GSM1564581[Accession] - GEO DataSets

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Items: 4

Select item 2000641141.

Patterns of somatic uniparental disomy identify novel tumor suppressor genes in colorectal cancer

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: SNP genotyping by SNP array; Genome variation profiling by SNP array; Methylation profiling by array

Platforms:: GPL9183 GPL4091 GPL3720
148 Samples

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Accession:: GSE64114

ID:: 200064114

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000641122.

Patterns of somatic uniparental disomy identify novel tumor suppressor genes in colorectal cancer

(Submitter supplied) The aim of this study is to establish an integrative profiling of recurrent UPDs/UPPs, CNAs and genome-wide methylation status in sporadic CRC. Our results indicate that regions showing high frequencies of UPDs/UPPs mostly coincide with regions typically involved in genomic losses such as chromosome arms 1p, 5q, 8p, 14q, 17p, 18q, 20p, and 22q. Of these, chromosome arms 5q, 14q, 17p, and 20p preferentially showed UPDs/UPPs over genomic losses suggesting that tumor cells must maintain the disomic state of certain genes to favor cellular fitness. more...