GEO DataSets

(Submitter supplied) The homeobox genes of the orthodenticle (otd)/Otx family play conserved roles in embryogenesis of the head and brain. Gene replacement experiments show that the Drosophila otd gene and orthologous mammalian Otx genes are functionally equivalent, in that overexpression of either gene in null mutants of Drosophila or mouse can restore defects in cephalic and brain development. This suggests that otd and Otx genes can control a comparable subset of downstream target genes in either organism. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Dataset:

GDS23

Platform:

GPL70

16 Samples

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Analysis of the effects of overexpression of orthodenticle homeobox genes otd (Drosophila) and Otx2 (human) reveals evolutionary conservation. The otd/Otx2 homeobox genes play a role in embryogenesis of the head and brain.

Organism:

Drosophila melanogaster

Type:

Expression profiling by array, count, 2 shock, 3 strain sets

Platform:

GPL70

Series:

GSE32

16 Samples

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(Submitter supplied) Custom-designed Drosophila oligonucleotide array (Affymetrix, Santa Clara, CA). It contains 14,090 sequences representing 13,369 single transcripts encoding Drosophila proteins deposited in SWISS-PROT/TrEMBL databases (Celera Genome/BDGP Release no. 1) as well as prokaryotic and custom chosen control sequences. Each sequence is represented on the array by a set of 14 oligonucleotide probes of matching sequence and 14 probes with a single nucleotide mismatch. more...

Organism:

Drosophila melanogaster

1 DataSet

3 Series

44 Samples

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