GEO DataSets

(Submitter supplied) We evaluated the efficacy of combining pembrolizumab (anti-PD1 antibody), exemestane (nonsteroidal aromatase inhibitor), and leuprolide (gonadotropin-releasing hormone agonist) for 15 patients with ER+/HER2− premenopausal MBC who had failed one to two lines of hormone therapy without chemotherapy.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL32069

11 Samples

Download data: RCC

(Submitter supplied) We aimed to investigate the immune profile of AA-related RCC and explore its potential role as a predictive biomarker for ICB. Three distinct clusters were found through functional pathway analysis using the NanoString gene expression panel. AA-positive ccRCC comprised the majority of cluster 1 and 3, and the two patients with good response to ICB were grouped to Cluster 3. Cluster 3 exhibited higher tumor inflammation signature (TIS) and immune cell type scores.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL32069

24 Samples

Download data: RCC

(Submitter supplied) Metastases in the brain are the most severe and devastating complication of cancer. The incidence of brain metastasis is increasing. Therefore, the need of finding specific druggable targets for brain metastasis is demanding. The aim of this study was to compare the brain (immune) response to brain metastases of the most common tumor lineages, viz., lung adenocarcinoma and breast cancer. Targeted gene expression profiles of 11 brain metastasis of lung adenocarcinoma (BM-LUAD) were compared to 11 brain metastasis of breast cancer (BCBM) using NanoString nCounter PanCancer IO 360™ Panel. more...

Organism:

Homo sapiens

Type:

Other

Platform:

GPL32069

22 Samples

Download data: CSV

(Submitter supplied) Plexiform neurofibromas (PNF) are benign peripheral nerve sheath tumors (PNST) that arise in persons with neurofibromatosis type 1 (NF1). Despite similar histological appearance, these neoplasms proceed along diverse evolutionary trajectories, with a subset progressing to a devastating form of sarcoma called malignant peripheral nerve sheath tumor (MPNST), the leading cause of premature death in individuals with NF1. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL32069

35 Samples

Download data: RCC, TXT

(Submitter supplied) Introduction: The incidence of brain metastases in cancer patients is increasing, with lung and breast cancer being the most common sources. Despite advancements in targeted therapies, the prognosis remains poor, highlighting the importance to investigate the underlying mechanisms in brain metastases. The aim of this study was to investigate the differences in the molecular mechanisms involved in brain metastasis of breast and lung cancers. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL32069

44 Samples

Download data: CSV

(Submitter supplied) Existing immune markers and tumor mutational burden signatures have modest predictive accuracies of immune-check-point inhibitors (ICI) therapeutic efficacy. In this study, we developed an immune metabolic signature suitable for personalized ICI therapies. A classifier using an immune-metabolic signature (IMMETCOLS) was developed on a training set of 75 metastatic colorectal cancer (mCRC) samples and validated on 4,200 tumors from the TCGA database belonging to 11 types. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL32069

77 Samples

Download data: RCC

(Submitter supplied) Tobacco use is an independent adverse prognostic feature in human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC). Despite this, the biologic features associated with tobacco use have not been systematically investigated in this population. We sought to characterize the genomic and immunologic features of HPV(+) OPSCC associated with tobacco use and adverse oncologic outcomes. more...

Organism:

Homo sapiens

Type:

Other

Platform:

GPL32069

44 Samples

Download data: TXT