GSE36083[Accession] - GEO DataSets

Select item 2000360831.

Transcriptomic Analysis of Placenta Affected by Antiphospholipid Antibodies: Following the TRAIL of trophoblast death

(Submitter supplied) Antiphospholipid antibodies, a maternal risk factor for preeclampsia, increase shedding of necrotic trophoblast debris from the placenta, leading to endothelial dysfunction. Using Affymetrix HGU133 Plus 2 microarrays, we found changes in the transcriptome of placental explants treated with antiphospholipid antibodies including seven mRNAs encoding for genes BCL2L1, MCL1, PDCD2L, FASLG, SEMA6A, PRKCE and TRAIL that are involved in the regulation of apoptosis. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4592
Platform:: GPL570
6 Samples

Download data: CEL, TXT

Series

Accession:: GSE36083

ID:: 200036083

Select item 45922.

Antiphospholipid antibody effect on first-trimester placental explants

Analysis of first-trimester placenta explants treated with antiphospholipid antibodies. Antiphospholipid antibodies are a maternal risk factor for preeclampsia. Results provide insight into molecular mechanisms underlying antiphospholipid antibody involvement in preeclampsia pathogenesis.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 3 development stage, 2 protocol sets

Platform:: GPL570
Series:: GSE36083
6 Samples

Download data: CEL

DataSet

Accession:: GDS4592

ID:: 4592

Select item 1000005703.

[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 06, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site Complete coverage of the Human Genome U133 Set plus 6,500 additional genes for analysis of over 47,000 transcripts All probe sets represented on the GeneChip Human Genome U133 Set are identically replicated on the GeneChip Human Genome U133 Plus 2.0 Array. more...