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Items: 4

1.

BET inhibitors block the Epstein-Barr virus lytic cycle at two distinct steps

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
human gammaherpesvirus 4; Homo sapiens
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other
Platforms:
GPL23362 GPL22131 GPL22132
106 Samples
Download data: WIG
Series
Accession:
GSE84214
ID:
200084214
2.

BET inhibitors suppress BZLF1 expression [MutuI RNA-seq]

(Submitter supplied) Lytic infection by the Epstein-Barr virus (EBV) poses numerous health risks, such as infectious mononucleosis and lymphoproliferative disorder. We demonstrate that JQ1 and other BET inhibitors block two different steps in the sequential cascade of the EBV life cycle: expression of the immediate-early gene BZLF1 and lytic genome replication. This represents a novel mode of action for antiviral drugs that may increase efficacy and decrease emergence of resistance. more...
Organism:
Homo sapiens; human gammaherpesvirus 4
Type:
Expression profiling by high throughput sequencing
Platform:
GPL22131
12 Samples
Download data: WIG, XLSX
Series
Accession:
GSE84209
ID:
200084209
3.

Illumina HiSeq 2500 (Homo sapiens; Human herpesvirus 4)

Organism:
Homo sapiens; human gammaherpesvirus 4
4 Series
35 Samples
Download data
Platform
Accession:
GPL22131
ID:
100022131
4.

RNA-seq_MutuI+Ab_Replicate3

Organism:
Homo sapiens; human gammaherpesvirus 4
Source name:
MutuI (EBV+ Burkitt lymphoma cell line)
Platform:
GPL22131
Series:
GSE84209 GSE84214
Download data: WIG
Sample
Accession:
GSM2229416
ID:
302229416
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Supplemental Content

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