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Items: 1 to 20 of 24

1.

Examination of inflammatory transcripts during a transfer model of type I diabetes.

(Submitter supplied) In an accompanying paper we found specific localization of diabetogenic T cells only to islets of Langerhans bearing the specific antigen. Instrumental in the specific localization was the presence of intra-islet dendritic cells bearing the β-cell-peptide-MHC complex. Here we report that the entry of diabetogenic CD4 T cells very rapidly triggered inflammatory gene expression changes in islets and vessels by up-regulating chemokines and adhesion molecules. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Datasets:
GDS4115 GDS4116
Platform:
GPL6246
20 Samples
Download data: CEL, CHP
Series
Accession:
GSE26147
ID:
200026147

PubMed Full text in PMC Similar studies Analyze with GEO2R

2.
Full record GDS4116

Diabetogenic BDC T-cell transfer model of type I diabetes: pancreatic islets

Analysis of pancreatic islets after injection of diabetogenic BDC CD4 T cells into nondiabetic NOD Rag1-/- recipients, 24 to 48 hrs post-transfer. Results provide insight into molecular mechanisms underlying the T-cell entry induced state of receptivity of islets to subsequent immunological insults.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 cell type, 2 genotype/variation, 3 protocol, 3 time sets
Platform:
GPL6246
Series:
GSE26147
13 Samples
Download data: CEL, CHP
DataSet
Accession:
GDS4116
ID:
4116

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

3.
Full record GDS4115

Diabetogenic 3A9 T-cell transfer model of type I diabetes: pancreatic islets

Analysis of islet cells after injection of diabetogenic 3A9 CD4 T cells into nondiabetic B10.BR IP-HEL recipients, 8 to 24 hrs post-transfer. Results provide insight into molecular mechanisms underlying the T-cell entry induced state of receptivity of islets to subsequent immunological insults.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation, 2 protocol, 3 time sets
Platform:
GPL6246
Series:
GSE26147
7 Samples
Download data: CEL, CHP
DataSet
Accession:
GDS4115
ID:
4115

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

4.

[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version]

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 July 01, 2016: annotation table updated with netaffx build 35 Protocol: See manufacturer's web site
Organism:
Mus musculus
143 DataSets
2496 Series
28 Related Platforms
30138 Samples
Download data
Platform
Accession:
GPL6246
ID:
100006246

5.

BDC into NOD.RAG-/- (48 hrs.) 3

Organism:
Mus musculus
Source name:
pancreatic islets of Langerhans, BDC T cell transfer into NOD.RAG-/- strain, 48 hrs.
Platform:
GPL6246
Series:
GSE26147
Dataset:
GDS4116
Download data: CEL, CHP
Sample
Accession:
GSM641892
ID:
300641892

6.

BDC into NOD.RAG-/- (48 hrs.) 2

Organism:
Mus musculus
Source name:
pancreatic islets of Langerhans, BDC T cell transfer into NOD.RAG-/- strain, 48 hrs.
Platform:
GPL6246
Series:
GSE26147
Dataset:
GDS4116
Download data: CEL, CHP
Sample
Accession:
GSM641891
ID:
300641891

7.

BDC into NOD.RAG-/- (48 hrs.) 1

Organism:
Mus musculus
Source name:
pancreatic islets of Langerhans, BDC T cell transfer into NOD.RAG-/- strain, 48 hrs.
Platform:
GPL6246
Series:
GSE26147
Dataset:
GDS4116
Download data: CEL, CHP
Sample
Accession:
GSM641890
ID:
300641890

8.

BDC into NOD.RAG-/- (24 hrs.) purified beta cells

Organism:
Mus musculus
Source name:
purified beta cells, BDC T cell transfer into NOD.RAG-/- strain, 24 hrs.
Platform:
GPL6246
Series:
GSE26147
Dataset:
GDS4116
Download data: CEL, CHP
Sample
Accession:
GSM641889
ID:
300641889

9.

BDC into NOD.IFNGR-/- (48 hrs.) 2

Organism:
Mus musculus
Source name:
pancreatic islets of Langerhans, BDC T cell transfer into NOD.IFNGR-/- strain, 48 hrs.
Platform:
GPL6246
Series:
GSE26147
Dataset:
GDS4116
Download data: CEL, CHP
Sample
Accession:
GSM641888
ID:
300641888

10.

BDC into NOD.IFNGR-/- (48 hrs.) 1

Organism:
Mus musculus
Source name:
pancreatic islets of Langerhans, BDC T cell transfer into NOD.IFNGR-/- strain, 48 hrs.
Platform:
GPL6246
Series:
GSE26147
Dataset:
GDS4116
Download data: CEL, CHP
Sample
Accession:
GSM641887
ID:
300641887

11.

BDC into NOD.RAG-/- (24 hrs.)

Organism:
Mus musculus
Source name:
pancreatic islets of Langerhans, BDC T cell transfer into NOD.RAG-/- strain, 24 hrs.
Platform:
GPL6246
Series:
GSE26147
Dataset:
GDS4116
Download data: CEL, CHP
Sample
Accession:
GSM641886
ID:
300641886

12.

BDC into NOD.IFNGR-/- (24 hrs.)

Organism:
Mus musculus
Source name:
pancreatic islets of Langerhans, BDC T cell transfer into NOD.IFNGR-/- strain, 24 hrs.
Platform:
GPL6246
Series:
GSE26147
Dataset:
GDS4116
Download data: CEL, CHP
Sample
Accession:
GSM641885
ID:
300641885

13.

B6.g7 splenocytes into NOD.RAG (24 hrs.)

Organism:
Mus musculus
Source name:
pancreatic islets of Langerhans, B6.g7 splenocytes transfer into NOD.RAG-/- strain, 24 hrs.
Platform:
GPL6246
Series:
GSE26147
Dataset:
GDS4116
Download data: CEL, CHP
Sample
Accession:
GSM641884
ID:
300641884

14.

untreated purified beta cells

Organism:
Mus musculus
Source name:
purified beta cells, NOD.RAG-/- strain, untreated
Platform:
GPL6246
Series:
GSE26147
Dataset:
GDS4116
Download data: CEL, CHP
Sample
Accession:
GSM641883
ID:
300641883

15.

untreated NOD.RAG 3

Organism:
Mus musculus
Source name:
pancreatic islets of Langerhans, NOD.RAG-/- strain, untreated
Platform:
GPL6246
Series:
GSE26147
Dataset:
GDS4116
Download data: CEL, CHP
Sample
Accession:
GSM641882
ID:
300641882

16.

untreated NOD.RAG 2

Organism:
Mus musculus
Source name:
pancreatic islets of Langerhans, NOD.RAG-/- strain, untreated
Platform:
GPL6246
Series:
GSE26147
Dataset:
GDS4116
Download data: CEL, CHP
Sample
Accession:
GSM641881
ID:
300641881

17.

untreated NOD.RAG 1

Organism:
Mus musculus
Source name:
pancreatic islets of Langerhans, NOD.RAG-/- strain, untreated
Platform:
GPL6246
Series:
GSE26147
Dataset:
GDS4116
Download data: CEL, CHP
Sample
Accession:
GSM641880
ID:
300641880

18.

3A9 into IP-HEL (24 hrs.) 3

Organism:
Mus musculus
Source name:
pancreatic islets of Langerhans, 3A9 T cell transfer into insulin promoter HEL transgenic strain, 24 hrs.
Platform:
GPL6246
Series:
GSE26147
Dataset:
GDS4115
Download data: CEL, CHP
Sample
Accession:
GSM641879
ID:
300641879

19.

3A9 into IP-HEL (24 hrs.) 2

Organism:
Mus musculus
Source name:
pancreatic islets of Langerhans, 3A9 T cell transfer into insulin promoter HEL transgenic strain, 24 hrs.
Platform:
GPL6246
Series:
GSE26147
Dataset:
GDS4115
Download data: CEL, CHP
Sample
Accession:
GSM641878
ID:
300641878

20.

3A9 into IP-HEL (24 hrs.) 1

Organism:
Mus musculus
Source name:
pancreatic islets of Langerhans, 3A9 T cell transfer into insulin promoter HEL transgenic strain, 24 hrs.
Platform:
GPL6246
Series:
GSE26147
Dataset:
GDS4115
Download data: CEL, CHP
Sample
Accession:
GSM641877
ID:
300641877

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