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Decreased circulating antibody concentration

MedGen UID:
892481
Concept ID:
C4048270
Finding
Synonym: Decreased antibody level in blood
 
HPO: HP:0004313

Definition

An abnormally decreased level of immunoglobulin in blood. [from HPO]

Conditions with this feature

Professional guidelines

PubMed

Fava A, Wagner CA, Guthridge CJ, Kheir J, Macwana S, DeJager W, Gross T, Izmirly P, Belmont HM, Diamond B, Davidson A, Utz PJ, Weisman MH, Magder LS; Accelerating Medicines Partnership Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Network, Guthridge JM, Petri M, Buyon J, James JA
Arthritis Rheumatol 2024 Nov;76(11):1611-1622. Epub 2024 Aug 9 doi: 10.1002/art.42941. PMID: 38962936Free PMC Article
Bax HJ, Chauhan J, Stavraka C, Santaolalla A, Osborn G, Khiabany A, Grandits M, López-Abente J, Palhares LCGF, Chan Wah Hak C, Robinson A, Pope A, Woodman N, Naceur-Lombardelli C, Malas S, Coumbe JEM, Nakamura M, Laddach R, Mele S, Crescioli S, Black AM, Lombardi S, Canevari S, Figini M, Sayasneh A, Tsoka S, FitzGerald K, Gillett C, Pinder S, Van Hemelrijck M, Kristeleit R, Ghosh S, Montes A, Spicer J, Karagiannis SN, Josephs DH
Br J Cancer 2023 Jan;128(2):342-353. Epub 2022 Nov 19 doi: 10.1038/s41416-022-02031-x. PMID: 36402875Free PMC Article
Benschop RJ, Chow CK, Tian Y, Nelson J, Barmettler B, Atwell S, Clawson D, Chai Q, Jones B, Fitchett J, Torgerson S, Ji Y, Bina H, Hu N, Ghanem M, Manetta J, Wroblewski VJ, Lu J, Allan BW
MAbs 2019 Aug/Sep;11(6):1175-1190. Epub 2019 Jun 10 doi: 10.1080/19420862.2019.1624463. PMID: 31181988Free PMC Article

Recent clinical studies

Etiology

Bredewold OW, van Oeveren-Rietdijk AM, Florijn B, Rotmans JI, de Fijter JW, van Kooten C, van Zonneveld AJ, de Boer HC
Transpl Immunol 2024 Feb;82:101976. Epub 2024 Jan 8 doi: 10.1016/j.trim.2023.101976. PMID: 38199271
Biondi B, Cappola AR, Cooper DS
JAMA 2019 Jul 9;322(2):153-160. doi: 10.1001/jama.2019.9052. PMID: 31287527
Kishnani PS, Rockman-Greenberg C, Rauch F, Bhatti MT, Moseley S, Denker AE, Watsky E, Whyte MP
Bone 2019 Apr;121:149-162. Epub 2018 Dec 18 doi: 10.1016/j.bone.2018.12.011. PMID: 30576866
Interleukin-6 Receptor Mendelian Randomisation Analysis (IL6R MR) Consortium, Swerdlow DI, Holmes MV, Kuchenbaecker KB, Engmann JE, Shah T, Sofat R, Guo Y, Chung C, Peasey A, Pfister R, Mooijaart SP, Ireland HA, Leusink M, Langenberg C, Li KW, Palmen J, Howard P, Cooper JA, Drenos F, Hardy J, Nalls MA, Li YR, Lowe G, Stewart M, Bielinski SJ, Peto J, Timpson NJ, Gallacher J, Dunlop M, Houlston R, Tomlinson I, Tzoulaki I, Luan J, Boer JM, Forouhi NG, Onland-Moret NC, van der Schouw YT, Schnabel RB, Hubacek JA, Kubinova R, Baceviciene M, Tamosiunas A, Pajak A, Topor-Madry R, Malyutina S, Baldassarre D, Sennblad B, Tremoli E, de Faire U, Ferrucci L, Bandenelli S, Tanaka T, Meschia JF, Singleton A, Navis G, Mateo Leach I, Bakker SJ, Gansevoort RT, Ford I, Epstein SE, Burnett MS, Devaney JM, Jukema JW, Westendorp RG, Jan de Borst G, van der Graaf Y, de Jong PA, Mailand-van der Zee AH, Klungel OH, de Boer A, Doevendans PA, Stephens JW, Eaton CB, Robinson JG, Manson JE, Fowkes FG, Frayling TM, Price JF, Whincup PH, Morris RW, Lawlor DA, Smith GD, Ben-Shlomo Y, Redline S, Lange LA, Kumari M, Wareham NJ, Verschuren WM, Benjamin EJ, Whittaker JC, Hamsten A, Dudbridge F, Delaney JA, Wong A, Kuh D, Hardy R, Castillo BA, Connolly JJ, van der Harst P, Brunner EJ, Marmot MG, Wassel CL, Humphries SE, Talmud PJ, Kivimaki M, Asselbergs FW, Voevoda M, Bobak M, Pikhart H, Wilson JG, Hakonarson H, Reiner AP, Keating BJ, Sattar N, Hingorani AD, Casas JP
Lancet 2012 Mar 31;379(9822):1214-24. Epub 2012 Mar 14 doi: 10.1016/S0140-6736(12)60110-X. PMID: 22421340Free PMC Article
Finkelstein Y, Aks SE, Hutson JR, Juurlink DN, Nguyen P, Dubnov-Raz G, Pollak U, Koren G, Bentur Y
Clin Toxicol (Phila) 2010 Jun;48(5):407-14. doi: 10.3109/15563650.2010.495348. PMID: 20586571

Diagnosis

Altarejos JY, Pangilinan J, Podgrabinska S, Akinci B, Foss-Freitas M, Neidert AH, Ray Y, Zheng W, Kim S, Kamat V, Huang M, Min S, Mastaitis J, Dominguez-Gutierrez G, Kim JH, Stevis P, Huang T, Zambrowicz B, Olson WC, Godin S, Bradley E, Gewitz AD, Baker M, Hench R, Davenport MS, Chenevert TL, DiPaola F, Yancopoulos GD, Murphy AJ, Herman GA, Musser BJ, Dansky H, Harp J, Gromada J, Sleeman MW, Oral EA, Olenchock BA
Sci Transl Med 2023 Nov 22;15(723):eadd4897. doi: 10.1126/scitranslmed.add4897. PMID: 37992152
Avery RL, Castellarin AA, Steinle NC, Dhoot DS, Pieramici DJ, See R, Couvillion S, Nasir MA, Rabena MD, Maia M, Van Everen S, Le K, Hanley WD
Retina 2017 Oct;37(10):1847-1858. doi: 10.1097/IAE.0000000000001493. PMID: 28106709Free PMC Article
Finkelstein Y, Aks SE, Hutson JR, Juurlink DN, Nguyen P, Dubnov-Raz G, Pollak U, Koren G, Bentur Y
Clin Toxicol (Phila) 2010 Jun;48(5):407-14. doi: 10.3109/15563650.2010.495348. PMID: 20586571
van Genderen PJ, Michiels JJ
Baillieres Clin Haematol 1998 Jun;11(2):319-30. doi: 10.1016/s0950-3536(98)80051-6. PMID: 10097810
Gurka G, Rocklin RE
JAMA 1987 Nov 27;258(20):2983-7. PMID: 3312681

Therapy

Vandestienne M, Zhang Y, Santos-Zas I, Al-Rifai R, Joffre J, Giraud A, Laurans L, Esposito B, Pinet F, Bruneval P, Raffort J, Lareyre F, Vilar J, Boufenzer A, Guyonnet L, Guerin C, Clauser E, Silvestre JS, Lang S, Soulat-Dufour L, Tedgui A, Mallat Z, Taleb S, Boissonnas A, Derive M, Chinetti G, Ait-Oufella H
J Clin Invest 2021 Jan 19;131(2) doi: 10.1172/JCI142468. PMID: 33258804Free PMC Article
Biondi B, Cappola AR, Cooper DS
JAMA 2019 Jul 9;322(2):153-160. doi: 10.1001/jama.2019.9052. PMID: 31287527
Furie R, Werth VP, Merola JF, Stevenson L, Reynolds TL, Naik H, Wang W, Christmann R, Gardet A, Pellerin A, Hamann S, Auluck P, Barbey C, Gulati P, Rabah D, Franchimont N
J Clin Invest 2019 Mar 1;129(3):1359-1371. Epub 2019 Feb 18 doi: 10.1172/JCI124466. PMID: 30645203Free PMC Article
Kishnani PS, Rockman-Greenberg C, Rauch F, Bhatti MT, Moseley S, Denker AE, Watsky E, Whyte MP
Bone 2019 Apr;121:149-162. Epub 2018 Dec 18 doi: 10.1016/j.bone.2018.12.011. PMID: 30576866
Finkelstein Y, Aks SE, Hutson JR, Juurlink DN, Nguyen P, Dubnov-Raz G, Pollak U, Koren G, Bentur Y
Clin Toxicol (Phila) 2010 Jun;48(5):407-14. doi: 10.3109/15563650.2010.495348. PMID: 20586571

Prognosis

Fava A, Wagner CA, Guthridge CJ, Kheir J, Macwana S, DeJager W, Gross T, Izmirly P, Belmont HM, Diamond B, Davidson A, Utz PJ, Weisman MH, Magder LS; Accelerating Medicines Partnership Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Network, Guthridge JM, Petri M, Buyon J, James JA
Arthritis Rheumatol 2024 Nov;76(11):1611-1622. Epub 2024 Aug 9 doi: 10.1002/art.42941. PMID: 38962936Free PMC Article
Villani S, Zanotta N, Ambrogi F, Comar M, Franciotta D, Dolci M, Cason C, Ticozzi R, Ferrante P, Delbue S
J Neuroimmunol 2017 Sep 15;310:91-96. Epub 2017 Jul 1 doi: 10.1016/j.jneuroim.2017.06.012. PMID: 28778452
Avery RL, Castellarin AA, Steinle NC, Dhoot DS, Pieramici DJ, See R, Couvillion S, Nasir MA, Rabena MD, Maia M, Van Everen S, Le K, Hanley WD
Retina 2017 Oct;37(10):1847-1858. doi: 10.1097/IAE.0000000000001493. PMID: 28106709Free PMC Article
Finkelstein Y, Aks SE, Hutson JR, Juurlink DN, Nguyen P, Dubnov-Raz G, Pollak U, Koren G, Bentur Y
Clin Toxicol (Phila) 2010 Jun;48(5):407-14. doi: 10.3109/15563650.2010.495348. PMID: 20586571
Nilsson IM, Freiburghaus C
Adv Exp Med Biol 1995;386:175-84. doi: 10.1007/978-1-4613-0331-2_16. PMID: 8851026

Clinical prediction guides

Bredewold OW, van Oeveren-Rietdijk AM, Florijn B, Rotmans JI, de Fijter JW, van Kooten C, van Zonneveld AJ, de Boer HC
Transpl Immunol 2024 Feb;82:101976. Epub 2024 Jan 8 doi: 10.1016/j.trim.2023.101976. PMID: 38199271
Perugino CA, Wallace ZS, Zack DJ, Quinn SM, Poma A, Fernandes AD, Foster P, DeMattos S, Burington B, Liu H, Allard-Chamard H, Smith N, Kai X, Xing K, Pillai S, Stone JH
Lancet Rheumatol 2023 Aug;5(8):e442-e450. Epub 2023 Jul 24 doi: 10.1016/S2665-9913(23)00157-1. PMID: 38251576
Biondi B, Cappola AR, Cooper DS
JAMA 2019 Jul 9;322(2):153-160. doi: 10.1001/jama.2019.9052. PMID: 31287527
Furie R, Werth VP, Merola JF, Stevenson L, Reynolds TL, Naik H, Wang W, Christmann R, Gardet A, Pellerin A, Hamann S, Auluck P, Barbey C, Gulati P, Rabah D, Franchimont N
J Clin Invest 2019 Mar 1;129(3):1359-1371. Epub 2019 Feb 18 doi: 10.1172/JCI124466. PMID: 30645203Free PMC Article
Kishnani PS, Rockman-Greenberg C, Rauch F, Bhatti MT, Moseley S, Denker AE, Watsky E, Whyte MP
Bone 2019 Apr;121:149-162. Epub 2018 Dec 18 doi: 10.1016/j.bone.2018.12.011. PMID: 30576866

Recent systematic reviews

Jamialahmadi T, Baratzadeh F, Reiner Ž, Mannarino MR, Cardenia V, Simental-Mendía LE, Pirro M, Watts GF, Sahebkar A
Oxid Med Cell Longev 2022;2022:7850659. Epub 2022 Aug 1 doi: 10.1155/2022/7850659. PMID: 35958018Free PMC Article
Finkelstein Y, Aks SE, Hutson JR, Juurlink DN, Nguyen P, Dubnov-Raz G, Pollak U, Koren G, Bentur Y
Clin Toxicol (Phila) 2010 Jun;48(5):407-14. doi: 10.3109/15563650.2010.495348. PMID: 20586571
Morselli-Labate AM, Pezzilli R
J Gastroenterol Hepatol 2009 Jan;24(1):15-36. Epub 2008 Dec 2 doi: 10.1111/j.1440-1746.2008.05676.x. PMID: 19067780
Baccarelli A, Mocarelli P, Patterson DG Jr, Bonzini M, Pesatori AC, Caporaso N, Landi MT
Environ Health Perspect 2002 Dec;110(12):1169-73. doi: 10.1289/ehp.021101169. PMID: 12460794Free PMC Article

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