svila supervillin a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: svilaprovided by ZNC
Official Full Name: supervillin aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-990706-5
See related: Ensembl:ENSDARG00000055075 AllianceGenome:ZFIN:ZDB-GENE-990706-5
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: svil; sb:cb867; wu:fd05a09
Summary: Predicted to enable actin filament binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in actin filament severing; actin polymerization or depolymerization; and barbed-end actin filament capping. Predicted to act upstream of or within cytoskeleton organization. Predicted to be active in actin cytoskeleton and cytoplasm. Is expressed in several structures, including adaxial cell; cardiovascular system; musculature system; optic vesicle; and sensory system. Human ortholog(s) of this gene implicated in myofibrillar myopathy 10. Orthologous to human SVIL (supervillin). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 45

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (23812531..23932576)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (23691312..23811357)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

z48446 (e-PCR), detects polymorphism
- UniSTS:238612

fd05a09.x1 (e-PCR)
- UniSTS:204053

AA555521 (e-PCR)
- UniSTS:206911

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cytoskeleton organization	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: supervillin a

Names: zmp:0000000648

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001035261.2 → NP_001030338.2 supervillin a isoform 2

Status: VALIDATED

Source sequence(s)

CU914155, DQ227765

UniProtKB/TrEMBL

A0A8M1N7Y6, F1Q6K8, Q38HW9

Related

ENSDARP00000066330.4, ENSDART00000066331.7

Conserved Domains (6) summary

cd11280
Location:1108 → 1208

gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins

cd11288
Location:1424 → 1527

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:987 → 1083

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:1291 → 1402

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

pfam02209
Location:1722 → 1763

VHP; Villin headpiece domain

cl15697
Location:1544 → 1665

ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
NM_001430943.1 → NP_001417872.1 supervillin a isoform 1

Status: VALIDATED

Source sequence(s)

BX005400, CU914155

UniProtKB/TrEMBL

A0A8M9QII8

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007123.7 Reference GRCz11 Primary Assembly

Range

23812531..23932576

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021480012.2 → XP_021335687.1 supervillin a isoform X1

UniProtKB/TrEMBL

A0A8M9PW23

Conserved Domains (6) summary

cd11280
Location:1586 → 1686

gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins

cd11288
Location:1902 → 2005

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:1465 → 1561

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:1769 → 1880

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

pfam02209
Location:2200 → 2241

VHP; Villin headpiece domain

cl15697
Location:2022 → 2143

ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
XM_021480014.2 → XP_021335689.1 supervillin a isoform X3

UniProtKB/TrEMBL

A0A8M9QE30

Conserved Domains (6) summary

cd11280
Location:1553 → 1653

gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins

cd11288
Location:1869 → 1972

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:1432 → 1528

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:1736 → 1847

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

pfam02209
Location:2167 → 2208

VHP; Villin headpiece domain

cl15697
Location:1989 → 2110

ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
XM_021480013.2 → XP_021335688.1 supervillin a isoform X2

UniProtKB/TrEMBL

A0A8M9Q864

Conserved Domains (6) summary

cd11280
Location:1584 → 1684

gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins

cd11288
Location:1900 → 2003

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:1463 → 1559

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:1767 → 1878

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

pfam02209
Location:2198 → 2239

VHP; Villin headpiece domain

cl15697
Location:2020 → 2141

ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
XM_021480015.2 → XP_021335690.1 supervillin a isoform X4

UniProtKB/TrEMBL

A0A8M9QMC6, Q38HW9

Conserved Domains (6) summary

cd11280
Location:1264 → 1364

gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins

cd11288
Location:1580 → 1683

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:1143 → 1239

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:1447 → 1558

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

pfam02209
Location:1878 → 1919

VHP; Villin headpiece domain

cl15697
Location:1700 → 1821

ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
XM_021480016.2 → XP_021335691.1 supervillin a isoform X5

UniProtKB/TrEMBL

A0A8M9QIJ4, Q38HW9

Conserved Domains (6) summary

cd11280
Location:1192 → 1292

gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins

cd11288
Location:1508 → 1611

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:1071 → 1167

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:1375 → 1486

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

pfam02209
Location:1806 → 1847

VHP; Villin headpiece domain

cl15697
Location:1628 → 1749

ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
XM_068224487.1 → XP_068080588.1 supervillin a isoform X6