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Intrinsic histone-DNA interactions and low nucleosome density are important for accessibility of promoters in yeast

(Submitter supplied) In yeast cells, preferential accessibility of the HIS3-PET56 promoter region is determined by a general property of the DNA sequence, not by defined sequence elements. In vivo, this region is largely devoid of nucleosomes, and accessibility is directly related to reduced histone density. The HIS3-PET56 and DED1 promoter regions associate poorly with histones in vitro, indicating that intrinsic nucleosome positioning and stability is a major determinant of preferential accessibility. more...
Organism:
Saccharomyces cerevisiae
Type:
Genome binding/occupancy profiling by array; Genome binding/occupancy profiling by genome tiling array
Platforms:
GPL2045 GPL2046
6 Samples
Download data: GPR
Series
Accession:
GSE2659
ID:
200002659

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