GEO DataSets

(Submitter supplied) Uncovering the molecular mechanism of stem cell self-renewal is critical to broaden current therapeutic applications and to understand how its de-regulation may lead to pathological conditions. In this work, we report changes in gene expression and related cell processes during conditions of high in vitro expansion of CD133+/CD34+ primitive stem cells from human umbilical cord blood (UCB). Based on DNA microarray assays, we demonstrate that primary metabolism and cell cycle genes are specifically up-regulated, as well as members of the Wnt and Notch signaling pathways. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL2895 GPL2891

3 Samples

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(Submitter supplied) CodeLink Human Whole Genome Bioarray targets most of the known and predictive genes of the human genome as it is described today in the public domain. It is comprised of approximately 55 000 30-mer probes designed to conserved exons across the transcripts of targeted genes. These 55 000 probes represent well annotated, full length, and partial human gene sequences from major public databases. CodeLink Human Whole Genome Bioarray probe sequences were selected from the NCBI UniGene build #165, RefSeq database (January 5, 2004 release) and dbEST database (January 8, 2004 release). more...

Organism:

Homo sapiens

7 DataSets

69 Series

3 Related Platforms

1589 Samples

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(Submitter supplied) CodeLink UniSet Human Bioarray content was based on the public UniGene and RefSeq databases, and sequences for design were derived from Incyte LifeSeq™ Gold and Foundation databases. Well-annotated mRNA or coding sequences were chosen to ensure usefulness for a large range of applications in basic research, biotechnology, and drug development. Each sequence was carefully screened to ensure high quality, specific probe design, and to reduce redundancy of gene targets. more...

Organism:

Homo sapiens

12 Series

272 Samples

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