Comparative transcriptomics reveals circadian and pluripotency networks as two pillars of longevity regulation - - GEO DataSets

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Comparative transcriptomics reveals circadian and pluripotency networks as two pillars of longevity regulation

(Submitter supplied) Mammals differ more than 100-fold in maximum lifespan. Here, we conducted comparative transcriptomics on 26 species with diverse lifespans. We identified thousands of genes with expression levels negatively or positively correlated with a species' maximum lifespan (Neg- or Pos-MLS genes). Neg-MLS genes are primarily involved in energy metabolism and inflammation. Pos-MLS genes show enrichment in DNA repair, microtubule organization, and RNA transport. more...

Organism:: Mesocricetus auratus; Mus musculus; Sciurus carolinensis; Tamias striatus; Neotoma cinerea; Condylura cristata; Fukomys damarensis; Bramus lutescens; Peromyscus maniculatus; Ondatra zibethicus; Hydrochoerus hydrochaeris; Cuniculus paca; Cricetulus barabensis; Blarina brevicauda; Tamiasciurus hudsonicus; Rattus rattus; Myocastor coypus; Heterocephalus glaber; Castor canadensis; Acomys russatus; Marmota monax; Cavia porcellus; Octodon degus; Chinchilla lanigera; Scalopus aquaticus

Type:: Expression profiling by high throughput sequencing

25 related Platforms
522 Samples

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Accession:: GSE190756

ID:: 200190756

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