GSE180556[Accession] - GEO DataSets

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Items: 3

Select item 2001805561.

Expression data of murine T-ALL OT-1 (Tot-1si) with early expression of mature alphabeta TCR

(Submitter supplied) In mice and humans, an immature CD4-CD8- double negative (DN) thymocyte subset expresses early, mature αβTCR. These early αβTCR+ DN (EADN) cells are susceptible to leukemogenesis in both species. Using the OT-1 TCR transgenic system to model EADN-stage αβ TCR expression, we found that EADN cells show coreceptor-independent reactivity to MHC, and their TCR:MHC dependent signals can drive T-ALL transformation. more...

Organism:: Mus musculus

Type:: Expression profiling by array; Third-party reanalysis

Platform:: GPL6246
1 Sample

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Series

Accession:: GSE180556

ID:: 200180556

PubMed Full text in PMC Similar studies

Select item 1000062462.

[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version]

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 July 01, 2016: annotation table updated with netaffx build 35 Protocol: See manufacturer's web site