GPL16570[RGSE] - GEO DataSets

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Select item 2002220501.

ITK-SYK induced peripheral T-cell lymphomas induce granulocyte activation

(Submitter supplied) ITK-SYK or control vector were overexpressed in Balb/c mice and ITK-SYK mice developed peripheral T-cell lymphomas within 5 weeks. CD4+ T-cells and granulocytes were harvested from the spleens of control and ITK-SYK mice and compared.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL16570
12 Samples

Download data: CEL

Series

Accession:: GSE222050

ID:: 200222050

PubMed Analyze with GEO2R

Select item 2002325212.

Expression data from pairwise non-tumor and tumor liver of -MYC and C-MYC/REG3A transgenic mice

(Submitter supplied) Antimicrobial proteins of the REG3 family represent, like a wide variety of C-type lectins to which they belong, the first line of protection against infections and transformed cells. Their expression is inducible, particularly in response to inflammation, making their role in cancer biology less clear and controversial, as an immune-inflammation background may pre-exist or co-exist. We show that REG3A presents a suppressive role of REG3A in hepatocellular carcinoma (HCC) in a mouse models of HCC driven by c-MYC. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL16570
16 Samples

Download data: CEL

Series

Accession:: GSE232521

ID:: 200232521

Analyze with GEO2R

Select item 2002844273.

Expression data from WT and Neu1 deficient 1 mo and 5 mo hippocampi

(Submitter supplied) Microarray data was used to assess progressive upregulation of genes during course of disease in Neu1 deficient mice and use for GSEA studies to assess upregulated pathways. Top upregulated genes often belonged to the myeloid lineage. Data was used to guide assessment of the neuroinflammatory response that occurs in Neu1 deficient hippocampi.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL16570
12 Samples

Download data: CEL

Series

Accession:: GSE284427

ID:: 200284427

Analyze with GEO2R

Select item 2001375344.

Transcriptome profiling of vascular fragments 3h and 24h post MCAO in imatinib and PBS treated mice

(Submitter supplied) We isolated vascular fragments, representing the BBB, from the ipsilateral hemisphere of imatinib and PBS treated mice 3h and 24h post MCAO induction.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL16570
11 Samples

Download data: CEL, XLSX

Series

Accession:: GSE137534

ID:: 200137534

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Select item 2002713385.

Regulatory T cells crosstalk with tumor and endothelium through lymphotoxin signaling [array]

(Submitter supplied) Tregs with multifaceted functions suppress anti-tumor immunity by signaling surrounding cells. Tregs use the surface LTa1b2 to preferentially stimulate LTbR nonclassical NFkB signaling on both tumor and LECs to accelerate tumor growth and metastasis. Selectively targeting LTβR nonclassical NFkB pathways on both tumors and LECs cocultured with Tregs, inhibits tumor growth and migration in vitro. Leveraging in vivo Treg LTa1b2 interactions with LTβR on tumor and LECs, transfer of WT but not LTa-/- Tregs promotes B16F10 melanoma growth and tumor cell-derived chemokines in LTβR-/- mice; and increases SOX18 and FLRT2 in lymphatic vessels of LTbR-/-melanoma. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL16570
4 Samples

Download data

Series

Accession:: GSE271338

ID:: 200271338

Analyze with GEO2R

Select item 2002465156.

Hepatic Gene Expression

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Expression profiling by array

Platforms:: GPL23479 GPL16570
12 Samples

Download data: CEL, CHP

Series

Accession:: GSE246515

ID:: 200246515

Analyze with GEO2R

Select item 2002465147.

Hepatic Gene Expression Induced by CREB-H-ΔTC

(Submitter supplied) The cAMP-response element binding protein H (CREB-H) is a transcription factor expressed in liver and intestinal tissues. It is well known for regulating many lipid and glucose metabolism genes. Our group aimed to screen for additional or potential genes that may be downstream of CREB-H transcription. To prevent inaccuracy arisen from endogenous CREB-H expression, we used CREB-H-knockout (CREB-H KO) mice for this study.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL16570
6 Samples

Download data: CEL, CHP

Series

Accession:: GSE246514

ID:: 200246514

Analyze with GEO2R

Select item 2001209128.

Oncogenic Kras G12D activation in the non-hematopoietic bone marrow microenvironment causes myelodyplastic syndrom in mice

(Submitter supplied) The bone marrow microenvironment is key player in the regulation and maintenance of hematopoiesis and is also involved in the pathogenesis of hematologic malignancies. We investigated the effect of KrasG12D expression in the non-hematopoietic bone marrow microenvironment. Therefore, we generated chimeric mice which express oncogenic Kras only in the non-hematopoietic system. Within 6-8 weeks, these mice developed a myelodysplastic syndrome characterized by cytopenia, myeloid expansion and signs of disturbed differentiation and marked dysplasia within the myeloid lineage. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL16570
29 Samples

Download data: CEL

Series

Accession:: GSE120912

ID:: 200120912

PubMed Analyze with GEO2R

Select item 2002759669.

Expression data from mouse meningies - home cage (HC) and chronic social defeat (SD) stress mice

(Submitter supplied) CSD stress leads to transcriptional changes in the meninges indicative of increased immune system activation. We have characterized lymphopenia (B cell depletion) and possible fibroblast contribution to neutrophil trafficking at arachnoid barrier cells (ABCs) with this data set.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL16570
14 Samples

Download data: CEL, TXT

Series

Accession:: GSE275966

ID:: 200275966

PubMed

Select item 20023545010.

Aging-associated increase in Golgi stress disturbs cellular signaling and epigenetic regulation

(Submitter supplied) The process of aging is associated with disturbed mineral homeostasis, such as zinc deficiency. Simultaneously, cellular response to external stimuli, including receptor signaling and DNA repair response diminishes, and epigenetic dysregulation occurs. The Golgi apparatus plays various roles in the cell; however, the effect of aging on the morphology and function of the Golgi apparatus and the impact of Golgi senescence in cellular activity remains unknown. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL16570
4 Samples

Download data: CEL

Series

Accession:: GSE235450

ID:: 200235450

Analyze with GEO2R

Select item 20023794211.

Gene expression profile with the p38 inhibitor treatment

(Submitter supplied) Mice bone marrow cells induced dendritic cells were treated with a p38 inhibitor, we used Microgenearry to analyze the dendritic cell-related gene expression, which was induced by a p38 inhibitor. Mice were treated with CAR-T cells with or without p38 inhibitor treatment, we used Microgenearry to analyze the dendritic cell-related gene expression in the tumor environment. Tumor tissues (~100 mg/mouse, 12 days after ACT) were harvested and total RNA was extracted with the RNeasy Mini kit (Qiagen).

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL16570
12 Samples

Download data: CEL

Series

Accession:: GSE237942

ID:: 200237942

Analyze with GEO2R

Select item 20027040512.

Transcriptomic analysis of mammary tumor biospy from MMTV-ErbB2 transgenic mice [Doxorubicin]

(Submitter supplied) The tyrosine kinase ErbB2 positive breast tumors have more aggressive tumor growth, poorer clinical outcome, and more resistance to radiotherapy, chemotherapy and hormone therapy. To identify the biomarkers for predicting the responses to chemotherapy, we treated genetically diverse F1 backcross (F1Bx) mice between C57BL/6J and FVB/N MMTV-Erbb2 transgenic mice with mammary tumor by doxorubicin. Biopsies were taken in sterile conditions and processed for RNA and histological analysis before treatment. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL16570
50 Samples

Download data: CEL

Series

Accession:: GSE270405

ID:: 200270405

Analyze with GEO2R

Select item 20017893913.

Effects of Irbesartan on Gene Expression Profiles in Kidney Tissues of Diabetic db/db Mice

(Submitter supplied) Diabetic nephropathy(DN) is a common diabetic microvascular complication, Irbesartan is the first-line drug for clinical treatment of diabetic nephropathy, but its pharmacological mechanism and target are not yet fully clear. We used microarrays to explore the global profile of gene expression for better understanding the action mechanism of irbesartan in alleviating renal injuries of diabetic db/db mice

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL16570
9 Samples

Download data: CEL

Series

Accession:: GSE178939

ID:: 200178939

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20024104414.

Microarray data, 4 week HFD/NCD, nostim or 16hrstim

(Submitter supplied) How autoimmunity is initiated in Multiple Sclerosis (MS) is unknown, but both genetic and environmental factors have been implicated. Female physiology is associated with a three times higher risk of MS and the ratio of woman to men diagnosed with MS has been increasing over time, suggesting that environmental factors are interacting with female sex to initiate this disease. One MS risk factor that has been increasing that interacts with female sex is obesity. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL16570
18 Samples

Download data: CEL

Series

Accession:: GSE241044

ID:: 200241044

Analyze with GEO2R

Select item 20026741015.

Comparative analysis of WT and XCR1 KO type 1 conventional dendritic cells [array]

(Submitter supplied) XCR1 is known as a signature receptor of type 1 conventional dendritic cells To compare the transcriptomic differences of WT and XCR1 deficient type 1 conventional dendritic cells, we conducted microarry using type 1 conventional dendritic cells from WT and XCR1 KO mice

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL16570
2 Samples

Download data: CEL, XLSX

Series

Accession:: GSE267410

ID:: 200267410

Analyze with GEO2R

Select item 20023821216.

Diurnal gene expression profiles in mouse brain tissues constituting the central dopamine system

(Submitter supplied) The circadian regulation of gene expression underlies orchestrated daily rhythms in physiology, metabolism, and behavior. The central dopamine (DA) system arising from DA neurons in the ventral midbrain has been implicated in a wide range of brain functions. Growing evidence suggests that DA transmission follows daily oscillations at multiple regulatory steps, and its dysfunction is closely related to the onset of various neuropsychiatric diseases. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL16570
48 Samples

Download data: CEL

Series

Accession:: GSE238212

ID:: 200238212

Analyze with GEO2R

Select item 20023477717.

Microarray analysis of regenerating parietal cells (PCs) in murine gastric epithelium recovering from Diphtheria toxin injury

(Submitter supplied) Highly specialized, acid-secreting PCs are one of many epithelial lineages that line the gastric epithelium. Even though PCs are functionally and structurally distinct from other lineages in the stomach, the molecular mechanisms that govern their specification and maturation from the gastric stem cells are relatively unknown. We used microarray analysis to interrogate transcriptional changes that occur in regenerating PCs and to identify candidate regulators of PC fate specification and maturation.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL16570
7 Samples

Download data: CEL, CHP

Series

Accession:: GSE234777

ID:: 200234777

Select item 20023224418.

Differential Expression Data from Mice 24hrs after stroke

(Submitter supplied) Microglial activation after stroke may lead to development of inflammation-induced brain damage. Here we uncover a ribosome-based mechanism/check point involved in control of the innate immune response and microglial activation orchestrated by RNA binding protein SRSF3. Using an in vivo model-system for analysis of the dynamic translational state of microglial ribosomes with mRNAs as input and newly synthesized peptides as an output, we found a marked dissociation of microglia mRNA and protein signatures following ischemic stroke. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL16570
6 Samples

Download data: CEL, CHP, XLSX

Series

Accession:: GSE232244

ID:: 200232244

Select item 20026118419.

Novel role of ALPI gene associated with constipation caused by complement component 3 deficiency

(Submitter supplied) To pinpoint a distinctive gene associated with constipation resulting from C3 deficiency, we conducted microarray hybridization using total RNA extracted from the mid colon of C3 knockout (C3 KO) mice. Identification of causal genes through comparison of gene expression levels in mice induced with C3 deficiency.