GSM1607351[Accession] - GEO DataSets

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Items: 3

Select item 2000658341.

Transcriptional profiling of HBV-naïve subjects before vaccination against Hepatitis A/B viruses, Diphtheria/Tetanus toxoids and Cholera.

(Submitter supplied) Mechanisms of poor responses to vaccines remain unknown. Hepatitis B virus-naïve elderly subjects received three vaccines, including a vaccine against hepatitis B virus (HBV). Pre-vaccination high dimensional analyses of blood using transcriptional profiling and flow cytometry revealed that subjects having increased memory B cell frequencies and higher expression of genes downstream of B cell receptor signaling responded more strongly to the HBV vaccine whereas subjects having higher expression of inflammatory related genes and greater numbers of activated innate immune cells showed a weaker response to this vaccine. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL15048
169 Samples

Download data: CEL

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Accession:: GSE65834

ID:: 200065834

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 1000150482.

Rosetta/Merck Human RSTA Custom Affymetrix 2.0 microarray [HuRSTA_2a520709.CDF]

(Submitter supplied) This is an alternate definition for the custom Rosetta/Merck Affymetrix array. For the canonical platform, see GPL10379. Protocol: See manufacturer website.