GEO DataSets

(Submitter supplied) We report the evolutionary behaviour of Polycomb group proteins, their recruitment factors and their underlying sequences by performing ChIP-seq analysis in 4-5 different Drosophila species. We demonstrate an extremely high conservation of Polycomb repressive domains across Drosophila species We validate few cases of PRE divergence that shows that cis-driven PRE evolution is a rare event. We further show that PHO recruitment to Polycomb domains is evolutionarily robust to motif changes and that PRC1 stabilizes binding of its key recruiter

Organism:

Drosophila melanogaster; Drosophila pseudoobscura; Drosophila simulans; Drosophila yakuba; Drosophila virilis

Type:

Genome binding/occupancy profiling by high throughput sequencing

6 related Platforms

70 Samples

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