GEO DataSets

(Submitter supplied) The analysis of RNA-sequencing data reveals the proportion of the three viruses simultaneously inoculated into humanized mice.

Organism:

Human immunodeficiency virus 1

Type:

Other

Platform:

GPL23868

17 Samples

Download data: TXT

(Submitter supplied) We report deep mutational scanning data for the Env protein's LLP-2 domain in the NL4-3 strain HIV-1 Env. Processed Data repersents counts for each amino acid pre and post spread

Organism:

Human immunodeficiency virus 1

Type:

Other

Platform:

GPL23868

76 Samples

Download data: TAB

(Submitter supplied) The goal of this study was to determine how an HIV quasispecies is maintained in the face of selection. We deep sequenced the HIV provirus from cell populations as well as single cells at different time points from in vitro evolution experiments and found that when a less fit and more fit infect the same cell, they share components (complmentation) and therefore allow the less fit to perpetuate. We reproduced a quasispecies to an HIV reverse transcriptase inhibitor. more...

Organism:

Human immunodeficiency virus 1

Type:

Genome variation profiling by high throughput sequencing

Platform:

GPL23868

207 Samples

Download data: CSV

(Submitter supplied) The goal of this set of experiments is to determine the structure of HIV-1 NL4-3 and NHG RNA structure using a novel algorithm that allows for the identification of multiple RNA folding conformations. The input data used for this algorithm is DMS-MaPseq data. We focused on two specific areas of the HIV-1 genome, the Rev Response Element (RRE) and A3 splice acceptor site, as well as probing the whole HIV-1 genome. more...

Organism:

Vibrio vulnificus; synthetic construct; Homo sapiens; Human immunodeficiency virus 1

Type:

Other

7 related Platforms

23 Samples

Download data: TXT

(Submitter supplied) The HIV-1 surface glycoprotein Env binds target receptors to mediate fusion of the viral and host cell membranes during infection. Env is incorporated with very low density into virions, and in some cell types, regions within the long cytosolic C-terminal tail may mediate direct or indirect associations with Gag during virus assembly and budding. Here, the mutational landscape is determined across the transmembrane and proximal cytosolic domains of Env (001428 isolate from clade C) interacting with the MA domain of Gag at cellular membranes. more...

Organism:

Human immunodeficiency virus 1

Type:

Other

Platform:

GPL23868

5 Samples

Download data: XLSX

(Submitter supplied) HIV-1 infection begins with binding of the viral envelope glycoprotein Env to the host receptor CD4, triggering a series of conformational changes that lead to fusion of the virus and cell membranes. Env, a trimer of gp120 and gp41 subunits, occupies a ‘closed’ conformation with contacts between gp120 subunits at the apex, and transitions through an ‘open’ conformation with the gp120 subunits spread apart following CD4 binding. more...

Organism:

Human immunodeficiency virus 1

Type:

Other

Platforms:

GPL22068 GPL23868

21 Samples

Download data: XLSX