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Items: 4

1.

The Gcn4 Transcription Factor Reduces Protein Synthesis Capacity and Extends Yeast Lifespan

(Submitter supplied) In Saccharomyces cerevisiae, deletion of genes encoding proteins of the large ribosomal subunit (RPLs) increases the replicative lifespan in a Gcn4-dependent manner. However, how Gcn4, a key transcriptional activator of amino acid biosynthesis genes, increases lifespan, is unknown. Here we show that Gcn4 acts as a repressor of protein synthesis. By analyzing the mRNA and protein abundance, the ribosome occupancy and protein synthesis rate in various yeast strains, we demonstrate that Gcn4 is sufficient to reduce protein synthesis and to increase yeast lifespan. more...
Organism:
Saccharomyces cerevisiae
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing; Other
Platforms:
GPL17342 GPL19756
52 Samples
Download data
Series
Accession:
GSE85591
ID:
200085591
2.

The Gcn4 Transcription Factor Reduces Protein Synthesis Capacity and Extends Yeast Lifespan [RNA-Seq]

(Submitter supplied) In Saccharomyces cerevisiae, deletion of genes encoding proteins of the large ribosomal subunit (RPLs) increases the replicative lifespan in a Gcn4-dependent manner. However, how Gcn4, a key transcriptional activator of amino acid biosynthesis genes, increases lifespan, is unknown. Here we show that Gcn4 acts as a repressor of protein synthesis. By analyzing the mRNA and protein abundance, the ribosome occupancy and protein synthesis rate in various yeast strains, we demonstrate that Gcn4 is sufficient to reduce protein synthesis and to increase yeast lifespan. more...
Organism:
Saccharomyces cerevisiae
Type:
Expression profiling by high throughput sequencing; Other
Platforms:
GPL19756 GPL17342
50 Samples
Download data: CSV, TXT
Series
Accession:
GSE85590
ID:
200085590
3.

Illumina NextSeq 500 (Saccharomyces cerevisiae)

Organism:
Saccharomyces cerevisiae
422 Series
11940 Samples
Download data
Platform
Accession:
GPL19756
ID:
100019756
4.

Riboseq_drpl6a_rep1

Organism:
Saccharomyces cerevisiae
Source name:
drpl6a
Platform:
GPL19756
Series:
GSE85590 GSE85591
Download data
Sample
Accession:
GSM2278868
ID:
302278868
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