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Items: 7

1.

TRIM37 augments AP-2γ transcriptional activity and cellular localization via K63-linked polyubiquitination to drive breast cancer progression [ChIP-seq]

(Submitter supplied) Using a proteomics approach, we identified the Tripartite Motif Containing 37 (TRIM37) as a novel transcriptional coactivator of AP-2γ. We demonstrate TRIM37 facilitates AP-2γ chromatin binding to regulate the AP-2γ mediated transcriptional program directly. We provide evidence that TRIM37 achieves this by stimulating K63-chain-linked polyubiquitination of AP-2γ, promoting protein localization from the cytoplasm to the nucleus. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL11154
5 Samples
Download data: BED, BW
Series
Accession:
GSE182546
ID:
200182546
2.

Illumina HiSeq 2000 (Homo sapiens)

Platform
Accession:
GPL11154
ID:
100011154
3.

MCF-7 Mouse IgG ChIP-Seq

Organism:
Homo sapiens
Source name:
breast cancer cell line
Platform:
GPL11154
Series:
GSE182546 GSE182547
Download data
Sample
Accession:
GSM5531139
ID:
305531139
4.

MCF-7 AP2C siTRIM37 ChIP-Seq

Organism:
Homo sapiens
Source name:
breast cancer cell line
Platform:
GPL11154
Series:
GSE182546 GSE182547
Download data: BED, BW
Sample
Accession:
GSM5531138
ID:
305531138
5.

MCF-7 AP2C Negative Control ChIP-Seq

Organism:
Homo sapiens
Source name:
breast cancer cell line
Platform:
GPL11154
Series:
GSE182546 GSE182547
Download data: BED, BW
Sample
Accession:
GSM5531137
ID:
305531137
6.

MCF-7 Rabbit IgG ChIP-Seq

Organism:
Homo sapiens
Source name:
breast cancer cell line
Platform:
GPL11154
Series:
GSE182546 GSE182547
Download data
Sample
Accession:
GSM5531136
ID:
305531136
7.

MCF-7 TRIM37 ChIP-Seq

Organism:
Homo sapiens
Source name:
breast cancer cell line
Platform:
GPL11154
Series:
GSE182546 GSE182547
Download data: BED, BW
Sample
Accession:
GSM5531135
ID:
305531135
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Supplemental Content

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