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Items: 14

1.

Regulation of ER Homeostasis and Cell Cycle by Pax4 Enhances β-Cell Survival and Protects Mice Against Experimental Autoimmune Diabetes

(Submitter supplied) Strategies to enhance islet b-cell survival and regeneration while refraining inflammation through manipulation of molecular targets would provide means to stably replenish the deteriorating functional b-cell mass detected in both Type 1 and Type 2 Diabetes Mellitus (T1DM and T2DM). Herein we report that over expression of the islet enriched transcription factor Pax4 refrains development of hyperglycemia in the RIP-B7.1 mouse model of T1DM through reduced insulitis, decreased b-cell apoptosis correlating with diminished DNA damage and increased proliferation. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
12 Samples
Download data: CEL
Series
Accession:
GSE62846
ID:
200062846

PubMed Full text in PMC Similar studies Analyze with GEO2R

2.

[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version]

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 July 01, 2016: annotation table updated with netaffx build 35 Protocol: See manufacturer's web site
Organism:
Mus musculus
143 DataSets
2504 Series
28 Related Platforms
30419 Samples
Download data
Platform
Accession:
GPL6246
ID:
100006246

3.

Islet_Pax4R121W/rtTA_-DOX_ Rep3

Organism:
Mus musculus
Source name:
Primary isolated islets from Pax4R121W/rtTA mice untreated
Platform:
GPL6246
Series:
GSE62846
Download data: CEL
Sample
Accession:
GSM1534440
ID:
301534440

4.

Islet_Pax4R121W/rtTA_-DOX_ Rep2

Organism:
Mus musculus
Source name:
Primary isolated islets from Pax4R121W/rtTA mice untreated
Platform:
GPL6246
Series:
GSE62846
Download data: CEL
Sample
Accession:
GSM1534439
ID:
301534439

5.

Islet_Pax4R121W/rtTA_-DOX_ Rep1

Organism:
Mus musculus
Source name:
Primary isolated islets from Pax4R121W/rtTA mice untreated
Platform:
GPL6246
Series:
GSE62846
Download data: CEL
Sample
Accession:
GSM1534438
ID:
301534438

6.

Islet_Pax4R121W/rtTA_+DOX_ Rep3

Organism:
Mus musculus
Source name:
Primary isolated islets from Pax4R121W/rtTA mice treated with DOX
Platform:
GPL6246
Series:
GSE62846
Download data: CEL
Sample
Accession:
GSM1534437
ID:
301534437

7.

Islet_Pax4R121W/rtTA_+DOX_ Rep2

Organism:
Mus musculus
Source name:
Primary isolated islets from Pax4R121W/rtTA mice treated with DOX
Platform:
GPL6246
Series:
GSE62846
Download data: CEL
Sample
Accession:
GSM1534436
ID:
301534436

8.

Islet_Pax4R121W/rtTA_+DOX_ Rep1

Organism:
Mus musculus
Source name:
Primary isolated islets from Pax4R121W/rtTA mice treated with DOX
Platform:
GPL6246
Series:
GSE62846
Download data: CEL
Sample
Accession:
GSM1534435
ID:
301534435

9.

Islet_Pax4/rtTA_-DOX_ Rep3

Organism:
Mus musculus
Source name:
Primary isolated islets from Pax4/rtTA mice untreated
Platform:
GPL6246
Series:
GSE62846
Download data: CEL
Sample
Accession:
GSM1534434
ID:
301534434

10.

Islet_Pax4/rtTA_-DOX_ Rep2

Organism:
Mus musculus
Source name:
Primary isolated islets from Pax4/rtTA mice untreated
Platform:
GPL6246
Series:
GSE62846
Download data: CEL
Sample
Accession:
GSM1534433
ID:
301534433

11.

Islet_Pax4/rtTA_-DOX_ Rep1

Organism:
Mus musculus
Source name:
Primary isolated islets from Pax4/rtTA mice untreated
Platform:
GPL6246
Series:
GSE62846
Download data: CEL
Sample
Accession:
GSM1534432
ID:
301534432

12.

Islet_Pax4/rtTA_+DOX_ Rep3

Organism:
Mus musculus
Source name:
Primary isolated islets from Pax4/rtTA mice treated with DOX
Platform:
GPL6246
Series:
GSE62846
Download data: CEL
Sample
Accession:
GSM1534431
ID:
301534431

13.

Islet_Pax4/rtTA_+DOX_ Rep2

Organism:
Mus musculus
Source name:
Primary isolated islets from Pax4/rtTA mice treated with DOX
Platform:
GPL6246
Series:
GSE62846
Download data: CEL
Sample
Accession:
GSM1534430
ID:
301534430

14.

Islet_Pax4/rtTA_+DOX_ Rep1

Organism:
Mus musculus
Source name:
Primary isolated islets from Pax4/rtTA mice treated with DOX
Platform:
GPL6246
Series:
GSE62846
Download data: CEL
Sample
Accession:
GSM1534429
ID:
301534429

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