GEO DataSets

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Macaca fascicularis; Mus musculus; Murina leucogaster; Peromyscus leucopus; Tamias sibiricus; Papio anubis; Ursus americanus; Petaurus breviceps; Castor canadensis

Type:

Expression profiling by high throughput sequencing

9 related Platforms

90 Samples

Download data

(Submitter supplied) Lifespan varies both within and across species, but the general principles of its control are not understood. To identify transcriptomic signatures of mammalian longevity, we sequenced multiple organs of young adult mammals corresponding to 8 different species, including Canadian beaver, long-tailed macaque, greater tube-nosed bat, baboon, white-footed mouse, sugar glider, Siberian chipmunk and American black bear. more...

Organism:

Petaurus breviceps; Murina leucogaster; Papio anubis; Ursus americanus; Peromyscus leucopus; Tamias sibiricus; Macaca fascicularis; Castor canadensis

Type:

Expression profiling by high throughput sequencing

8 related Platforms

48 Samples

Download data: CSV

(Submitter supplied) We report the whole genome transcriptomic responses of ape species (human, common chimpanzee) and AAMs (rhesus macaque and olive baboon) to bacterial and viral stimulation. We find stark differences in the responsiveness of these groups, with apes mounting a markedly stronger early transcriptional response to both viral and bacterial stimulation, altering the transcription of ∼40% more genes than AAMs. more...

Organism:

Papio anubis; Macaca mulatta; Pan troglodytes; Homo sapiens

Type:

Expression profiling by high throughput sequencing

4 related Platforms

151 Samples

Download data: TXT

(Submitter supplied) Neural stem progenitor cells (NSPCs) in the human subventricular zone (SVZ) potentially contribute to life-long neurogenesis, yet subtypes of glioblastoma multiforme (GBM) contain NSPC signatures that highlight the importance of cell fate regulation. Among numerous regulatory mechanisms, the post-translational methylations onto histone tails are crucial regulator of cell fate. The work presented here focuses on the role of two repressive chromatin marks tri-methylations on histone H3 lysine 27 (H3K27me3) and histone H4 lysine 20 (H4K20me3) in the adult NSPC within the SVZ. more...

Organism:

Papio anubis

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL18808

3 Samples

Download data: BED

(Submitter supplied) Histone 3 Lysine 9 (H3K9) methylation is known to be associated with pericentric heterochromatin and important in genomic stability. In this study, we show that trimethylation at H3K9 (H3K9me3) is enriched in an adult neural stem cell niche- the subventricular zone (SVZ) on the walls of the lateral ventricle in both rodent and non-human primate baboon brain. Previous studies have shown that there is significant correlation between baboon and human regarding genomic similarity and brain structure, suggesting that findings in baboon are relevant to human. more...

Organism:

Papio anubis

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL18808

1 Sample

Download data: XLS

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Papio anubis

Type:

Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL18808

3 Samples

Download data: BED, FPKM_TRACKING

(Submitter supplied) Histone 3 lysine 4 trimethylation (H3K4me3) is known to be associated with transcriptionally active or poised genes and required for postnatal neurogenesis within the subventricular zone (SVZ) in the rodent model. Previous comparisons have shown significant correlation between baboon (Papio anubis) and human brain. In this study, we demonstrate that chromatin activation mark H3K4me3 is present in undifferentiated progenitor cells within the SVZ of adult baboon brain. more...

Organism:

Papio anubis

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL18808

2 Samples

Download data: BED

(Submitter supplied) Histone 3 lysine 4 trimethylation (H3K4me3) is known to be associated with transcriptionally active or poised genes and required for postnatal neurogenesis within the subventricular zone (SVZ) in the rodent model. Previous comparisons have shown significant correlation between baboon (Papio anubis) and human brain. In this study, we demonstrate that chromatin activation mark H3K4me3 is present in undifferentiated progenitor cells within the SVZ of adult baboon brain. more...

Organism:

Papio anubis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL18808

1 Sample

Download data: FPKM_TRACKING