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Items: 1 to 20 of 137

1.

Comparison of transcriptomic profile of the murine B16F1-GFP-M melanoma cells with the derived dormant B16F1-GFP-D, B16F1-GFP-DB#1, B16F1-GFP-DB#2, B16F1-GFP-DB#3 melanoma cells

(Submitter supplied) Cancer patients after successful therapy contain nested in their organs and/or circulating in the systemic fluids tumor cells that remain asymptomatic for an extended period of time. They stay dormant with no apparent immediate potential to develop into a clinically manifested tumor until activated by yet not well defined mechanisms. We previously developed tumor dormancy model of murine melanoma, a cancer with a high potential of phenotype plasticity to adapt to micro-environmental changes, in which to investigate cellular quiescence and related factors as a potential mechanism of tumour dormancy. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL21810
24 Samples
Download data: TXT
Series
Accession:
GSE250145
ID:
200250145

PubMed Full text in PMC Similar studies Analyze with GEO2R

2.

Long-term Urolithin A treatment ameliorates disease pathology in Alzheimer's Disease mouse models

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus; Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL32699 GPL21810 GPL32670
82 Samples
Download data: RCC, TXT
Series
Accession:
GSE214417
ID:
200214417

PubMed Full text in PMC Similar studies Analyze with GEO2R

3.

Long-term Urolithin A treatment ameliorates disease pathology in Alzheimer's Disease mouse models [I]

(Submitter supplied) Alzheimer's disease (AD) is a progressive neurodegenerative disorder associated with learning, memory, and cognitive deficits. Neuroinflammation and lysosomal dysfunction are thought to play key roles in the progression of AD pathology. Diverse measures have been applied to treat AD, but currently, there is no effective treatment. Urolithin A (UA) is a gut microbial metabolite of ellagic acid shown to stimulate mitophagy and acts as a potent anti-inflammatory and anti-oxidant agent. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL21810
24 Samples
Download data: TXT
Series
Accession:
GSE212972
ID:
200212972

PubMed Full text in PMC Similar studies Analyze with GEO2R

4.

In vitro stimulation of mouse spleen cells by mouse urine

(Submitter supplied) Urinary tract-associated lymphoid structures (UTLASs), tertiary lymphoid tissues, are formed in renal pelvis (RP) of humans and mice with chronic kidney disease. We found that UTALS development was accelerated by urine leakage from RP lumen to the parenchyma following dysfunction of transitional epithelium covering UTLASs. Thus, UTALS-forming cells were stimulated by urine including urinary bio active substances.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL21810
3 Samples
Download data: TXT, XLSX
Series
Accession:
GSE207999
ID:
200207999

PubMed Similar studies Analyze with GEO2R

5.

Fibroblast growth factor (FGF) 10 is essential for lung morphogenesis

(Submitter supplied) Fibroblast growth factor (FGF) 10 is essential for lung morphogenesis and polymorphisms in the Fgf10 region are linked with higher susceptibility towards COPD in human patients. We found that FGF10 signaling is impaired in lung septal wall compartment from COPD patients. Mice with impaired FGF10 signaling (Fgf10+/-) were more prone to develop cigarette smoke (CS)-induced emphysema and pulmonary hypertension (PH). more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL21810
68 Samples
Download data: GPR
Series
Accession:
GSE230854
ID:
200230854

Analyze with GEO2R

6.

Effect of SOCS2 R96C mutation on mouse mammary gland development and function

(Submitter supplied) The R96C mutation in SOCS2 (suppressor of cytokine signaling 2) that leads to greater milk production but also a greater sensitivity to mastitis was identified in Lacaune sheep by Rupp et al, 2015. This mutation leads to a loss of ligand recognition for SOCS2 and thus interferes with JAK/STAT signaling pathway regulation. A mouse model carrying this mutation (SOCS2 R96C KI) was developed to study its effects on mammary gland development and lactation.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL21810
24 Samples
Download data: TXT
Series
Accession:
GSE225441
ID:
200225441

PubMed Similar studies Analyze with GEO2R

7.

Gene expression analysis of the skeletal muscles of a mouse model of spinal and bulbar muscular atrophy (SBMA) with or without exercise

(Submitter supplied) To investigate the molecular pathway underlying the effect of exercise, we performed microarray gene expression analysis of the quadriceps of transgenic mice carrying full-length human androgen receptor (AR) with 97 CAGs (AR97Q) at 9 weeks of age with or without exercise. Exercise was started from 5 weeks of age and maintained for 4 weeks.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL21810
6 Samples
Download data: TXT
Series
Accession:
GSE209885
ID:
200209885

PubMed Full text in PMC Similar studies Analyze with GEO2R

8.

BRAFV600E expression in intestinal tissue promotes a cholesterol metabolic gene signature that sustains hyperplasia and characterizes serrated colorectal neoplasia

(Submitter supplied) BRAF mutations occur early in serrated colorectal cancers, but their long-term influence on tissue homeostasis are poorly characterized. We investigated the impact of short-term (3 days) and long-term (6 months) expression of BrafV600E in the intestinal tissue of an inducible mouse model. We show that BrafV600E perturbs the homeostasis of intestinal epithelial cells, with impaired differentiation of enterocytes emerging after prolonged expression of the oncogene. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL21810
20 Samples
Download data: TXT
Series
Accession:
GSE234372
ID:
200234372

PubMed Full text in PMC Similar studies Analyze with GEO2R

9.

Sequential early life infections alter peripheral blood transcriptomics in aging female mice but not the response to de novo infection with influenza virus or M. tuberculosis

(Submitter supplied) The experimental mouse model is important for understanding the impact of aging on immune function. Humans are exposed to multiple pathogens during their lifetime, which has a significant effect on immune function as they age, while laboratory mice are aged under specific pathogen-free (SPF) conditions, reducing their exposure to pathogens throughout life. To determine the impact of accumulating antigen exposure on immunity in the aging mouse, and to develop a more relevant model, we sequentially infected young female mice with four distinct pathogens, a murine g-herpesvirus (gHV68), Sendai virus, murine cytomegalovirus (mCMV) and Heligmosomoides polygyrus (H. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL21810
48 Samples
Download data: TXT
Series
Accession:
GSE199730
ID:
200199730

PubMed Full text in PMC Similar studies Analyze with GEO2R

10.

Acetaminophen

(Submitter supplied) 8 and 80 week old mice treated with acetaminophen
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL21810
8 Samples
Download data: TXT
Series
Accession:
GSE149740
ID:
200149740

Analyze with GEO2R

11.

Investigation of the anti-tumour properties of interferon epsilon in high grade serous ovarian cancer

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by array; Expression profiling by high throughput sequencing
Platforms:
GPL21810 GPL30172 GPL21697
96 Samples
Download data: TXT
Series
Accession:
GSE201525
ID:
200201525

PubMed Similar studies Analyze with GEO2R

12.

Investigation of the direct activity of interferon epsilon on ID8 ovarian cancer cells in vitro.

(Submitter supplied) This experiment is part of a larger study examining the anti-tumour properties of interferon epsilon in ovarian cancer. The objective of this experiment was to examine the direct activity of interferon epsilon on the mouse ovarian cancer cell line, ID8, and compare it to equivalent unit concentrations of interferon beta. The goal was to determine whether interferon epsilon and interferon beta induce different patterns of gene expression in ID8 cells.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL21810
24 Samples
Download data: TXT
Series
Accession:
GSE201345
ID:
200201345

PubMed Similar studies Analyze with GEO2R

13.

Transcriptomic profiling of draining lymph nodes from immunized neonatal mice.

(Submitter supplied) Differential gene expression in mouse lymph nodes at 2 different time points following administration of antigen alone or together with adjuvant.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL21810
43 Samples
Download data: TXT
Series
Accession:
GSE226513
ID:
200226513

PubMed Full text in PMC Similar studies Analyze with GEO2R

14.

Modified method for differentiation of myeloid-derived suppressor cells in vitro enhances immunosuppressive ability via glutathione metabolism

(Submitter supplied) Myeloid-derived suppressor cells (MDSCs), which accumulate in tumor bearers, are known to suppress anti-tumor immunity and thus promote tumor progression. MDSCs are considered a major cause of resistance against immune checkpoint inhibitors in patients with cancer. Therefore, MDSCs are potential targets in cancer immunotherapy. In this study, we modified an in vitro method of MDSC differentiation. Upon stimulating bone marrow (BM) cells with granulocyte-macrophage colony-stimulating factor in vitro, we obtained both lymphocyte antigen 6G positive (Ly-6G+) and negative (Ly-6G−) MDSCs (collectively, hereafter referred to as conventional MDSCs), which were non-immunosuppressive and immunosuppressive, respectively. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL21810
6 Samples
Download data: TXT
Series
Accession:
GSE218704
ID:
200218704

PubMed Full text in PMC Similar studies Analyze with GEO2R

15.

Gene expression profile of B cells from OPN-competent and deficient Faslpr autoimmune mice

(Submitter supplied) We performed gene expression profile on splenic CD19+ cells from autoimmune Faslpr/lpr and OPN-/-Faslpr/lpr mice to investigate the dynamics at the basis of the more incident transformation characterizing OPN-deficient animals. GEP on splenic CD19+ from BALB/c and OPN-/- mice was performed as control.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL21810
14 Samples
Download data: TXT
Series
Accession:
GSE193790
ID:
200193790

PubMed Full text in PMC Similar studies Analyze with GEO2R

16.

Whole brain transcriptome of wild-type or Nav1.8CreROSA26DTA mice upon LPS sepsis

(Submitter supplied) To check changes in transcriptome in whole brain upon LPS sepsis, mice were injected with PBS or LPS and gene expression was analyzed. Nav1.8CreROSA26DTA mice lack Nav1.8-positive nociceptor.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL21810
4 Samples
Download data: TXT
Series
Accession:
GSE173216
ID:
200173216

PubMed Similar studies Analyze with GEO2R

17.

Fourteen commensals restore immunocompetence in adult germfree mice via maturation of the intestinal vascular system

(Submitter supplied) The intestinal microbiota influences the development of a normal intestinal physiology, education and functioning of the mucosal immune system. The goal of this study is to analyze how the transcriptional profile of the colonic endothelial cells is influence by colonization of gnotobiotic mice with specific bacterial strains . The goal of this study is to analyze how the transcriptional profile of the colonic endothelial cells is influence by colonization of gnotobiotic mice with specific bacterial strains .
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL21810
4 Samples
Download data: TXT
Series
Accession:
GSE180907
ID:
200180907

PubMed Full text in PMC Similar studies Analyze with GEO2R

18.

Glucocorticoid imprints a low glucose metabolism onto CD8 T cells and induces the persistent suppression of the immune response

(Submitter supplied) To elucidate the effect of predonisolone on CD8 T cell differentiation, we have measured gene expression in predonisolone-treated CD8 cells.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL21810
2 Samples
Download data: TXT
Series
Accession:
GSE168090
ID:
200168090

PubMed Similar studies Analyze with GEO2R

19.

C-section delivery related high sensitivity to inflammation in mice is unchained by gut barrier-microbiota imbalances in the early life

(Submitter supplied) The main goal of this study is to decipher the role of CSD in the early-life gut microbiota-barrier alterations and its links with later-life risks of intestinal inflammation
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL21810
16 Samples
Download data: TXT
Series
Accession:
GSE214311
ID:
200214311

PubMed Full text in PMC Similar studies Analyze with GEO2R

20.

Monoamine oxidase-dependent pro-survival signaling in diabetic hearts

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Non-coding RNA profiling by array; Expression profiling by array
Platforms:
GPL21810 GPL21265
24 Samples
Download data: TXT
Series
Accession:
GSE210612
ID:
200210612

PubMed Full text in PMC Similar studies Analyze with GEO2R

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