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Hepatic failure

MedGen UID:
88444
Concept ID:
C0085605
Disease or Syndrome
Synonym: Liver failure
SNOMED CT: Liver failure (59927004); Hepatic failure (59927004); Liver function failure (59927004); Liver decompensation (59927004)
 
HPO: HP:0001399
Monarch Initiative: MONDO:0100192

Definition

A disorder characterized by the inability of the liver to metabolize chemicals in the body. Causes include cirrhosis and drug-induced hepatotoxicity. Signs and symptoms include jaundice and encephalopathy. Laboratory test results reveal abnormal plasma levels of ammonia, bilirubin, lactic dehydrogenase, and alkaline phosphatase. [from NCI]

Conditions with this feature

Professional guidelines

PubMed

Overton E, Tobes D, Lee A
Best Pract Res Clin Anaesthesiol 2022 May;36(1):107-121. Epub 2022 Feb 10 doi: 10.1016/j.bpa.2022.02.003. PMID: 35659948
Hasan I, Rashid T, Chirila RM, Ghali P, Wadei HM
Rom J Intern Med 2021 Sep 1;59(3):227-261. Epub 2021 Aug 26 doi: 10.2478/rjim-2021-0006. PMID: 33544554
Freeman WD
Continuum (Minneap Minn) 2015 Oct;21(5 Neurocritical Care):1299-323. doi: 10.1212/CON.0000000000000235. PMID: 26426232

Recent clinical studies

Etiology

Marani M, Madan V, Le TK, Deng J, Lee KK, Ma EZ, Kwatra SG
Genes (Basel) 2024 Jan 23;15(2) doi: 10.3390/genes15020146. PMID: 38397136Free PMC Article
Brentjens TE, Chadha R
Anesthesiol Clin 2016 Dec;34(4):645-658. doi: 10.1016/j.anclin.2016.06.002. PMID: 27816125
Datar S, Wijdicks EF
Handb Clin Neurol 2014;120:645-59. doi: 10.1016/B978-0-7020-4087-0.00044-9. PMID: 24365344
Abbas Z, Afzal R
Antivir Ther 2014;19(2):125-31. Epub 2013 Nov 5 doi: 10.3851/IMP2705. PMID: 24192696
Riely CA
Am J Med 1994 Jan 17;96(1A):18S-22S. doi: 10.1016/0002-9343(94)90185-6. PMID: 8109583

Diagnosis

Kim WJ, Park C, Sarraf K
Br J Hosp Med (Lond) 2023 Jan 2;84(1):1-5. Epub 2023 Jan 16 doi: 10.12968/hmed.2022.0362. PMID: 36708343
Grek A, Arasi L
AACN Adv Crit Care 2016 Oct;27(4):420-429. doi: 10.4037/aacnacc2016324. PMID: 27959298
Bhalla A, Suri V, Singh V
J Postgrad Med 2006 Oct-Dec;52(4):315-20. PMID: 17102560
Bernstein D, Tripodi J
Crit Care Clin 1998 Apr;14(2):181-97. doi: 10.1016/s0749-0704(05)70391-2. PMID: 9561813
Gammal SH, Jones EA
Med Clin North Am 1989 Jul;73(4):793-813. doi: 10.1016/s0025-7125(16)30639-3. PMID: 2657263

Therapy

Kelley RK, Rimassa L, Cheng AL, Kaseb A, Qin S, Zhu AX, Chan SL, Melkadze T, Sukeepaisarnjaroen W, Breder V, Verset G, Gane E, Borbath I, Rangel JDG, Ryoo BY, Makharadze T, Merle P, Benzaghou F, Banerjee K, Hazra S, Fawcett J, Yau T
Lancet Oncol 2022 Aug;23(8):995-1008. Epub 2022 Jul 4 doi: 10.1016/S1470-2045(22)00326-6. PMID: 35798016
Garin E, Tselikas L, Guiu B, Chalaye J, Edeline J, de Baere T, Assenat E, Tacher V, Robert C, Terroir-Cassou-Mounat M, Mariano-Goulart D, Amaddeo G, Palard X, Hollebecque A, Kafrouni M, Regnault H, Boudjema K, Grimaldi S, Fourcade M, Kobeiter H, Vibert E, Le Sourd S, Piron L, Sommacale D, Laffont S, Campillo-Gimenez B, Rolland Y; DOSISPHERE-01 Study Group
Lancet Gastroenterol Hepatol 2021 Jan;6(1):17-29. Epub 2020 Nov 7 doi: 10.1016/S2468-1253(20)30290-9. PMID: 33166497
Chiew AL, Gluud C, Brok J, Buckley NA
Cochrane Database Syst Rev 2018 Feb 23;2(2):CD003328. doi: 10.1002/14651858.CD003328.pub3. PMID: 29473717Free PMC Article
Lohse AW, Mieli-Vergani G
J Hepatol 2011 Jul;55(1):171-82. Epub 2010 Dec 15 doi: 10.1016/j.jhep.2010.12.012. PMID: 21167232
Davison AM
Nephrol Dial Transplant 1996;11 Suppl 8:24-31. doi: 10.1093/ndt/11.supp8.24. PMID: 9044337

Prognosis

Wu Z, Chen Q, Qu L, Li M, Wang L, Mir MC, Carbonara U, Pandolfo SD, Black PC, Paul AK, Di Lorenzo G, Porpiglia F, Mari A, Necchi A, Rouprêt M, Psutka SP, Autorino R
Eur Urol 2022 Apr;81(4):414-425. Epub 2022 Jan 31 doi: 10.1016/j.eururo.2022.01.028. PMID: 35101302
Schmid P, Rugo HS, Adams S, Schneeweiss A, Barrios CH, Iwata H, Diéras V, Henschel V, Molinero L, Chui SY, Maiya V, Husain A, Winer EP, Loi S, Emens LA; IMpassion130 Investigators
Lancet Oncol 2020 Jan;21(1):44-59. Epub 2019 Nov 27 doi: 10.1016/S1470-2045(19)30689-8. PMID: 31786121
Nelson DB, Byrne JJ, Cunningham FG
Clin Obstet Gynecol 2020 Mar;63(1):152-164. doi: 10.1097/GRF.0000000000000494. PMID: 31725416
Shen T, Liu Y, Shang J, Xie Q, Li J, Yan M, Xu J, Niu J, Liu J, Watkins PB, Aithal GP, Andrade RJ, Dou X, Yao L, Lv F, Wang Q, Li Y, Zhou X, Zhang Y, Zong P, Wan B, Zou Z, Yang D, Nie Y, Li D, Wang Y, Han X, Zhuang H, Mao Y, Chen C
Gastroenterology 2019 Jun;156(8):2230-2241.e11. Epub 2019 Feb 8 doi: 10.1053/j.gastro.2019.02.002. PMID: 30742832
Kelly DA
Indian J Pediatr 1999;66(1 Suppl):S104-9. PMID: 11132456

Clinical prediction guides

van Gerven NM, de Boer YS, Mulder CJ, van Nieuwkerk CM, Bouma G
World J Gastroenterol 2016 May 21;22(19):4651-61. doi: 10.3748/wjg.v22.i19.4651. PMID: 27217697Free PMC Article
Zhu JY, Han Y
J Dig Dis 2015 Sep;16(9):483-8. doi: 10.1111/1751-2980.12285. PMID: 26332151
Wang X, Sarin SK, Ning Q
Hepatol Int 2015 Jul;9(3):360-5. Epub 2015 May 28 doi: 10.1007/s12072-015-9637-x. PMID: 26016465
Loudianos G, Lepori MB, Mameli E, Dessì V, Zappu A
Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2014;35(1):93-8. PMID: 24798599
O'Leary JG, Lepe R, Davis GL
Gastroenterology 2008 May;134(6):1764-76. doi: 10.1053/j.gastro.2008.02.028. PMID: 18471553

Recent systematic reviews

Kovács E, Maimeri N, Orlando F, Morselli F, Pallanch O, Fedrizzi M, Gál J, Székely A
Physiol Int 2023 Sep 5;110(3):211-226. Epub 2023 Aug 28 doi: 10.1556/2060.2023.00211. PMID: 37639341
Yin S, Zhang F, Wu J, Lin T, Wang X
PLoS Med 2023 Mar;20(3):e1004196. Epub 2023 Mar 15 doi: 10.1371/journal.pmed.1004196. PMID: 36920988Free PMC Article
El Jamaly H, Eslick GD, Weltman M
Aliment Pharmacol Ther 2022 Oct;56(7):1104-1118. Epub 2022 Aug 17 doi: 10.1111/apt.17155. PMID: 35975904
Wu Z, Chen Q, Qu L, Li M, Wang L, Mir MC, Carbonara U, Pandolfo SD, Black PC, Paul AK, Di Lorenzo G, Porpiglia F, Mari A, Necchi A, Rouprêt M, Psutka SP, Autorino R
Eur Urol 2022 Apr;81(4):414-425. Epub 2022 Jan 31 doi: 10.1016/j.eururo.2022.01.028. PMID: 35101302
Chiew AL, Gluud C, Brok J, Buckley NA
Cochrane Database Syst Rev 2018 Feb 23;2(2):CD003328. doi: 10.1002/14651858.CD003328.pub3. PMID: 29473717Free PMC Article

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