GEO DataSets

(Submitter supplied) Notch signaling promotes T-cell pathogenicity and graft-versus-host disease (GVHD) after allogeneic hematopoietic cell transplantation (allo-HCT) in mice, with a dominant role for the Delta-like ligand DLL4. To assess if Notch’s effects are evolutionarily conserved and identify key mechanisms, we studied antibody-mediated DLL4 blockade in a non-human primate (NHP) model similar to human allo-HCT. Short-term DLL4 blockade improved post-transplant survival with striking, durable protection from gastrointestinal GVHD, out of proportion to other disease sites. more...

Organism:

Macaca mulatta

Type:

Expression profiling by array

Platform:

GPL3535

107 Samples

Download data: CEL

(Submitter supplied) CD4+ T follicular helper (TFH) cells are key targets for human immunodeficiency virus (HIV)/simian immunodeficiency virus (SIV) replication and contribute to the virus reservoir under antiretroviral therapy (ART). Here, we describe a novel CD3+ CD20+ double-positive (DP) lymphocyte subset, resident in secondary lymphoid organs of humans and rhesus macaques (RMs), that appear predominantly after membrane exchange between TFH and B cells. more...

Organism:

Macaca mulatta

Type:

Expression profiling by array

Platform:

GPL3535

50 Samples

Download data: CEL

(Submitter supplied) We studied time course of pathological remodeling occurring in the hearts of cynomolgus monkey, Macaca fascicularis against atrioventricular block condition. We used microarrays to detail the pathological changes in the hearts which had obtained sensitivity for detecting dl-sotalol-induced TdP by 7th month after the production of atrioventricular block.

Organism:

Macaca fascicularis; Macaca mulatta

Type:

Expression profiling by array

Platform:

GPL3535

6 Samples

Download data: CEL, XLS

(Submitter supplied) Alcohol preferring vervet dams were permitted to ingest alcohol 4 days/week during the second half of gestation (e90-e165) and paired with sucrose matched controls. Cases and controls were sacrificed with subsequent hippocampal extraction at 5 months and 2 years. RNA was extracted according to the manufacturer's protocol and hybridized to the Affymetrix Rhesus Genechip microarray. We sought to identify pathways and genes involved in the development of fetal alcohol spectrum disorder in a non-human primate in order to develop an understanding of how this disorder may develop in humans.

Organism:

Chlorocebus aethiops; Macaca mulatta

Type:

Expression profiling by array

Platform:

GPL3535

24 Samples

Download data: CEL

(Submitter supplied) The effect of a long-term calorie restricted diet was evaluated in PBMCs of rhesus monkeys For biopsy collection, the animals were given buprenorphine (0.01-0.03 mg/kg, IM) in the morning immediately preceding all biopsies and again that afternoon

Organism:

Macaca mulatta

Type:

Expression profiling by array

Platform:

GPL3535

14 Samples

Download data: CEL, CHP

(Submitter supplied) Treatment for many viral infections of the central nervous system (CNS) remains only supportive. Here we address a remaining gap in our knowledge regarding how the CNS and immune systems interact during viral infection. By examining the regulation of the immune and nervous system processes in a nonhuman primate model of West Nile virus neurological disease, we show that virus infection disrupts the homeostasis of the immune-neural-synaptic axis via induction of pleiotropic genes with distinct functions in each component of the axis. more...

Organism:

Macaca mulatta

Type:

Expression profiling by array

Platform:

GPL3535

26 Samples

Download data: CEL, CHP

(Submitter supplied) Identify LXR-responsive genes in rhesus macaque luteal cells isolated from CL at 12 days post LH-surge

Organism:

Macaca mulatta

Type:

Expression profiling by array

Platform:

GPL3535

6 Samples

Download data: CEL, CHP

(Submitter supplied) Progestin-based contraception may increase the risk of vaginal HIV acquisition to a level greater than the progesterone-rich luteal phase of the menstrual cycle, which has been demonstrated to have a significantly higher transmission rate compared to the follicular phase. We used pig-tailed macaque (Macaca nemestrina) model to evaluate the effects of administration of the oral the combined oral contraceptives (COCs) depot medroxyprogesterone acetate (DMPA) and levonorgestrel (LNG) on mucosal factors that influence HIV susceptibility. more...

Organism:

Macaca nemestrina; Macaca mulatta

Type:

Expression profiling by array

Platform:

GPL3535

58 Samples

Download data: CEL

(Submitter supplied) We used microarrays to detail the global gene expression changes in the ileum of SIV-infected and uninfected macaques following administration of L. plantarum.

Organism:

Macaca mulatta

Type:

Expression profiling by array

Platform:

GPL3535

12 Samples

Download data: CEL

(Submitter supplied) The effect of a long-term calorie restricted diet was evaluated in vastus lateralis muscle of rhesus monkeys For biopsy collection, the animals were given buprenorphine (0.01-0.03 mg/kg, IM) in the morning immediately preceding all biopsies and again that afternoon

Organism:

Macaca mulatta

Type:

Expression profiling by array

Platform:

GPL3535

13 Samples

Download data: CEL, CHP

(Submitter supplied) Despite recent extensive genomic and genetic studies on behavioral responses to ethanol, relatively few new therapeutic targets for the treatment of alcohol use disorder have been validated. Here we describe a cross-species genomic approach focused on identifying gene networks associated with chronic ethanol consumption. To identify brain mechanisms underlying a chronic ethanol consumption phenotype highly relevant to human alcohol use disorder, and to elucidate potential future therapeutic targets, we conducted a genomic study in a nonhuman primate model of chronic open-access ethanol consumption. more...

Organism:

Macaca mulatta

Type:

Expression profiling by array

Platform:

GPL3535

43 Samples

Download data: CEL

(Submitter supplied) An efficacious vaccine to HIV-1 remains elusive. We tested two vaccine regimens based on prime-boosting with two chimpanzee-origin adenovirus (Ad) vectors (SAdV) of serotypes SAdV24 and SAdV23 or two distinct human serotype Ad vectors (HAdV), i.e., HAdV5 and HAdV26, expressing Gag and gp160 of SIVmac239 for induction of protection against repeated low dose rectal SIVmac251 challenges in Indian rhesus macaques (RMs). more...

Organism:

Macaca mulatta

Type:

Expression profiling by array

Platform:

GPL3535

82 Samples

Download data: CEL

(Submitter supplied) Macaca fascicularis (long-tailed, cynomolgus, or crab-eating macaque) is a highly advantageous model in which to study human cochlea with regard to both evolutionary proximity and physiological similarity of the auditory system. To better understand the properties of primate cochlear function, we analyzed the genes predominantly expressed in M. fascicularis cochlea.

Organism:

Macaca fascicularis; Macaca mulatta; Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL3535 GPL570

4 Samples

Download data: CEL

(Submitter supplied) It has been hypothesized that lentiviral infection might exacerbate age-related neurodegenerative processes. This study used microarrays to detail gene expression in the midfrontal cortex from aged macaques chronically infected with SIVmac251 with and without antiretroviral therapy along with non-infected counterparts.

Organism:

Macaca mulatta

Type:

Expression profiling by array

Platform:

GPL3535

30 Samples

Download data: CEL

(Submitter supplied) Graft versus host disease (GVHD) is the most common complication of hematopoietic stem cell transplant (HCT). However, our understanding of the molecular pathways that cause this disease remains incomplete, leading to inadequate treatment strategies. To address this, we measured the gene expression profile of non-human primate (NHP) T cells during acute GVHD. In this study we specifically interrogated the transcriptional signatures of animals treated with FR104 monotherapy and FR104/Sirolimus combination therapy

Organism:

Macaca mulatta

Type:

Expression profiling by array

Platform:

GPL3535

108 Samples

Download data: CEL, TXT

(Submitter supplied) Classically, the cytidine deaminase APOBEC3G (A3G) exerts antiviral activity against transposable elements, retroviruses, and hepatitis B virus. However, we found earlier, that it also inhibits measles (MV), mumps (MuV) and respiratory syncytial virus (RSV), but the mechanism of inhibition remained unclear. Because A3G is present in RNA processing (P) bodies, where it is involved in the regulation of mRNA decay, we supposed that it may influence the expression of host cell factors, some of which may affect viral replication. more...

Organism:

Macaca mulatta; Chlorocebus sabaeus

Type:

Expression profiling by array

Platform:

GPL3535

4 Samples

Download data: CEL

(Submitter supplied) In contrast to SIVagm, which does not cause disease in its natural simian host, HIV-1 expresses the accessory protein Vpu and encodes a Nef protein that fails to suppress T cell activation via down-modulation of CD3. Although both, Vpu and Nef have been implicated as pathogenicity determinants, their relevance for viral replication and disease progression in vivo has remained unclear. Here, we analyzed gene expression in African green monkeys infected with SIVagm chimeras differing in their expression of nef and/or vpu. more...

Organism:

Macaca mulatta; Chlorocebus sabaeus

Type:

Expression profiling by array

Platform:

GPL3535

12 Samples

Download data: CEL

(Submitter supplied) Graft versus host disease (GVHD) is the most common complication of hematopoietic stem cell transplant (HCT). However, our understanding of the molecular pathways that cause this disease remains incomplete, leading to inadequate treatment strategies. To address this, we measured the gene expression profile of non-human primate (NHP) T cells during acute GVHD. In this study we specifically interrogated the transcriptional signatures of animals treated with KY1005 monotherapy and KY1005/Sirolimus combination therapy

Organism:

Macaca mulatta

Type:

Expression profiling by array

Platform:

GPL3535

102 Samples

Download data: CEL

(Submitter supplied) The progression to AIDS is influenced by changes in the biology of heterogeneous monocyte subsets. Classical (CD14++CD16-), intermediate (CD14++CD16+), and nonclassical (CD14+CD16++) monocytes may represent progressive stages of monocyte maturation or disparate myeloid lineages with different turnover rates and function. To investigate the relationship between monocyte subsets and the response to SIV infection, we performed microarray analysis of monocyte subsets in rhesus macaques at three timepoints: prior to SIV infection, 26 days post-infection, and necropsy with AIDS. more...

Organism:

Macaca mulatta

Type:

Expression profiling by array

Platform:

GPL3535

30 Samples

Download data: CEL

(Submitter supplied) CD8+ T-cells inhibit virus replication in SIV-infected rhesus macaques (RM). However, it is not clear how SIV infection is controlled in germinal center during chronic SIV infection and limited information exists on the characteristics of CXCR5+ CD8 T cells during chronic SIV/HIV infection. In this study, we used functional genomics to investigate characteristic features and potential mechanisms of CXCR5+ and CXCR5- SIV specific CD8 T cells for the control of pathogenic SIV infection. more...

Organism:

Macaca mulatta

Type:

Expression profiling by array

Platform:

GPL3535

12 Samples

Download data: CEL