypodontia patients with endosseous implants.
Borzabadi-Farahani A
J Oral Implantol 2012 Dec;38(6):779-91. Epub 2011 Jul 5 doi: 10.1563/AAID-JOI-D-11-00022. PMID: 21728818
MOC-PS(SM) CME article: genioplasty.
Guyuron B
Plast Reconstr Surg 2008 Apr;121(4 Suppl):1-7. doi: 10.1097/01.prs.0000305931.98111.c3. PMID: 18379385
Genioplasty.
Stanton DC
Facial Plast Surg 2003 Feb;19(1):75-86. doi: 10.1055/s-2003-39130. PMID: 12739183

Prognosis

The ontogeny of Robin sequence.
Logjes RJH, Breugem CC, Van Haaften G, Paes EC, Sperber GH, van den Boogaard MH, Farlie PG
Am J Med Genet A 2018 Jun;176(6):1349-1368. Epub 2018 Apr 25 doi: 10.1002/ajmg.a.38718. PMID: 29696787
Impacted and transmigrant mandibular canines incidence, aetiology, and treatment: a systematic review.
Dalessandri D, Parrini S, Rubiano R, Gallone D, Migliorati M
Eur J Orthod 2017 Apr 1;39(2):161-169. doi: 10.1093/ejo/cjw027. PMID: 27036134
Hanhart syndrome.
Dogan DG, Dogan M, Aslan M, Menekse E, Yakinci C
Genet Couns 2010;21(4):359-62. PMID: 21290964
Current perspectives on the etiology of agnathia-otocephaly.
Gekas J, Li B, Kamnasaran D
Eur J Med Genet 2010 Nov-Dec;53(6):358-66. Epub 2010 Sep 16 doi: 10.1016/j.ejmg.2010.09.002. PMID: 20849990
Cherubism: clinicopathologic features.
Yamaguchi T, Dorfman HD, Eisig S
Skeletal Radiol 1999 Jun;28(6):350-3. doi: 10.1007/s002560050530. PMID: 10450884

Clinical prediction guides

Craniofacial Microsomia: New Updates in Spinal Anomalies.
Gonçalves Ferraz B, Vendramini-Pittoli S, Gomes LP, Madeira Brandão M, Alonso N, Tonello C
J Craniofac Surg 2023 Jun 1;34(4):e398-e401. Epub 2023 May 1 doi: 10.1097/SCS.0000000000009326. PMID: 37126414
Three-dimensional analysis of mandible ramus morphology and transverse stability after intraoral vertical ramus osteotomy.
Huang L, Tang S, Yan J, Liu Y, Piao Z
Surg Radiol Anat 2022 Apr;44(4):551-558. Epub 2022 Mar 18 doi: 10.1007/s00276-022-02912-z. PMID: 35303119Free PMC Article
Quantification of the relative orientation and position of the mandibular condyles.
Bescond G, Gales M, Glineur R, Bonnechère B, Sholukha V, Louryan S, Van Sint Jan S
Morphologie 2021 Dec;105(351):275-280. Epub 2020 Dec 2 doi: 10.1016/j.morpho.2020.11.007. PMID: 33279396
Hypodontia: An Update on Its Etiology, Classification, and Clinical Management.
Al-Ani AH, Antoun JS, Thomson WM, Merriman TR, Farella M
Biomed Res Int 2017;2017:9378325. Epub 2017 Mar 19 doi: 10.1155/2017/9378325. PMID: 28401166Free PMC Article
Hemimandibular hyperplasia--hemimandibular elongation.
Obwegeser HL, Makek MS
J Maxillofac Surg 1986 Aug;14(4):183-208. doi: 10.1016/s0301-0503(86)80290-9. PMID: 3461097

Recent systematic reviews

Peripheral odontogenic keratocyst: Clinicopathological and immunohistochemical characterization.
Lafuente-Ibáñez de Mendoza I, Aguirre-Urizar JM, Villatoro-Ugalde V, Magaña-Quiñones JJ, Lana-Ojeda J, Mosqueda-Taylor A
Oral Dis 2022 May;28(4):1198-1206. Epub 2021 Mar 21 doi: 10.1111/odi.13834. PMID: 33682271
Will This Patient Be Difficult to Intubate?: The Rational Clinical Examination Systematic Review.
Detsky ME, Jivraj N, Adhikari NK, Friedrich JO, Pinto R, Simel DL, Wijeysundera DN, Scales DC
JAMA 2019 Feb 5;321(5):493-503. doi: 10.1001/jama.2018.21413. PMID: 30721300
Craniofacial and upper airway morphology in adult obstructive sleep apnea patients: A systematic review and meta-analysis of cephalometric studies.
Neelapu BC, Kharbanda OP, Sardana HK, Balachandran R, Sardana V, Kapoor P, Gupta A, Vasamsetti S
Sleep Med Rev 2017 Feb;31:79-90. Epub 2016 Jan 30 doi: 10.1016/j.smrv.2016.01.007. PMID: 27039222
Impacted and transmigrant mandibular canines incidence, aetiology, and treatment: a systematic review.
Dalessandri D, Parrini S, Rubiano R, Gallone D, Migliorati M
Eur J Orthod 2017 Apr 1;39(2):161-169. doi: 10.1093/ejo/cjw027. PMID: 27036134
Morphologic and Demographic Predictors of Third Molar Agenesis: A Systematic Review and Meta-analysis.
Carter K, Worthington S
J Dent Res 2015 Jul;94(7):886-94. Epub 2015 Apr 16 doi: 10.1177/0022034515581644. PMID: 25883107

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