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Items: 1 to 20 of 37

1.

Elevated enhancer-oncogene contacts and higher oncogene expression levels by recurrent CTCF inactivating mutations in acute T cell leukemia

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing; Genome variation profiling by genome tiling array; Methylation profiling by array; Other
5 related Platforms
171 Samples
Download data: HIC, IDAT, NARROWPEAK, RDS, TXT
Series
Accession:
GSE182317
ID:
200182317
2.

Elevated enhancer-oncogene contacts and higher oncogene expression levels by recurrent CTCF inactivating mutations in acute T cell leukemia [Array CGH]

(Submitter supplied) CCCTC-binding factor (CTCF) regulates the 3D chromatin architecture by facilitating chromosomal loops. In addition to insulation of euchromatin from heterochromatin, CTCF is an important transcription factor and regulator of antigen receptor and T cell receptor recombination events. CTCF inactivating events have been found in human cancer, resulting in deregulation of global gene expression by altered methylated genomic states. more...
Organism:
Homo sapiens
Type:
Genome variation profiling by genome tiling array
Platforms:
GPL2879 GPL9777 GPL4093
93 Samples
Download data: TXT
Series
Accession:
GSE182312
ID:
200182312
3.

SMAD4 haploinsufficiency in small intestinal neuroendocrine tumors

(Submitter supplied) Background: Patients with small intestinal neuroendocrine tumors (SINETs) frequently present with lymph node and liver metastases at the time of diagnosis, but the molecular changes that lead to the progression of these tumors are largely unknown. Sequencing studies have only identified recurrent point mutations in a single gene, CDKN1B, with heterozygous mutations in less than 10% of all tumors. Although SINETs are genetically stable tumors with a low frequency of point mutations and indels, they often harbor recurrent hemizygous copy number alterations (CNAs) yet the functional implications of these CNA are unclear. more...
Organism:
Homo sapiens
Type:
Genome variation profiling by genome tiling array
6 related Platforms
131 Samples
Download data: TXT
Series
Accession:
GSE153314
ID:
200153314
4.

19p loss is significantly enriched in older age neuroblastoma patients and correlates with poor prognosis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Genome variation profiling by array
4 related Platforms
208 Samples
Download data: TXT
Series
Accession:
GSE145341
ID:
200145341
5.

19p loss is significantly enriched in older age neuroblastoma patients and correlates with poor prognosis (Agilent-013282, dataset 2)

(Submitter supplied) Genomic aberrations of neuroblastoma occurring in late childhood and adolescence are uncommon and still underestimated. Public DNA copy number profiles of 556 tumors (discovery set) and of 208 tumors obtained by array-CGH assay (validation set) were used to verify if 19p loss is significantly over-represented in children and adolescents. The 19p loss occurrence was separately tested within different age groups in the discovery and validation set and the resulting P values were combined and corrected by Bonferroni’s method. more...
Organism:
Homo sapiens
Type:
Genome variation profiling by array
Platform:
GPL2879
17 Samples
Download data: TXT
Series
Accession:
GSE145337
ID:
200145337
6.

19p loss is significantly enriched in older age neuroblastoma patients and correlates with poor prognosis (Agilent-013282, dataset 1)

(Submitter supplied) Genomic aberrations of neuroblastoma occurring in late childhood and adolescence are uncommon and still underestimated. Public DNA copy number profiles of 556 tumors (discovery set) and of 208 tumors obtained by array-CGH assay (validation set) were used to verify if 19p loss is significantly over-represented in children and adolescents. The 19p loss occurrence was separately tested within different age groups in the discovery and validation set and the resulting P values were combined and corrected by Bonferroni’s method. more...
Organism:
Homo sapiens
Type:
Genome variation profiling by array
Platform:
GPL2879
2 Samples
Download data: TXT
Series
Accession:
GSE145336
ID:
200145336
7.

Chromosome 17/17q gain and unaltered profiles in high resolution array-CGH are prognostically informative in neuroblastoma

(Submitter supplied) Oligonucleotide aCGH profiles from 37 neuroblastoma tumor samples were generated using 44K or 105K microarrays.
Organism:
Homo sapiens
Type:
Genome variation profiling by genome tiling array
Platforms:
GPL4093 GPL2873 GPL2879
37 Samples
Download data: TXT
Series
Accession:
GSE56109
ID:
200056109
8.

Low- and High-Grade Mucoepidermoid Carcinomas have different genomic profiles and CRTC1-MAML2 Fusion Gene Status

(Submitter supplied) Using high-resolution oligonucleotide arrayCGH, FISH, and RT-PCR we have performed a comprehensive analysis of genomic imbalances, and CRTC1-MAML2 gene fusion status in a series of 28 well characterized mucoepidermoid carcinomas (MECs) with the aims to identify distinct differences in genomic profiles and CRTC1-MAML2 gene fusion status between low- and high-grade MECs.
Organism:
Homo sapiens
Type:
Genome variation profiling by array
Platforms:
GPL2879 GPL4091
28 Samples
Download data: TXT
Series
Accession:
GSE36282
ID:
200036282
9.

Clonal competition with alternating dominance in multiple myeloma

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Genome variation profiling by array; Expression profiling by array
Platforms:
GPL570 GPL4091 GPL2879
104 Samples
Download data: CEL, TXT
Series
Accession:
GSE36825
ID:
200036825
10.

Clonal competition with alternating dominance in multiple myeloma [44kCGH]

(Submitter supplied) Copy number and Gene expression profiling multiple myeloma patients at multiple stages of their individual clinical course Identification of evolutionary paterns in multiple myeloma
Organism:
Homo sapiens
Type:
Genome variation profiling by array
Platform:
GPL2879
7 Samples
Download data: TXT
Series
Accession:
GSE36823
ID:
200036823
11.

High-resolution, genome-wide analysis of human metastatic neuroblastoma samples by array-Comparative Genomic Hybridization (aCGH)

(Submitter supplied) Neuroblastoma (NB) is an aggressive tumor that affects both infants and children. The disease outcome is greatly influenced by age of patient, stage, chromosome copy number aberrations (CNAs) and gene expression abnormalities. We analyzed, by microarray technology, genome and transcriptome of 3 groups of tumors of patients with metastatic disease: G1, stage 4S and MYCN single copy; G2, stage 4 younger than 18 months of age, MYCN single copy with no disease progression and G3, stage 4, older than 19 months, with unfavorable outcome. more...
Organism:
Homo sapiens
Type:
Genome variation profiling by array
4 related Platforms
133 Samples
Download data: TXT
Series
Accession:
GSE25771
ID:
200025771
12.

Array-Comparative Genomic Hybridization Reveals Loss of SOCS6 is Associated with Poor Prognosis in Primary Lung Squamous Cell Carcinoma

(Submitter supplied) Primary tumor recurrence occurs commonly after surgical resection of lung squamous cell carcinoma (SCC). The aim of this study was to identify genes involved in recurrence in lung squamous cell carcinoma patients. Array comparative genomic hybridization (aCGH) was performed on DNA extracted from tumour tissue from 62 patients with primary lung squamous cell carcinomas. aCGH data was analysed to identify genes affected by copy number alterations that may be involved in SCC recurrence. more...
Organism:
Homo sapiens
Type:
Genome variation profiling by genome tiling array
Platform:
GPL2879
62 Samples
Download data: TXT
Series
Accession:
GSE32058
ID:
200032058
13.

Integrative genomic, transcriptomic and RNAi analysis indicates a potential oncogenic role for FAM110B in castration-resistant prostate cancer.

(Submitter supplied) Background: Castration-resistant prostate cancer (CRPC) represents a therapeutic challenge for current medications. Methods: In order to explore the molecular mechanisms involved in CRPC progression and to identify new therapeutic targets, we analyzed a unique sample set of 11 castration-resistant prostate cancers and 7 advanced tumors by array-CGH and gene expression microarrays. The genome-wide DNA and RNA data were integrated to identify genes whose overexpression was driven by their amplification. more...
Organism:
Homo sapiens
Type:
Expression profiling by array; Genome variation profiling by genome tiling array
4 related Platforms
47 Samples
Download data: CEL, TXT
Series
Accession:
GSE28403
ID:
200028403
14.

Gene copy number variation in male breast cancer by aCGH

(Submitter supplied) Characterization of DNA imbalances in a set of 25 MBC samples analyzed by high resolution CGH arrays in order to detect DNA copy number aberrations (CNAs). These results have been then compared with a female breast cancer dataset deposited with the Gene Expression Omnibus.
Organism:
Homo sapiens
Type:
Genome variation profiling by array
Platforms:
GPL2879 GPL5477
25 Samples
Download data: TXT
Series
Accession:
GSE23891
ID:
200023891
15.

Genetic Copy Number Variants in Sib Pairs Both Affected with Schizophrenia

(Submitter supplied) Genome-wide screening for DNA copy-number variations (CNVs) was conducted for ten pairs, a total of 20 cases, of affected siblings using oligonucleotide array-based CGH. We found negative symptoms were significantly more severe (p < 0.05) in the subgroup that harboring more genetic imbalance (n ≧ 13, n = number of CNV-disrupted genes) as compared with the subgroup with fewer CNVs (n ≦ 6), indicating the degree of genetic imbalance may influence the severity of schizophrenia negative symptoms. more...
Organism:
Homo sapiens
Type:
Genome variation profiling by array
Platform:
GPL2879
20 Samples
Download data: TXT
Series
Accession:
GSE16930
ID:
200016930
16.

DNA copy number data from the CTCR-OV01 study

(Submitter supplied) All patients with suspected ovarian cancer (Raised CA 125 and a complex pelvic mass in a perimenopausal woman) were radiologically staged using CT scan and a chest x-ray. Patients with evidence of intra-abdominal metastasis and/or malignant pleural effusion were approached for entry to the study. Tissue biopsy was obtained either under radiological control (core needle biopsy) or via laparoscopic surgery (punch biopsy). more...
Organism:
Homo sapiens
Type:
Genome variation profiling by array
Platform:
GPL2879
105 Samples
Download data: TXT
Series
Accession:
GSE18453
ID:
200018453
17.

Deletion of the WWOX gene and frequent loss of its protein expression 3 in human osteosarcoma

(Submitter supplied) Array comparative genomic hybridization on 10 frozen osteosarcoma specimens
Organism:
Homo sapiens
Type:
Genome variation profiling by array
Platform:
GPL2879
10 Samples
Download data: TXT
Series
Accession:
GSE19180
ID:
200019180
18.

Genetic characterization of tumor-stage mycosis fungoides

(Submitter supplied) Mycosis fungoides patients who develop tumors or extracutaneous involvement usually have a poor prognosis with no curative therapy available so far. In the present EORTC multicenter study, the genomic profile of 41 skin biopsies from tumor-stage mycosis fungoides was analyzed using a high-resolution oligo-array comparative genomic hybridization platform. Seventy-six percent of cases showed genomic aberrations. more...
Organism:
Homo sapiens
Type:
Genome variation profiling by genome tiling array
Platforms:
GPL2879 GPL5477
41 Samples
Download data: TXT
Series
Accession:
GSE18098
ID:
200018098
19.

DNA packaging of human and murine spermatozoal chromatin

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; Mus musculus
Type:
Genome variation profiling by array; Genome binding/occupancy profiling by genome tiling array; Genome variation profiling by genome tiling array
6 related Platforms
16 Samples
Download data: GFF, PAIR, TXT
Series
Accession:
GSE13238
ID:
200013238
20.

DNA packaging of human spermatozoal chromatin

(Submitter supplied) During mammalian spermiogenesis, the majority of the nucleosomes packaging the male haploid genome are replaced by protamines to produce a highly compact chromatin architecture that is critical to male fertility. We have carried out a genomewide survey of human spermatozoal chromatin using both a salt and micrococal nuclease approach to characterise the DNA sequences that remain packaged by histones.
Organism:
Homo sapiens
Type:
Genome variation profiling by array; Genome variation profiling by genome tiling array
Platforms:
GPL16300 GPL2879 GPL4091
12 Samples
Download data: TXT
Series
Accession:
GSE12088
ID:
200012088
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