GPL30071[RGSE] - GEO DataSets

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Items: 3

Select item 2002130051.

A network of small RNAs regulates sporulation initiation in C. difficile

(Submitter supplied) The obligate anaerobic, enteric pathogen Clostridioides difficile persists in the intestinal tract by forming antibiotic resistant endospores that contribute to relapsing and recurrent infections. Despite the importance of sporulation for C. difficile pathogenesis, environmental cues, and molecular mechanisms regulating sporulation initiation remain ill defined. Here, using RIL-seq to capture the Hfq-dependent RNA-RNA interactome, we discovered a network of small RNAs that bind to mRNAs encoding sporulation-related genes. more...

Organism:: Clostridioides difficile

Type:: Other

Platform:: GPL30071
8 Samples

Download data: TXT

Series

Accession:: GSE213005

ID:: 200213005

PubMed Full text in PMC Similar studies

Select item 2001991092.

The licorice metabolite enoxolone attenuates Clostridioides difficile pathophysiology by corrupting its metabolic and toxin production networks

(Submitter supplied) Toxins TcdA and TcdB are the main virulence factors of Clostridioides difficile, a leading cause of hospital-acquired diarrhea. We investigated the therapeutic potential of inhibiting the biosynthesis of TcdA and TcdB. Accordingly, screening of structurally diverse phytochemicals with medicinal properties identified 18b-glycyrrhetinic acid (enoxolone) as an inhibitor of TcdA and TcdB biosynthesis. Enoxolone also inhibited sporulation. more...

Organism:: Clostridioides difficile

Type:: Expression profiling by high throughput sequencing

Platform:: GPL30071
6 Samples

Download data: TXT

Series

Accession:: GSE199109

ID:: 200199109

Select item 2001738043.

Clostridioides difficile strain dependent and independent adaptations to a microaerobic environment

(Submitter supplied) Clostridioides difficile (formerly Clostridium difficile) colonizes the gastrointestinal tract following disruption of the microbiota and can initiate a spectrum of clinical manifestations ranging from asymptomatic to life-threatening colitis. Following antibiotic treatment, luminal oxygen concentrations increase, exposing gut microbes to potentially toxic reactive oxygen species (ROS). Though typically regarded as a strict anaerobe, C. more...