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Synostosis of joints

MedGen UID:
568615
Concept ID:
C0332790
Acquired Abnormality
Synonyms: Bony ankylosis; Fusion of joints; Osseous ankylosis; True ankylosis
SNOMED CT: Osseous ankylosis (70996008); Bony ankylosis (70996008); True ankylosis (70996008)
 
HPO: HP:0100240

Definition

The abnormal fusion of neighboring bones across a joint. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSynostosis of joints

Professional guidelines

PubMed

van Dijk CN, Longo UG, Loppini M, Florio P, Maltese L, Ciuffreda M, Denaro V
Knee Surg Sports Traumatol Arthrosc 2016 Apr;24(4):1200-16. Epub 2015 Dec 24 doi: 10.1007/s00167-015-3942-8. PMID: 26704800
Rammelt S, Obruba P
Eur J Trauma Emerg Surg 2015 Dec;41(6):601-14. Epub 2014 Nov 12 doi: 10.1007/s00068-014-0466-8. PMID: 26037997
Bergeron SG, Desy NM, Bernstein M, Harvey EJ
J Am Acad Orthop Surg 2012 Jul;20(7):450-8. doi: 10.5435/JAAOS-20-07-450. PMID: 22751164

Recent clinical studies

Etiology

Goovaerts S, Hoskens H, Eller RJ, Herrick N, Musolf AM, Justice CM, Yuan M, Naqvi S, Lee MK, Vandermeulen D, Szabo-Rogers HL, Romitti PA, Boyadjiev SA, Marazita ML, Shaffer JR, Shriver MD, Wysocka J, Walsh S, Weinberg SM, Claes P
Nat Commun 2023 Nov 16;14(1):7436. doi: 10.1038/s41467-023-43237-8. PMID: 37973980Free PMC Article
Klammer G, Espinosa N, Iselin LD
Foot Ankle Clin 2018 Sep;23(3):435-449. Epub 2018 Jun 28 doi: 10.1016/j.fcl.2018.04.011. PMID: 30097083
Dohn P, Khiami F, Rolland E, Goubier JN
Orthop Traumatol Surg Res 2012 Oct;98(6):709-14. Epub 2012 Sep 19 doi: 10.1016/j.otsr.2012.04.018. PMID: 23000035
Bergeron SG, Desy NM, Bernstein M, Harvey EJ
J Am Acad Orthop Surg 2012 Jul;20(7):450-8. doi: 10.5435/JAAOS-20-07-450. PMID: 22751164
Ogden JA, Watson HK, Bohne W
J Bone Joint Surg Am 1976 Jun;58(4):467-75. PMID: 818089

Diagnosis

Rutkowski PT, Samora JB
J Am Acad Orthop Surg 2021 Jul 1;29(13):563-570. doi: 10.5435/JAAOS-D-20-01133. PMID: 33826558
Zhang J, Li J, Saucier JB, Feng Y, Jiang Y, Sinson J, McCombs AK, Schmitt ES, Peacock S, Chen S, Dai H, Ge X, Wang G, Shaw CA, Mei H, Breman A, Xia F, Yang Y, Purgason A, Pourpak A, Chen Z, Wang X, Wang Y, Kulkarni S, Choy KW, Wapner RJ, Van den Veyver IB, Beaudet A, Parmar S, Wong LJ, Eng CM
Nat Med 2019 Mar;25(3):439-447. Epub 2019 Jan 28 doi: 10.1038/s41591-018-0334-x. PMID: 30692697
Klammer G, Espinosa N, Iselin LD
Foot Ankle Clin 2018 Sep;23(3):435-449. Epub 2018 Jun 28 doi: 10.1016/j.fcl.2018.04.011. PMID: 30097083
Swensen SJ, Otsuka NY
Foot Ankle Clin 2015 Dec;20(4):669-79. doi: 10.1016/j.fcl.2015.08.001. PMID: 26589085
Zaw H, Calder JD
Foot Ankle Clin 2010 Jun;15(2):349-64. doi: 10.1016/j.fcl.2010.02.003. PMID: 20534361

Therapy

Della Rosa N, Bertozzi N, Annoscia P, Adani R
Plast Reconstr Surg 2022 Dec 1;150(6):1283e-1292e. Epub 2022 Sep 20 doi: 10.1097/PRS.0000000000009736. PMID: 36126203
Tohma Y, Takeuchi R, Tanaka Y
Eur J Orthop Surg Traumatol 2019 Jan;29(1):131-137. Epub 2018 Aug 17 doi: 10.1007/s00590-018-2286-8. PMID: 30120535
Jiménez-Díaz V, Auñón-Martín I, Olaya-González C, Aroca-Peinado M, Cecilia-López D, Caba-Doussoux P
Eur J Orthop Surg Traumatol 2017 Jul;27(5):607-615. Epub 2016 Oct 13 doi: 10.1007/s00590-016-1866-8. PMID: 27738769
Bonasia DE, Phisitkul P, Amendola A
Foot Ankle Clin 2015 Mar;20(1):81-91. Epub 2014 Dec 15 doi: 10.1016/j.fcl.2014.10.006. PMID: 25726485
van den Bekerom MP, de Leeuw PA, van Dijk CN
Injury 2009 Nov;40(11):1137-42. Epub 2009 Jun 12 doi: 10.1016/j.injury.2009.03.011. PMID: 19524232

Prognosis

Wang T, Qi H, Rong K, Zhang S, Bao S, Cheng T, Teng J
Acta Radiol 2021 Jul;62(7):897-903. Epub 2020 Aug 5 doi: 10.1177/0284185120944911. PMID: 32757638
Zhang J, Li J, Saucier JB, Feng Y, Jiang Y, Sinson J, McCombs AK, Schmitt ES, Peacock S, Chen S, Dai H, Ge X, Wang G, Shaw CA, Mei H, Breman A, Xia F, Yang Y, Purgason A, Pourpak A, Chen Z, Wang X, Wang Y, Kulkarni S, Choy KW, Wapner RJ, Van den Veyver IB, Beaudet A, Parmar S, Wong LJ, Eng CM
Nat Med 2019 Mar;25(3):439-447. Epub 2019 Jan 28 doi: 10.1038/s41591-018-0334-x. PMID: 30692697
Mahjoub S, Lahmar AA, Miladi M, Abdelkafi M, Mbarek M
Joint Bone Spine 2018 May;85(3):371. Epub 2017 Jul 13 doi: 10.1016/j.jbspin.2017.07.001. PMID: 28713069
Rammelt S, Obruba P
Eur J Trauma Emerg Surg 2015 Dec;41(6):601-14. Epub 2014 Nov 12 doi: 10.1007/s00068-014-0466-8. PMID: 26037997
Ogden JA, Watson HK, Bohne W
J Bone Joint Surg Am 1976 Jun;58(4):467-75. PMID: 818089

Clinical prediction guides

Silveira KC, Fonseca IC, Oborn C, Wengryn P, Ghafoor S, Beke A, Dreseris ES, Wong C, Iacovone A, Soltys CL, Babul-Hirji R, Artigalas O, Antolini-Tavares A, Gingras AC, Campos E, Cavalcanti DP, Kannu P
Hum Genet 2023 Nov;142(11):1571-1586. Epub 2023 Sep 27 doi: 10.1007/s00439-023-02598-2. PMID: 37755482Free PMC Article
Shevchuk VI, Bezsmertnyi YO, Jiang Y, Bezsmertna HV, Dovgalyuk TV
Med Glas (Zenica) 2021 Aug 1;18(2):479-486. doi: 10.17392/1374-21. PMID: 34212707
Rutkowski PT, Samora JB
J Am Acad Orthop Surg 2021 Jul 1;29(13):563-570. doi: 10.5435/JAAOS-D-20-01133. PMID: 33826558
Zhang J, Li J, Saucier JB, Feng Y, Jiang Y, Sinson J, McCombs AK, Schmitt ES, Peacock S, Chen S, Dai H, Ge X, Wang G, Shaw CA, Mei H, Breman A, Xia F, Yang Y, Purgason A, Pourpak A, Chen Z, Wang X, Wang Y, Kulkarni S, Choy KW, Wapner RJ, Van den Veyver IB, Beaudet A, Parmar S, Wong LJ, Eng CM
Nat Med 2019 Mar;25(3):439-447. Epub 2019 Jan 28 doi: 10.1038/s41591-018-0334-x. PMID: 30692697
Ogden JA, Watson HK, Bohne W
J Bone Joint Surg Am 1976 Jun;58(4):467-75. PMID: 818089

Recent systematic reviews

van Dijk CN, Longo UG, Loppini M, Florio P, Maltese L, Ciuffreda M, Denaro V
Knee Surg Sports Traumatol Arthrosc 2016 Apr;24(4):1200-16. Epub 2015 Dec 24 doi: 10.1007/s00167-015-3942-8. PMID: 26704800

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