GEO DataSets

(Submitter supplied) Oncostatin M (OSM) is an IL-6 family cytokine that is necessary for neutrophil recruitment in pneumonia by inducing STAT3-dependent production of CXCL5. We used microarrays to identify additional pathways affected by OSM neutralization in the lungs during pneumonia.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL19485

6 Samples

Download data: CEL

(Submitter supplied) Primary murine hepatocytes were transfected with siRNA targeting Caveolin-1 directly after attachment (o/n). Next day, cells were treated with TGF-beta for 48 h. Experiment was performed in triplicate using primary cells from 3 donor mice.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL19485

12 Samples

Download data: CEL

(Submitter supplied) Phosphate is essential for healthy bone growth and plays an essential role in fracture repair. Although phosphate deficiency has been shown to impair fracture healing, the mechanisms involved in impaired healing are unknown. More recently, studies have shown that the effect of phosphate deficiency on the repair process varied based on the genetic strain of mice, which is not characterized. We used data from microarrays to (1) determine the effects of phosphate restriction on the biologic functions identified from the gene expression in fracture calluses; and (2) examine whether there are genetic differences within the primary biologic functions.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19485

239 Samples

Download data: CEL

(Submitter supplied) Multiciliated cells are crucial for fluid and ion transport in epithelia of a variety of organs and their impaired development and function are seen in human diseases affecting the brain, respiratory, and reproductive tracts. Multiciliogenesis requires activation of a specialized transcription program coupled to complex cytoplasmic events that lead to large-scale centriole amplification to generate multicilia. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL19485

18 Samples

Download data: CEL

(Submitter supplied) Cachexia is an exacerbating event in many types of cancer that is strongly associated with a poor prognosis. We have identified cytokine, signaling and transcription factors that are required for cachexia in the mouse C26 colon carcinoma model of cancer. C2C12 myotubes treated with conditioned medium from C26 cancer cells induced atrophy and activated a STAT-dependent reporter gene but not reporter genes dependent on SMAD, FOXO, C/EBP, NF-ĸB, or AP-1. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL19485

12 Samples

Download data: CEL, TXT

(Submitter supplied) Differentiation of muscle tissue is regulated by a complex network of transcription factors. The MEF2 family of transcription factors are important players in muscle development and differentiation. We knocked down expression of MEF2 isoforms in a cell culture model of skeletal muscle differentiation and assessed global expression pattern changes between MEF2 knockdowns, and with a negative control.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL19485

15 Samples

Download data: CEL