GSM1359550[Accession] - GEO DataSets

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Items: 4

Select item 2000563451.

Therapeutic potential of spleen tyrosine kinase inhibition for treatment of high-risk precursor B-cell acute lymphoblastic leukemia

(Submitter supplied) This study revealed pathogenic role of pre-BCR-independent SYK activation in high-risk B-ALL. Intensified and central nervous system (CNS)-directed chemotherapy has significantly improved outcomes for pediatric B-acute lymphoblastic leukemia (B-ALL), but confers significant late-effect morbidities. Moreover, many patients suffer relapses, underscoring the need to develop novel, molecularly targeted B-ALL therapies. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS5640
Platform:: GPL1261
9 Samples

Download data: CEL, CHP

Series

Accession:: GSE56345

ID:: 200056345

Select item 56402.

Double-knockout p53/PRKDC model of B cell acute lymphoblastic leukemia: leukemic blasts

Analysis of leukemic blasts from p53/Prkdc double-knockout mutants that spontaneously develop early B cell acute lymphoblastic leukemia (B-ALL). Results provide insight into molecular mechanisms underlying high-risk B-ALL.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 3 cell type, 2 genotype/variation sets

Platform:: GPL1261
Series:: GSE56345
9 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS5640

ID:: 5640

Select item 1000012613.

[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site All probe sets represented on the GeneChip Mouse Expression Set 430 are included on the GeneChip Mouse Genome 430 2.0 Array. more...