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Items: 4

1.

Expression data from adult Rattus liver

(Submitter supplied) Activation of the pregnane X receptor (NR1I2) by drugs and other xenobiotics stimulates (or suppresses) expression of numerous genes involved in the metabolic elimination of foreign compounds and some toxic endogenous substrates. We used microarray analysis to identify genes whose expression in rat liver was significantly altered by pregnenolone 16alpha-carbonitrile (PCN) treatment. Keywords: a single ip injection of PCN (100 mg/kg), 8 h treatment
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Datasets:
GDS2093 GDS2094
Platforms:
GPL341 GPL342
19 Samples
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Series
Accession:
GSE4959
ID:
200004959
2.
Full record GDS2093

Pregnane X receptor agonist effect on the liver (RAE230A)

Analysis of livers of animals treated with pregnenolone 16alpha-carbonitrile (PCN), a pregnane X receptor (NR1I2) agonist. NR1I2 is a member of the nuclear receptor family of ligand-activated transcription factors, and regulates the transcription of genes encoding xenobiotic metabolizing enzymes.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 2 agent sets
Platform:
GPL341
Series:
GSE4959
10 Samples
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3.

[RAE230A] Affymetrix Rat Expression 230A Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 21, 2012: annotation table updated with netaffx build 32 July 01, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site Array A of GeneChip Rat Expression Set 230 Has 15923 entries and was indexed 09-Apr-2003 Sequences used in the design of the array were selected from GenBank, dbEST, and RefSeq. more...
Organism:
Rattus norvegicus
68 DataSets
148 Series
2 Related Platforms
3292 Samples
Download data
Platform
Accession:
GPL341
ID:
100000341
4.

PCN, biological rep5a

Organism:
Rattus norvegicus
Source name:
Rattus, adult liver
Platform:
GPL341
Series:
GSE4959
Dataset:
GDS2093
Download data
Sample
Accession:
GSM111905
ID:
300111905
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