(Submitter supplied) Thalidomide has a dark history as a teratogen, but in recent years its derivates have been shown to function as a chemotherapeutic agent. These drugs bind cereblon (CRBN), the substrate receptor of an E3 ubiquitin ligase complex and modify its degradation targets. Despite these insights, remarkably little is known about the normal function of cereblon in development. Here we employ Ciona, an invertebrate chordate, to identify endogenous Crbn targets.
more...- Organism:
- Ciona intestinalis
- Type:
- Expression profiling by high throughput sequencing
- Platform:
- GPL29701
- 2 Samples
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