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EGFR-related lung cancer(EGFR)

MedGen UID:
472093
•Concept ID:
CN130014
•
Disease or Syndrome
Synonym: EGFR

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  

Professional guidelines

PubMed

Gefitinib (Iressa): a novel treatment for non-small cell lung cancer.
Vansteenkiste J
Expert Rev Anticancer Ther 2004 Feb;4(1):5-17. doi: 10.1586/14737140.4.1.5. PMID: 14748652

Curated

Epidermal growth factor receptor tyrosine kinase (EGFR-TK) mutation testing in adults with locally advanced or metastatic non-small cell lung cancer: a systematic review and cost-effectiveness analysis.
Westwood M, Joore M, Whiting P, van Asselt T, Ramaekers B, Armstrong N, Misso K, Severens J, Kleijnen J
Health Technol Assess 2014 May;18(32):1-166. doi: 10.3310/hta18320. PMID: 24827857Free PMC Article

Suggested Reading

PubMed

Non-small cell lung cancer and precision medicine: a model for the incorporation of genomic features into clinical trial design.
Pasche B, Grant SC
JAMA 2014 May 21;311(19):1975-6. doi: 10.1001/jama.2014.3742. PMID: 24846033

Recent clinical studies

Etiology

Amivantamab plus Lazertinib in Previously Untreated EGFR-Mutated Advanced NSCLC.
Cho BC, Lu S, Felip E, Spira AI, Girard N, Lee JS, Lee SH, Ostapenko Y, Danchaivijitr P, Liu B, Alip A, Korbenfeld E, Mourão Dias J, Besse B, Lee KH, Xiong H, How SH, Cheng Y, Chang GC, Yoshioka H, Yang JC, Thomas M, Nguyen D, Ou SI, Mukhedkar S, Prabhash K, D'Arcangelo M, Alatorre-Alexander J, Vázquez Limón JC, Alves S, Stroyakovskiy D, Peregudova M, Şendur MAN, Yazici O, Califano R, Gutiérrez Calderón V, de Marinis F, Passaro A, Kim SW, Gadgeel SM, Xie J, Sun T, Martinez M, Ennis M, Fennema E, Daksh M, Millington D, Leconte I, Iwasawa R, Lorenzini P, Baig M, Shah S, Bauml JM, Shreeve SM, Sethi S, Knoblauch RE, Hayashi H; MARIPOSA Investigators
N Engl J Med 2024 Oct 24;391(16):1486-1498. Epub 2024 Jun 26 doi: 10.1056/NEJMoa2403614. PMID: 38924756
Amivantamab plus Chemotherapy in NSCLC with EGFR Exon 20 Insertions.
Zhou C, Tang KJ, Cho BC, Liu B, Paz-Ares L, Cheng S, Kitazono S, Thiagarajan M, Goldman JW, Sabari JK, Sanborn RE, Mansfield AS, Hung JY, Boyer M, Popat S, Mourão Dias J, Felip E, Majem M, Gumus M, Kim SW, Ono A, Xie J, Bhattacharya A, Agrawal T, Shreeve SM, Knoblauch RE, Park K, Girard N; PAPILLON Investigators
N Engl J Med 2023 Nov 30;389(22):2039-2051. Epub 2023 Oct 21 doi: 10.1056/NEJMoa2306441. PMID: 37870976
Immunohistochemical profiling of receptor tyrosine kinases, MED12, and TGF-βRII of surgically resected small cell lung cancer, and the potential of c-kit as a prognostic marker.
Yokouchi H, Nishihara H, Harada T, Ishida T, Yamazaki S, Kikuchi H, Oizumi S, Uramoto H, Tanaka F, Harada M, Akie K, Sugaya F, Fujita Y, Takamura K, Kojima T, Higuchi M, Honjo O, Minami Y, Watanabe N, Goto A, Suzuki H, Dosaka-Akita H, Isobe H, Nishimura M, Munakata M
Oncotarget 2017 Jun 13;8(24):39711-39726. doi: 10.18632/oncotarget.14410. PMID: 28055980Free PMC Article
Heterogeneous nuclear ribonucleoproteins A1 and A2 modulate expression of Tid1 isoforms and EGFR signaling in non-small cell lung cancer.
Chen CY, Jan CI, Pi WC, Wang WL, Yang PC, Wang TH, Karni R, Wang TC
Oncotarget 2016 Mar 29;7(13):16760-72. doi: 10.18632/oncotarget.7606. PMID: 26919236Free PMC Article
Alterations in EGFR and related genes following neo-adjuvant chemotherapy in Chinese patients with non-small cell lung cancer.
Wang S, An T, Duan J, Zhang L, Wu M, Zhou Q, Chen J, Zhuo M, Yang L, Wang Y, Bai H, Wang J
PLoS One 2013;8(3):e51021. Epub 2013 Mar 8 doi: 10.1371/journal.pone.0051021. PMID: 23520442Free PMC Article

Diagnosis

The emerging role of noncoding RNAs in the EGFR signaling pathway in lung cancer.
Mohan S, Hakami MA, Dailah HG, Khalid A, Najmi A, Zoghebi K, Halawi MA
Pathol Res Pract 2024 Jan;253:155016. Epub 2023 Dec 5 doi: 10.1016/j.prp.2023.155016. PMID: 38070221
JMJD5 inhibits lung cancer progression by facilitating EGFR proteasomal degradation.
Shen J, Liu G, Qi H, Xiang X, Shao J
Cell Death Dis 2023 Oct 9;14(10):657. doi: 10.1038/s41419-023-06194-0. PMID: 37813845Free PMC Article
Celecoxib and Afatinib synergistic enhance radiotherapy sensitivity on human non-small cell lung cancer A549 cells.
Zhang P, Song E, Jiang M, Song Y
Int J Radiat Biol 2021;97(2):170-178. Epub 2020 Nov 12 doi: 10.1080/09553002.2021.1846817. PMID: 33164600
Twenty-One Novel EGFR Kinase Domain variants in Patients with Nonsmall Cell Lung Cancer.
Hasenahuer MA, Parisi G, Gautier M, Lazarowski A, Bramuglia GF, Fornasari MS
Ann Hum Genet 2015 Nov;79(6):385-93. Epub 2015 Sep 29 doi: 10.1111/ahg.12127. PMID: 26420346
Sulforaphane attenuates EGFR signaling in NSCLC cells.
Chen CY, Yu ZY, Chuang YS, Huang RM, Wang TC
J Biomed Sci 2015 Jun 3;22(1):38. doi: 10.1186/s12929-015-0139-x. PMID: 26036303Free PMC Article

Therapy

Amivantamab plus Lazertinib in Previously Untreated EGFR-Mutated Advanced NSCLC.
Cho BC, Lu S, Felip E, Spira AI, Girard N, Lee JS, Lee SH, Ostapenko Y, Danchaivijitr P, Liu B, Alip A, Korbenfeld E, Mourão Dias J, Besse B, Lee KH, Xiong H, How SH, Cheng Y, Chang GC, Yoshioka H, Yang JC, Thomas M, Nguyen D, Ou SI, Mukhedkar S, Prabhash K, D'Arcangelo M, Alatorre-Alexander J, Vázquez Limón JC, Alves S, Stroyakovskiy D, Peregudova M, Şendur MAN, Yazici O, Califano R, Gutiérrez Calderón V, de Marinis F, Passaro A, Kim SW, Gadgeel SM, Xie J, Sun T, Martinez M, Ennis M, Fennema E, Daksh M, Millington D, Leconte I, Iwasawa R, Lorenzini P, Baig M, Shah S, Bauml JM, Shreeve SM, Sethi S, Knoblauch RE, Hayashi H; MARIPOSA Investigators
N Engl J Med 2024 Oct 24;391(16):1486-1498. Epub 2024 Jun 26 doi: 10.1056/NEJMoa2403614. PMID: 38924756
Amivantamab plus Chemotherapy in NSCLC with EGFR Exon 20 Insertions.
Zhou C, Tang KJ, Cho BC, Liu B, Paz-Ares L, Cheng S, Kitazono S, Thiagarajan M, Goldman JW, Sabari JK, Sanborn RE, Mansfield AS, Hung JY, Boyer M, Popat S, Mourão Dias J, Felip E, Majem M, Gumus M, Kim SW, Ono A, Xie J, Bhattacharya A, Agrawal T, Shreeve SM, Knoblauch RE, Park K, Girard N; PAPILLON Investigators
N Engl J Med 2023 Nov 30;389(22):2039-2051. Epub 2023 Oct 21 doi: 10.1056/NEJMoa2306441. PMID: 37870976
Celecoxib and Afatinib synergistic enhance radiotherapy sensitivity on human non-small cell lung cancer A549 cells.
Zhang P, Song E, Jiang M, Song Y
Int J Radiat Biol 2021;97(2):170-178. Epub 2020 Nov 12 doi: 10.1080/09553002.2021.1846817. PMID: 33164600
TRIB3-EGFR interaction promotes lung cancer progression and defines a therapeutic target.
Yu JJ, Zhou DD, Yang XX, Cui B, Tan FW, Wang J, Li K, Shang S, Zhang C, Lv XX, Zhang XW, Liu SS, Yu JM, Wang F, Huang B, Hua F, Hu ZW
Nat Commun 2020 Jul 21;11(1):3660. doi: 10.1038/s41467-020-17385-0. PMID: 32694521Free PMC Article
Epidermal growth factor receptor (EGFR) involvement in epithelial-derived cancers and its current antibody-based immunotherapies.
London M, Gallo E
Cell Biol Int 2020 Jun;44(6):1267-1282. Epub 2020 Mar 17 doi: 10.1002/cbin.11340. PMID: 32162758

Prognosis

The emerging role of noncoding RNAs in the EGFR signaling pathway in lung cancer.
Mohan S, Hakami MA, Dailah HG, Khalid A, Najmi A, Zoghebi K, Halawi MA
Pathol Res Pract 2024 Jan;253:155016. Epub 2023 Dec 5 doi: 10.1016/j.prp.2023.155016. PMID: 38070221
TRIB3-EGFR interaction promotes lung cancer progression and defines a therapeutic target.
Yu JJ, Zhou DD, Yang XX, Cui B, Tan FW, Wang J, Li K, Shang S, Zhang C, Lv XX, Zhang XW, Liu SS, Yu JM, Wang F, Huang B, Hua F, Hu ZW
Nat Commun 2020 Jul 21;11(1):3660. doi: 10.1038/s41467-020-17385-0. PMID: 32694521Free PMC Article
Epidermal growth factor receptor (EGFR) involvement in epithelial-derived cancers and its current antibody-based immunotherapies.
London M, Gallo E
Cell Biol Int 2020 Jun;44(6):1267-1282. Epub 2020 Mar 17 doi: 10.1002/cbin.11340. PMID: 32162758
EGFR genomic alterations in cancer: prognostic and predictive values.
Bronte G, Terrasi M, Rizzo S, Sivestris N, Ficorella C, Cajozzo M, Di Gaudio F, Gulotta G, Siragusa S, Gebbia N, Russo A
Front Biosci (Elite Ed) 2011 Jun 1;3(3):879-87. doi: 10.2741/e296. PMID: 21622099
Combined assessment of EGFR pathway-related molecular markers and prognosis of NSCLC patients.
Galleges Ruiz MI, Floor K, Steinberg SM, Grünberg K, Thunnissen FB, Belien JA, Meijer GA, Peters GJ, Smit EF, Rodriguez JA, Giaccone G
Br J Cancer 2009 Jan 13;100(1):145-52. Epub 2008 Dec 2 doi: 10.1038/sj.bjc.6604781. PMID: 19050706Free PMC Article

Clinical prediction guides

Amivantamab plus Lazertinib in Previously Untreated EGFR-Mutated Advanced NSCLC.
Cho BC, Lu S, Felip E, Spira AI, Girard N, Lee JS, Lee SH, Ostapenko Y, Danchaivijitr P, Liu B, Alip A, Korbenfeld E, Mourão Dias J, Besse B, Lee KH, Xiong H, How SH, Cheng Y, Chang GC, Yoshioka H, Yang JC, Thomas M, Nguyen D, Ou SI, Mukhedkar S, Prabhash K, D'Arcangelo M, Alatorre-Alexander J, Vázquez Limón JC, Alves S, Stroyakovskiy D, Peregudova M, Şendur MAN, Yazici O, Califano R, Gutiérrez Calderón V, de Marinis F, Passaro A, Kim SW, Gadgeel SM, Xie J, Sun T, Martinez M, Ennis M, Fennema E, Daksh M, Millington D, Leconte I, Iwasawa R, Lorenzini P, Baig M, Shah S, Bauml JM, Shreeve SM, Sethi S, Knoblauch RE, Hayashi H; MARIPOSA Investigators
N Engl J Med 2024 Oct 24;391(16):1486-1498. Epub 2024 Jun 26 doi: 10.1056/NEJMoa2403614. PMID: 38924756
Insensitivity of oncogenic EGFR R776L mutation to EGFR inhibitors in lung cancer.
Wang Y, Hu C, Yu H, Hu J, Zhou Z, Fu N, Huang X, Kong F, Wang W, Liu J
Lung Cancer 2024 Mar;189:107495. Epub 2024 Jan 28 doi: 10.1016/j.lungcan.2024.107495. PMID: 38335691
The emerging role of noncoding RNAs in the EGFR signaling pathway in lung cancer.
Mohan S, Hakami MA, Dailah HG, Khalid A, Najmi A, Zoghebi K, Halawi MA
Pathol Res Pract 2024 Jan;253:155016. Epub 2023 Dec 5 doi: 10.1016/j.prp.2023.155016. PMID: 38070221
Molecular profiling of afatinib-resistant non-small cell lung cancer cells in vivo derived from mice.
Chung CT, Yeh KC, Lee CH, Chen YY, Ho PJ, Chang KY, Chen CH, Lai YK, Chen CT
Pharmacol Res 2020 Nov;161:105183. Epub 2020 Sep 5 doi: 10.1016/j.phrs.2020.105183. PMID: 32896579
EGFR genomic alterations in cancer: prognostic and predictive values.
Bronte G, Terrasi M, Rizzo S, Sivestris N, Ficorella C, Cajozzo M, Di Gaudio F, Gulotta G, Siragusa S, Gebbia N, Russo A
Front Biosci (Elite Ed) 2011 Jun 1;3(3):879-87. doi: 10.2741/e296. PMID: 21622099

Supplemental Content

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    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • Westwood et al., 2014
      Epidermal growth factor receptor tyrosine kinase (EGFR-TK) mutation testing in adults with locally advanced or metastatic non-small cell lung cancer: a systematic review and cost-effectiveness analysis.

    Consumer resources

    Reviews

    Related information

    • ClinVar
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      Related information in GTR
    • GTR(Clinical)
      Clinical tests in GTR
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