TGFbR signaling in squamous epithelial cells plays a fundamental role in controlling tissue specific allergic inflammation - - GEO DataSets

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TGFbR signaling in squamous epithelial cells plays a fundamental role in controlling tissue specific allergic inflammation

(Submitter supplied) Allergic diseases are becoming a global health crisis. Individuals harboring loss-of-function variants in transforming growth factor beta receptor (TGFbR) have an increased prevalence of allergic disease, but the mechanisms responsible are poorly understood. We demonstrate that mice harboring a variant identified in patients spontaneously develop disease that clinically, immunologically, histologically, and transcriptionally recapitulates eosinophilic esophagitis, a condition characterized by allergic inflammation in the esophagus. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
18 Samples

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Accession:: GSE193756

ID:: 200193756

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