GPL21650[RGSE] - GEO DataSets

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Items: 3

Select item 2001290341.

Comparison of chromatin accessibility between human and non-human primates

(Submitter supplied) Evolution of transcriptional regulation is thought to be a major cause of the evolution of phenotypic traits. We compared DNase I Hypersensitive sites in fibroblast cells from five primates (human, chimpanzee, gorilla, orangutan, and macaque). We identified approximately 90,000 DHS sites, of which 59% are not significantly different between species, 27% are differential and likely due to a single evolutionary change, and 14% are differential and likely due to multiple changes. more...

Organism:: Macaca mulatta; Homo sapiens; Gorilla gorilla; Pongo pygmaeus; Pan troglodytes

Type:: Genome binding/occupancy profiling by high throughput sequencing

7 related Platforms
15 Samples

Download data: BED

Series

Accession:: GSE129034

ID:: 200129034

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001007962.

Human-specific features of special gene expression and regulation in eight brain regions

(Submitter supplied) Despite the substantial efforts made to compile the molecular maps of the human brain, they do not fully inform us of the features unique to humans. Yet, identification of these features might help us to understand both the evolution and nature of the human cognitive traits. Here, we approached this question by analyzing gene expression and H3K27ac chromatin modification data collected in eight brain regions of humans, chimpanzees, gorillas, gibbon and macaques. more...

Organism:: Hylobates lar; Gorilla gorilla; Pan troglodytes; Homo sapiens

Type:: Expression profiling by high throughput sequencing

7 related Platforms
107 Samples

Download data: TXT

Series

Accession:: GSE100796

ID:: 200100796

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000795663.

Whole genome DNA methylation profile of sperm cells in mammalian species

(Submitter supplied) DNA methylation in sperm is among the most important factors shaping evolution of the mammalian genome. By directly altering germline mutation rates, the DNA methylation system has shaped the CpG landscape of mammalian genomes, resulting in the CpG island phenomenon. Yet little is known about how this system itself has co-evolved with its substrate during mammalian evolution. We analyzed full-genome single-CpG DNA methylation profiles in sperm from human, chimp, gorilla, rhesus, mouse, rat and dog. more...